A5061685477- Neutropenia and Cancer Infections
- Bacterial Identification and Susceptibility Testing
- Blood disorders and treatments
- Hematological disorders and diagnostics
- Antifungal resistance and susceptibility
- Herpesvirus Infections and Treatments
- Streptococcal Infections and Treatments
- Polyomavirus and related diseases
- Fungal Infections and Studies
- Mycobacterium research and diagnosis
- Chemotherapy-related skin toxicity
- Chronic Lymphocytic Leukemia Research
- Antibiotic Resistance in Bacteria
- Plant Virus Research Studies
- Oral health in cancer treatment
- Cancer Treatment and Pharmacology
- Tuberculosis Research and Epidemiology
- Otolaryngology and Infectious Diseases
- Toxoplasma gondii Research Studies
- Infectious Diseases and Mycology
- Genetic and rare skin diseases.
- Cytomegalovirus and herpesvirus research
- Histiocytic Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Parvovirus B19 Infection Studies
Université Libre de Bruxelles
2005-2025
Institut Jules Bordet
2012-2025
Centre Hospitalier Universitaire Brugmann
2010-2011
Hospital Universitário de Santa Maria
2007
University Hospital of Lausanne
2007
Neutropenia may limit the use of valganciclovir treatment for cytomegalovirus (CMV) infection following hematopoietic cell transplant (HCT). A phase 2 study indicated efficacy maribavir with fewer treatment-limiting toxicities than valganciclovir.
Among the challenges in controlling tuberculosis, a rapid and accurate diagnostic test for detection of Mycobacterium tuberculosis complex (MTBc) its resistance to first line therapies is crucial. We evaluated performance Xpert MTB/RIF Ultra assay (Xpert Ultra) MTBc rifampicin (RR) 1120 pulmonary 461 extra-pulmonary clinical specimens compared it with conventional phenotypic techniques. The detected 223 (14.1%) samples an overall sensitivity specificity, using culture as "gold standard",...
Background. Infections caused by acyclovir-resistant isolates of herpes simplex virus (HSV) after hematopoietic stem cell transplantation (HSCT) are an emerging concern. An understanding the evolutionary aspects HSV infection is crucial to design effective therapeutic and control strategies. Methods. Eight sequential HSV-1 were recovered from HSCT patient who suffered recurrent herpetic gingivostomatitis was treated alternatively with acyclovir, ganciclovir, foscavir. The diverse spectra...
: Case presentation: We present the case of a 37-year-old female patient who developed an acute respiratory failure requiring mechanical ventilation, two months after term delivery by cesarian section. The diagnosis gestational trophoblastic neoplasia was suspected due to high level HCG in post-partum period and thoracic imaging suggesting multiple pulmonary metastases. No biopsy available. She subsequently severe ARDS veno-venous extracorporeal membrane oxygenation (VV-ECMO) support...
Hemorrhagic cystitis that occurs late after bone marrow transplantation (BMT) in BMT recipients is often associated with adenovirus or polyomavirus BK infections. Intravesical instillation of cidofovir a recipient intractable hemorrhagic resulted clinical improvement. Local therapy for viral could be an alternative to intravenous administration cidofovir.
Background. Mannose-binding lectin (MBL) is a serum involved in innate immune response. Low MBL concentration may constitute risk factor for infection patients receiving myelosuppressive chemotherapy. Methods. We conducted prospective, observational study that assessed as with hematological malignancy who were hospitalized to undergo at least 1 chemotherapy cycle. deficiency was defined using an algorithm considered the and genotype. The primary end point ratio of duration febrile...
Abstract Background Herpes simplex virus 1 can cause severe infections in individuals who are immunocompromised. In these patients, emergence of drug resistance mutations causes difficulties infection management. Methods Seventeen herpes isolates were obtained from orofacial/anogenital lesions a patient with leaky combined immunodeficiency over 7 years, before and after stem cell transplantation. Spatial/temporal evolution was characterized genotypically—with Sanger next-generation...
Abstract Non-Hodgkin's lymphoma (NHL) may be preceded by chronic inflammatory diseases and furthermore has been related to immune deficiency. Tuberculosis (TB), on the other hand, is a infectious disease whose presentation reactivation known promoted cell mediated immunodeficiency. The coexistence of NHL TB in same organ rare. We report two cases different organs: cervical lymph nodes kidney. illustrate how misleading concurrence infection can be, delaying diagnosis treatment either disease.
Clinical research in febrile neutropenia cancer patients: Past achievements and perspectives for the future
Tyrosine kinase inhibitors (TKIs) and immune checkpoint (ICIs) significantly improve the outcomes of patients with advanced clear cell renal carcinoma (ccRCC); however, high-grade toxicities can occur, particularly during combination therapy. Herein, we report a patient metastatic ccRCC, who developed grade 4 cholestasis combined therapy nivolumab cabozantinib. After exclusion common disorders associated failure corticosteroids (CS), liver biopsy was performed that demonstrated severe...
A 61-year-old female, followed-up for a metastatic breast cancer, was admitted in our institution with conjunctival icterus, asthenia and abdominal crampoid pain. The patient included clinical trial comparing the efficiency of capecitabine monotherapy versus conjugated new biological agent randomised double blind trial. alone arm. Biological tests performed upon admission suggested diagnosis haemolytic anaemia. Moreover, direct Coombs test result twice positive indicating autoimmune...