A5076256489- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Nuclear Structure and Function
- Microscopic Colitis
- CAR-T cell therapy research
- Virus-based gene therapy research
- Cervical Cancer and HPV Research
- vaccines and immunoinformatics approaches
- Viral Infections and Immunology Research
- Immunotherapy and Immune Responses
- Parasites and Host Interactions
- Inflammatory Bowel Disease
- Ubiquitin and proteasome pathways
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Animal Disease Management and Epidemiology
- Gut microbiota and health
Karolinska Institutet
2018-2023
Karolinska University Hospital
2020-2021
Oncode Institute
2020
The Netherlands Cancer Institute
2020
Utrecht University
2017
Boston College
2013-2015
An increasing body of evidence emphasizes the role tissue-resident memory T cells (TRM) in defense against recurring pathogens and malignant neoplasms. However, little is known with regard to origin these their kinship other CD8+ cell compartments. To address this issue, we followed antigen-specific progeny individual naive effector (TEFF), circulating (TCIRCM), TRM pools by lineage-tracing single-cell transcriptome analysis. We demonstrate that a subset clones possesses heightened capacity...
The gastrointestinal microenvironment, dominated by dietary compounds and the commensal bacteria, is a major driver of intestinal CD4+ T helper (Th) cell differentiation. Dietary can be sensed nuclear receptors (NRs) that consequently exert pleiotropic effects including immune modulation. Here, we found under homeostatic conditions NR Liver X receptor (LXR), sensor cholesterol metabolites, regulates RORγt+ CD4 cells in intestine draining mesenteric lymph node (MLN). While LXR activation led...
Intestinal helminth parasites can alter immune responses to vaccines, other infections, allergens and autoantigens, implying effects on host in distal barrier tissues. We herein show that the skin of C57BL/6 mice infected with strictly intestinal nematode Heligmosomoides polygyrus contain higher numbers CD4+ T cells compared uninfected controls. Accumulated were H. polygyrus-specific TH2 skewed cell composition towards a TH2/TH1 ratio which persisted after worm expulsion. Accumulation was...
Commensal-specific clusters of differentiation (CD)4