A5000835217- Peatlands and Wetlands Ecology
- Mesenchymal stem cell research
- Hydrology and Watershed Management Studies
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Hydrology and Sediment Transport Processes
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Soil erosion and sediment transport
- TGF-β signaling in diseases
- Protein Degradation and Inhibitors
- Tissue Engineering and Regenerative Medicine
- Forest Ecology and Biodiversity Studies
- Cancer Genomics and Diagnostics
- Bone health and treatments
- Lymphoma Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Environmental Conservation and Management
- Blood Coagulation and Thrombosis Mechanisms
- Histone Deacetylase Inhibitors Research
- Cancer Cells and Metastasis
- Platelet Disorders and Treatments
- Immune Cell Function and Interaction
Universitair Ziekenhuis Brussel
2016-2025
Vrije Universiteit Brussel
2011-2024
Takeda (United States)
2023
KU Leuven
2022
Cliniques Universitaires Saint-Luc
2022
Université Claude Bernard Lyon 1
2022
Palmetto Hematology Oncology
2003-2019
Research Institute for Nature and Forest
1999-2013
Agentschap voor Natuur en Bos
2013
Cincinnati Children's Hospital Medical Center
1996-2011
PURPOSE: To identify clinical and laboratory parameters present at the time of a first evaluation that could help predict which children with cancer, fever, neutropenia were high risk or low for an invasive bacterial infection. PATIENTS AND METHODS: Over 17-month period, all admitted to five hospitals in Santiago, Chile, enrolled onto prospective protocol. Associations between admission infection assessed by univariate logistic regression analyses. RESULTS: A total 447 febrile neutropenic...
Background and Objectives Mesenchymal stem cells (MSC) are adult that can be expanded many fold in vitro have the therapeutic potential to restore bone marrow microenvironment support hematopoietic recovery after myeloablative conditioning for cell transplantation. Successful homing target tissue, such as marrow, implies MSC able extravasate systemic administration. However, extravasation capacity of underlying mechanisms poorly understood date. We studied migrate through endothelium.Design...
Circulating stem cells home within the myocardium, probably as first step of a tissue regeneration process. This requires adhesion to cardiac microvascular endothelium (CMVE). In this study, we studied mechanisms between CMVE and mesenchymal (MSCs). Adhesion was in vitro vivo. Isolated 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate-labeled rat MSCs were allowed adhere cultured static dynamic conditions. Either or pretreated with cytokines [IL-1β, IL-3, IL-6, cell factor,...
Neutropenia may limit the use of valganciclovir treatment for cytomegalovirus (CMV) infection following hematopoietic cell transplant (HCT). A phase 2 study indicated efficacy maribavir with fewer treatment-limiting toxicities than valganciclovir.
Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells that are predominantly localized in the bone marrow (BM). Mesenchymal stromal (MSCs) give rise to most BM interact with MM cells. However, direct involvement MSCs pathophysiology has not been well addressed. In this study, vitro and vivo migration assays revealed have tropism toward cells, CCL25 was identified as major cell-produced chemoattractant for MSCs. By coculture experiments, we found favor proliferation...
Previous studies have demonstrated that mesenchymal stem cells from multiple myeloma (MM) patients (MM-hMSCs) display a distinctive gene expression profile, an enhanced production of cytokines and impaired osteogenic differentiation ability compared to normal donors (ND-hMSCs). However, the underlying molecular mechanisms are unclear. In present study, we observed MM-hMSCs exhibited abnormal upregulation miR-135b, showing meanwhile decrease SMAD5 expression, which is target miR-135b involved...
Studies in adults have demonstrated that the genetic mutations C677T methylenetetrahydrofolate reductase (MTHFR), prothrombin 20210A, and 4G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene are associated with elevated plasma levels homocysteine. PAI-1, respectively an increased risk thrombosis. No similar data is available children. Therefore, we assessed relationship homocysteine, PAI-1 their respective 197 normal children, compared to 40 adults. By stepwise multiple...
Abstract Background The capability of human mesenchymal stem cells (hMSC) derived adult bone marrow to undergo in vitro hepatic differentiation was investigated. Results Exposure hMSC a cocktail hepatogenic factors [(fibroblast growth factor-4 (FGF-4), hepatocyte factor (HGF), insulin-transferrin-sodium-selenite (ITS) and dexamethasone)] failed induce differentiation. Sequential exposure these (FGF-4, followed by HGF, HGF+ITS+dexamethasone), however, resembling the order secretion during...
Mycoplasma genitalium (MG) is an emerging pathogen among men who have sex with (MSM) raising rates of antibiotic resistance. This study assessed the prevalence and incidence MG infection in MSM enrolled open-label phase ANRS IPERGAY trial on-demand tenofovir disoproxil fumarate/emtricitabine for human immunodeficiency virus prevention impact doxycycline post-exposure prophylaxis (PEP).210 subjects were tested at baseline 6 months by real-time PCR assays detection urine samples oropharyngeal...
Introduction Poor graft function (PGF) is a rare but serious complication of allogeneic hematopoietic cell transplantation (alloHCT). Due to their supporting properties and immune regulatory effects, multipotent mesenchymal stromal cells (MSC) could be considered good candidate help restore bone marrow (BM) niches homeostasis facilitate hematopoiesis after alloHCT. Methods We prospectively assessed the efficacy safety ex-vivo expanded BM-derived MSC from third-party donor in series 30...
AXL expression has been identified as a prognostic factor in acute myeloid leukemia (AML) and is detectable approximately 50% of AML patients. In this study, we developed AXL-specific single domain antibodies (sdAbs), cross-reactive for both mouse human protein, to non-invasively image treat AXL-expressing cancer cells.
Thrombophilia may cause thrombotic venous occlusion in the femoral head, with hypertension and hypoxic bone death, leading to Legg-Perthes disease. Resistance activated protein C, most common thrombophilic trait, was measured 64 children Genomic deoxyribonucleic acid studied delineate CGA-->CAA substitution at position 1691 of Factor V Leiden gene responsible for resistance C. The C ratio calculated by dividing clotting time obtained C-calcium chloride calcium alone. a low (less than 2.19,...
The production of inhibin in cultured granulosa cells from immature hypophysectomized, estrogen-treated rats and Sertoli normal animals was determined by a specific radioimmunoassay using an antiserum against synthetic replicate [Tyr30]inhibin alpha-chain-(1-30). amount immunoreactive detected the spent media these is proportion to density plated concentration exogenously added follicle-stimulating hormone (FSH). In presence estrogen precursor androstenedione (10(-7) M), FSH, but not...
Compared to bone marrow (BM) derived mesenchymal stem cells (MSCs) from human origin or other species, the in vitro expansion and purification of murine MSCs (mMSCs) is much more difficult because low MSC yield unwanted growth non-MSCs cultures. We describe a modified protocol isolate expand BM based on combination mechanical crushing collagenase digestion at moment harvest, followed by an immunodepletion step using microbeads coated with CD11b, CD45 CD34 antibodies. The number isolated...
Few studies thus far have compared head-to-head different non-myelooablative conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT). Here, we report the results of a phase II multicenter randomized study comparing non-myeloablative allo-HCT from HLA-identical siblings (n = 54) or 10/10 HLA-matched unrelated donors 40) with either fludarabine plus 2 Gy total body irradiation (Flu-TBI arm; n 49) 8 TLI + anti-thymocyte globulin (TLI-ATG 45) conditioning. The 180-day...