A5064489513- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Poxvirus research and outbreaks
- Food Allergy and Anaphylaxis Research
- vaccines and immunoinformatics approaches
- Animal Virus Infections Studies
- Ubiquitin and proteasome pathways
- Immunotherapy and Immune Responses
- Plant Virus Research Studies
- Research on Leishmaniasis Studies
- Systemic Lupus Erythematosus Research
KU Leuven
2022-2024
Rega Institute for Medical Research
2022-2024
Utrecht University
2017
Abstract Background Herpes simplex virus 1 can cause severe infections in individuals who are immunocompromised. In these patients, emergence of drug resistance mutations causes difficulties infection management. Methods Seventeen herpes isolates were obtained from orofacial/anogenital lesions a patient with leaky combined immunodeficiency over 7 years, before and after stem cell transplantation. Spatial/temporal evolution was characterized genotypically—with Sanger next-generation...
Ocular herpes simplex virus 1 (HSV-1) infections can lead to visual impairment. Long-term acyclovir (ACV) prophylaxis reduces the frequency of recurrences but is associated with drug resistance. Novel therapies are needed treat drug-resistant HSV-1 infections. Here, we describe effects trifluridine (TFT) in combination ACV or ganciclovir (GCV) on replication and drug-resistance emergence. Wild-type was grown under increasing doses one antiviral (ACV, GCV, TFT) combinations thereof (ACV + TFT...
Abstract Background Prolonged antiviral therapy in immunocompromised individuals can result the emergence of (multi)drug-resistant herpes simplex virus 1 (HSV-1) infections, forming a therapeutic challenge. Objectives To evaluate spatial and temporal differences drug resistance HSV-1 samples from HSCT recipient to determine effect mutations on viral replication fitness. Patients methods Five isolates were recovered who suffered persistent lesions, consecutively treated with aciclovir,...
The widespread use of antivirals in immunocompromised individuals has led to frequent occurrences drug-resistant herpes simplex virus 1 (HSV-1) infections. Current target the viral DNA polymerase (DP), resulting cross-resistance patterns that emphasize need for novel treatment strategies. In this study, we assessed whether combining with different targets affects drug resistance emergence by passaging wild-type HSV-1 under increasing concentrations acyclovir (ACV), foscarnet (phosphonoformic...