A5088569850- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Occupational and environmental lung diseases
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Mechanical Circulatory Support Devices
- Surgical site infection prevention
- Surgical Simulation and Training
- Advanced Radiotherapy Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Myasthenia Gravis and Thymoma
- Lung Cancer Treatments and Mutations
- Orthopedic Infections and Treatments
- Immunotherapy and Immune Responses
- Trauma Management and Diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Transplantation: Methods and Outcomes
- Cancer Research and Treatments
- Medical Imaging and Pathology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Airway Management and Intubation Techniques
Erasmus University Rotterdam
2014-2024
Erasmus MC
2012-2024
ERN GUARD-Heart
2024
Erasmus MC Cancer Institute
2012-2022
European Organisation for Research and Treatment of Cancer
2009
Antwerp University Hospital
2009
European Organisation for Research and Treatment of Cancer
2009
The Netherlands Cancer Institute
2009
Instituut Verbeeten
2009
Rotterdam University of Applied Sciences
1994-2004
Abstract Objective: To test the hypothesis that perioperative elimination of nasal carriage Staphylococcus aureus using mupirocin ointment reduces surgical-site infection (SSI) rate in cardiothoracic surgery. Design: Unblinded intervention trial with historical controls. Setting: A university hospital, tertiary referral center for Patients: Consecutive patients undergoing surgery between August 1, 1989, and February 1991 (historical control group), March 1991, 1992 (intervention group)....
The European Organisation for Research and Treatment of Cancer (EORTC; protocol 08031) phase II trial investigated the feasibility trimodality therapy consisting induction chemotherapy followed by extrapleural pneumonectomy post-operative radiotherapy in patients with malignant pleural mesothelioma (with a severity cT3N1M0 or less). Induction consisted three courses cisplatin 75 mg·m −2 pemetrexed 500 . Nonprogressing underwent (54 Gy, 30 fractions). Our primary end-point was “success...
Rationale: We demonstrated previously that autologous tumor lysate–pulsed dendritic cell–based immunotherapy in patients with malignant pleural mesothelioma is feasible, well-tolerated, and capable of inducing immunologic responses against cells. In our murine model, we found reduction regulatory T cells metronomic cyclophosphamide increased the efficacy immunotherapy.Objectives: To assess decrease number peripheral blood during combination therapy low-dose cell determine induction this...
There has been an increasing trend toward pulmonary segmentectomies to treat early-stage lung cancer, small intrapulmonary metastases, and localized benign pathology. A complete preoperative understanding of anatomy is essential for accurate surgical planning case selection. Identifying intersegmental divisions extremely difficult when performed on computed tomography. For the segmentectomies, virtual reality (VR) artificial intelligence could allow 3-dimensional visualization complex...
The role of surgery in pleural mesothelioma remains controversial. It may be appropriate highly selected patients as part a multimodality treatment including chemotherapy. Recent years have seen shift from extrapleural pleuropneumonectomy toward extended pleurectomy/decortication. most optimal sequence and chemotherapy unknown.
Extensive left ventricular (LV) remodeling may not allow functional recovery after revascularization, despite the presence of viable myocardium.Seventy-nine consecutive patients with ischemic cardiomyopathy (left ventricle ejection fraction [LVEF] 29+/-7%) underwent surgical revascularization. Before viability was assessed by metabolic imaging F18-fluorodeoxyglucose and SPECT. LV volumes LVEF were resting echocardiography. re-assessed echocardiography 8 to 12 months Three-year clinical...
The tumor micro-environment and especially the different macrophage phenotypes appear to be of great influence on behavior multiple types. M1 skewed macrophages possess anti-tumoral capacities, while M2 polarized have pro-tumoral capacities. We analyzed if count total ratio is a discriminative marker for outcome after surgery in malignant pleural mesothelioma (MPM) studied prognostic value these immunological cells.8 MPM patients who received induction chemotherapy surgical treatment were...
Malignant mesothelioma (MM) is an aggressive cancer that primarily arises from the pleura (MPM) or peritoneum (MPeM), mostly due to asbestos exposure. This study reviewed Dutch population-based incidence, treatment and survival since national ban on in 1993.Patients with MPM MPeM diagnosed 1993 2018 were selected registry. Annual percentage change (APC) was calculated for (age-specific sex-specific) revised European standardised incidence rates (RESR). Treatment pattern Kaplan-Meier overall...
Characterization of the biochemical composition normal bronchial tissue is a prerequisite for understanding changes that accompany histological during lung cancer development. In this study, 12 Raman microspectroscopic mapping experiments are performed on frozen sections tissue. Pseudocolor images constructed using principal component analysis and K-means cluster analysis. Subsequent comparison with histologic evaluation stained enables identification morphologic origin (e.g., mucus,...
Abstract Aims Many heart transplant recipients will develop end‐stage renal disease in the post‐operative course. The aim of this study was to identify long‐term incidence disease, determine its risk factors, and investigate what subsequent therapy associated with best survival. Methods results A retrospective, single‐centre performed all adult patients from 1984 2016. Risk factors for were analysed by means multivariable regression analysis survival Kaplan–Meier. Of 685 recipients, 71...
Increased complexity in cardiac surgery over the last decades necessitates more precise preoperative planning to minimize operating time, limit risk of complications during and aim for best possible patient outcome. Novel, realistic, immersive techniques, such as three-dimensional (3D) virtual reality (VR) could potentially contribute phase. This study shows our initial experience on implementation VR technology a complementary research-based imaging tool cardiothoracic surgery. In addition,...
iSR: interactive simulated reality Central Picture LegendReal-time AI-assisted augmented view during robotic-assisted thoracic surgery messageTechnological feasibility of an artificial intelligence (AI)-based approach to enable (registration/dynamic tracking) robotic lung with deformable and 3D-models.
Background— In patients with ischemic cardiomyopathy, left ventricular (LV) remodeling is an important prognostic indicator. The precise relation between viable myocardium, revascularization, and ongoing or reversed unknown was evaluated in the present study. Methods Results— A total of 100 cardiomyopathy underwent dobutamine stress echocardiography to assess myocardial viability LV geometry (volumes shape). At a mean 10.2 months 4.5 years after resting repeated evaluate remodeling....
The nationwide Dutch Lung Surgery Audit (DLSA) started in 2012 to monitor and evaluate the quality of lung operations Netherlands as an improvement tool. This outline describes establishment, structure, organization audit by Society Surgeons (NVvL) Cardiothoracic (NVT), collaboration with Institute for Clinical Auditing. In addition, first 4-year results are presented.The NVvL NVT initiated a web-based registration, including weekly updated online feedback participating hospitals. Data...
The objective of this study is to investigate the role and experience early stage non-small cell lung cancer (NSCLC) patient in decision making process concerning treatment selection current clinical practice. Stage I-II NSCLC patients (surgery 55 patients, SBRT 29 median age 68) were included prospective completed a questionnaire that explored: (1) perceived knowledge advantages disadvantages options, (2) with making, (3) information reported have received from their treating physician....
Background— Patients with ischemic cardiomyopathy and viable myocardium may improve in function prognosis following revascularization. Delayed revascularization result less favorable outcome, therefore the impact of timing on long-term outcome was evaluated. Methods Results— (n=85) substantial viability (≥25% left ventricle) dobutamine stress echocardiography underwent surgical Based waiting time for revascularization, patients were divided into 2 groups: early (≤1 month) late (>1 Left...
To assess the cost-effectiveness of perioperative intranasal application mupirocin calcium ointment in cardiothoracic surgery.Cost-effectiveness analysis based on results an intervention study with historical controls.University Hospital Rotterdam, a tertiary referral center for cardiac and pulmonary surgery.Consecutive patients undergoing surgery between August 1, 1989, February 1991 (control group, n = 928), March 1991, 1992 (intervention 868).Perioperative nasal started day before...