A5087144458- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Plant Parasitism and Resistance
- Plant and animal studies
- Catalytic Cross-Coupling Reactions
- Catalytic C–H Functionalization Methods
- Coordination Chemistry and Organometallics
- Chemical Synthesis and Reactions
- Catalytic Alkyne Reactions
- Asymmetric Hydrogenation and Catalysis
- Plant Molecular Biology Research
- Oxidative Organic Chemistry Reactions
- Advanced Synthetic Organic Chemistry
- Chemical synthesis and alkaloids
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Allelopathy and phytotoxic interactions
- Inorganic and Organometallic Chemistry
- Chemical Synthesis and Analysis
- Cyclopropane Reaction Mechanisms
- Chemical Reaction Mechanisms
- Legume Nitrogen Fixing Symbiosis
- Axial and Atropisomeric Chirality Synthesis
- Fluorine in Organic Chemistry
- Synthesis and Catalytic Reactions
University of Turin
2015-2024
Torino e-district
2015-2020
Weatherford College
2020
Centro Nacional de Biotecnología
2018
Universidad Autónoma de Madrid
2018
University of Florence
2010-2015
Agricultural Research Organization
2015
University College Dublin
2013
University of Bologna
2008
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2002-2005
Abstract In this work we report the synthesis of new fluorescent analogues strigolactones, their spectroscopic properties and evaluation biological activity both on seeds Orobanche aegyptiaca AM fungus Gigaspora margarita . The has been accomplished according to two different synthetic plans allows introduction various substituents A C rings framework, thus enabling access bioactive molecules with properties.
Directed ortho metalation (DoM) or nucleophilic acyl substitution (SNAc) can be efficiently programmed on the same aromatic carboxylic acid amide, in a choline chloride-based eutectic mixture, by simply switching nature of organolithium reagent. Telescoped, one-pot ortho-lithiation/Suzuki-Miyaura cross-couplings have also been demonstrated for first time Deep Eutectic Solvents.
A new class of strigolactone analogues has been synthesized. They differ from known molecules, both natural and synthetic origin, in two main features. The conjugated system extends the enol ether bridge to ring, B ring is a heterocycle while C cyclic ketone instead γ-lactone. key step synthesis Nazarov cyclization on activated substrates. Bioassays using Orobanche seeds have revealed that all molecules strongly stimulate germination; particular oxygen containing are most active....
Strigolactones are a novel class of plant hormones produced in roots and regulate shoot root development. We have previously shown that synthetic strigolactone analogues potently inhibit growth breast cancer cells stem cells. Here we show the survival an array cancer-derived cell lines representing solid non-solid including: prostate, colon, lung, melanoma, osteosarcoma leukemic lines, while normal were minimally affected. Treatment with was hallmarked by activation stress-related MAPKs: p38...
Strigolactones are a class of natural and synthetic compounds that in the past decade have been exciting scientific community not only for their intriguing biological properties but also potential applications agriculture. These range from use as hormones to modify and/or manage plant architecture, stimulants induce seed germination parasitic weeds thus control infestation by reduced bank, 'biostimulants' root colonisation arbuscular mycorrhizal fungi, improving nutritional capabilities,...
The Nazarov cyclization was successfully performed in acidic NaDESs with full recyclability and scalability.
Strigolactones (SLs) are plant hormones that regulate the response to phosphate (Pi) growth conditions. At least part of SL-signalling execution in roots involves MAX2-dependent effects on PIN2 polar localization plasma membrane (PM) and actin bundling dynamics. We examined expression, PM localization, endosome trafficking, under low-Pi conditions: a reduction trafficking polarization PM, reduced increased actin-filament were detected root cells. The intracellular protein is related PIN...
Strigolactones, a group of terpenoid lactones, control many aspects plant growth and development, but the active forms these hormones their mode action at molecular level are still unknown. The strigolactone protein receptor is unusual because it has been shown to cleave hormone supposedly covalent bond with cleaved fragment. This interaction suggested induce conformational change in that primes for subsequent partners signalling pathway. Substantial efforts have invested into describing...
// Monica Argenziano 1 , Chiara Lombardi 2 Benedetta Ferrara Francesco Trotta Fabrizio Caldera Marco Blangetti Hinanit Koltai 3 Yoram Kapulnik Ronit Yarden 4 Luca Gigliotti 5 Umberto Dianzani Cristina Prandi and Roberta Cavalli Department of Drug Science Technology, University Turin, Italy Chemistry, Agricultural Research Organization, Volcani Center, Rishon LeTsiyon, Israel Georgetown Medical Washington DC, USA Health Sciences, Universita del Piemonte Orientale, Novara, Correspondence to:...
Ultrafast heteroatom-directed lateral lithiation of substituted toluene derivatives using choline chloride-based eutectic mixtures as bio-inspired sustainable reaction media.
The Pd-catalyzed coupling reaction of lactam or lactone-derived vinyl triflates and phosphates with α-alkoxydienylboronates gives conjugated alkoxytrienes in which one the double bonds is embedded a heterocyclic moiety. If subjected to mild acidic hydrolysis, these compounds undergo 4π electrocyclization process (Nazarov reaction) furnishes cyclopenta-fused O- N-heterocycles good yields. scope work has been that closely examining role effect both heteroatom heterocycle ring size on outcome...
A new dual imaging and therapeutic agent is proposed to improve the efficacy of boron neutron capture therapy in cancer treatment.
Strigolactones (SLs) are a novel class of plant hormones. Previously, we found that analogs SLs induce growth arrest and apoptosis in breast cancer cell lines. These compounds also inhibited the stem enriched-mammospheres with increased potency. Furthermore, strigolactone survival colon, lung, prostate, melanoma, osteosarcoma leukemia To further examine anti-cancer activity vivo, have examined their effects on viability MDA-MB-231 tumor xenografts model either alone or combination...