A5045465452- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Thyroid Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Radiation Dose and Imaging
- Medical Imaging and Pathology Studies
- Advanced MRI Techniques and Applications
- Bone Tumor Diagnosis and Treatments
- Adrenal and Paraganglionic Tumors
- Bone health and treatments
- Pituitary Gland Disorders and Treatments
- Hematological disorders and diagnostics
- Parathyroid Disorders and Treatments
- Osteomyelitis and Bone Disorders Research
- Orthopedic Infections and Treatments
- Radiopharmaceutical Chemistry and Applications
- Thyroid and Parathyroid Surgery
- Advanced X-ray and CT Imaging
- Oral and Maxillofacial Pathology
- Infectious Diseases and Tuberculosis
- Cardiac Imaging and Diagnostics
Radboud University Nijmegen
2009-2025
Radboud University Medical Center
2009-2025
Leiden University Medical Center
2016-2024
Leiden University
2016-2021
GTx (United States)
2013
Copenhagen University Hospital
2012
Rigshospitalet
2012
Abstract Purpose We conducted a cost-effectiveness analysis in which we compared preoperative [ 18 F]Fluorocholine PET/CT-based one-stop-shop imaging strategy with current best practice PET/CT is only recommended after negative or inconclusive 99m Tc]Tc-methoxy isobutyl isonitrile SPECT/CT for patients suffering from primary hyperparathyroidism. investigated whether the performs as well but at lower costs. Methods developed cohort-level state transition model to evaluate both strategies...
Accurate measurement of intratumor heterogeneity using parameters texture on PET images is essential for precise characterization cancer lesions. In this study, we investigated the influence respiratory motion and varying noise levels quantification textural in patients with lung cancer. <b>Methods:</b> We used an optimal-respiratory-gating algorithm list-mode data 60 who underwent <sup>18</sup>F-FDG PET. The were reconstructed a duty cycle 35% (percentage total acquired data). addition,...
Abstract Purpose To assess the impact of an [ 18 F]FDG-PET/CT-driven diagnostic workup to rule out malignancy, avoid futile surgeries, and improve patient outcomes in thyroid nodules with indeterminate cytology. Methods In this double-blinded, randomised controlled multicentre trial, 132 adult euthyroid patients scheduled surgery for a Bethesda III or IV nodule underwent F]FDG-PET/CT were group. group, management was based on result: when index visually F]FDG-positive, advised;...
For the quantification of dynamic (18)F-FDG PET studies, arterial plasma time-activity concentration curve (APTAC) needs to be available. This can obtained using serial sampling blood or an image-derived input function (IDIF). Arterial is invasive and often not feasible in practice; IDIFs are biased because partial-volume effects cannot used when no large pool field view. We propose a mathematic function, consisting initial linear rising activity followed by triexponential decay, describe...
Patients with thyroid nodules of indeterminate cytology undergo diagnostic surgery according to current guidelines. In 75% patients, the nodule is benign. these was unnecessary and unbeneficial because complications may occur. Preoperative fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) found have a very high negative predictive value (96%) might therefore avoid futile surgery, complications, costs. United States, two molecular tests material are routinely...
Abstract Purpose To evaluate whether quantitative [ 18 F]FDG-PET/CT assessment, including radiomic analysis of F]FDG-positive thyroid nodules, improved the preoperative differentiation indeterminate nodules non-Hürthle cell and Hürthle cytology. Methods Prospectively included patients with a Bethesda III or IV nodule underwent imaging. Receiver operating characteristic (ROC) curve was performed for standardised uptake values (SUV) SUV-ratios, assessment SUV cut-offs at which...
In this PD-L1 ImagiNg to prediCt durvalumab treatment response in SCCHN (PINCH) study, we performed <sup>89</sup>Zr-DFO-durvalumab (anti–PD-L1 [programmed death ligand 1]) PET/CT patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) before monotherapy treatment. The primary aims were assess safety feasibility PET imaging predict disease control rate during Secondary correlate uptake tumor expression, <sup>18</sup>F-FDG uptake, individual lesions....
Chronic nonbacterial osteitis (CNO) is a rare disease spectrum, which lacks biomarkers for activity. Sodium fluoride-18 positron emission tomography/computed tomography ([
In this observational cohort study, we examined the prognostic value of growth and differentiation factor 15 (GDF15) in indicating monitoring general mitochondrial disease severity progression adult carriers m.3243A>G mutation.Ninety-seven mutation were included study. The Newcastle scale was used for rating severity. parallel, blood drawn GDF15 analysis by ELISA. Forty-nine a follow-up small subset subjects whom an echocardiogram available from patient care, myocardial deformation assessed...
Abstract Osteitis of the sternocostoclavicular (SCC) region, referred to as hyperostosis (SCCH), is clinical expression chronic non-bacterial osteitis (CNO) in adults with this rare auto-inflammatory disorder axial skeleton. The diagnosis based on distinctive computerized tomography (CT) features sclerosis and SCC local increases osteoid formation visualized by high radiopharmacon uptake skeletal scintigraphy but clear radiologic diagnostic criteria are lacking. In a cross-sectional study,...
In lung cancer patients with multiple lesions, the differentiation between metastases and second primary tumours has significant therapeutic prognostic implications. The aim of this retrospective study was to investigate potential (18)F-FDG PET discriminate metastatic disease from tumours.Of 1,396 evaluated by thoracic oncology group January 2004 April 2009 at Radboud University Nijmegen Medical Centre, a synchronous were selected. Patients involving lungs served as control group. Maximum...
<h3>Objectives:</h3> To determine the value of fibroblast growth factor 21 (FGF21), a recently discovered biomarker for mitochondrial disease, in predicting clinical disease severity and progression adult carriers m.3243A>G mutation. <h3>Methods:</h3> In context national inventory, heteroplasmy levels mutation were measured leukocytes urinary epithelial cells. The Newcastle Mitochondrial Disease Adult Scale score was determined blood drawn measuring FGF21 concentration. Twenty-five...
<sup>18</sup>F-FDG PET is well established in the field of oncology for diagnosis and staging purposes increasingly being used to assess therapeutic response prognosis. Many quantitative indices can be characterize tumors on images, such as SUV<sub>max</sub>, metabolically active tumor volume (MATV), total lesion glycolysis, and, more recently, proposed intratumor uptake heterogeneity features. Although most data considered within this context concern analysis activity distribution using...
Based on germline and somatic mutation profiles, pheochromocytomas paragangliomas (PPGLs) can be classified into different clusters. We investigated the use of [18F]FDG-PET/CT radiomics, SUVmax biochemical profile for identification genetic clusters PPGLs.In this single-centre cohort, 40 PPGLs (13 cluster 1, 18 2, 9 sporadic) were delineated using a 41% adaptive threshold SUVpeak ([18F]FDG-PET) manually (low-dose CT; ldCT). Using PyRadiomics, 211 radiomic features extracted. Stratified...
Static single–time-frame <sup>18</sup>F-FDG PET/CT is useful for the localization and functional characterization of pheochromocytomas paragangliomas (PPGLs). uptake varies between PPGLs with different genotypes, highest SUVs are observed in cases succinate dehydrogenase (<i>SDH</i>) mutations, possibly related to enhanced aerobic glycolysis tumor cells. The exact determinants accumulation unknown. We performed dynamic scanning assess whether vivo pharmacokinetics has added value over static...
<sup>123</sup>I-metaiodobenzylguanidine (<sup>123</sup>I-MIBG) scintigraphy plays an important role in the diagnostic evaluation of patients with pheochromocytoma and paraganglioma (PPGL). <sup>123</sup>I-MIBG targets cell membrane vesicular catecholamine transporters chromaffin cells facilitates localization primary tumor metastatic lesions. Its specificity for diagnosis adrenomedullary tumors can be jeopardized by physiologic uptake normal adrenal medulla. The aim this study was to...
Abstract Purpose To evaluate cost-effectiveness of an [ 18 F]FDG-PET/CT-driven diagnostic workup as compared to surgery, for thyroid nodules with Bethesda III/IV cytology. F]FDG-PET/CT avoids 40% futile surgeries benign nodules. Methods Lifelong societal costs and quality-adjusted life years (QALYs) were assessed 132 patients participating in a randomised controlled multicentre trial comparing surgery. The observed 1-year results extrapolated using Markov model. probability was estimated...