A5020149540- Genomics, phytochemicals, and oxidative stress
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Hematopoietic Stem Cell Transplantation
- Pancreatic and Hepatic Oncology Research
- Multiple Myeloma Research and Treatments
- Synthesis and biological activity
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hemoglobinopathies and Related Disorders
- Cancer Genomics and Diagnostics
- Acute Myeloid Leukemia Research
- IL-33, ST2, and ILC Pathways
- Chronic Lymphocytic Leukemia Research
- Lower Extremity Biomechanics and Pathologies
- Musculoskeletal synovial abnormalities and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Management of metastatic bone disease
- Ovarian function and disorders
- Patient Safety and Medication Errors
- Clinical Reasoning and Diagnostic Skills
- Abdominal Surgery and Complications
- Healthcare Policy and Management
- Intraperitoneal and Appendiceal Malignancies
Allegheny Health Network
2019-2024
Lung Institute
2019-2022
King Hamad University Hospital
2020
University of Pittsburgh
2009-2018
UPMC Hillman Cancer Center
2015
University of Pittsburgh Medical Center
2013
University of Liège
2013
Aga Khan University
2006-2011
Aga Khan University Hospital
2008
The University of Texas MD Anderson Cancer Center
2008
Abstract Gastroesophageal cancer dynamics and drivers of clinical responses with immune checkpoint inhibitors (ICI) remain poorly understood. Potential synergistic activity dual programmed cell death protein 1 (PD-1) lymphocyte-activation gene 3 (LAG-3) inhibition may help improve immunotherapy for these tumors. We report a phase Ib trial that evaluated neoadjuvant nivolumab (Arm A, n = 16) or nivolumab–relatlimab B, in combination chemoradiotherapy 32 patients resectable stage II/stage III...
Approximately 20% of patients with multiple myeloma (MM) have renal failure at diagnosis, and about 5% are dialysis-dependent. Many these considered ineligible for autologous hematopoietic stem cell transplantation (auto-HSCT) because a high risk treatment-related toxicity. We evaluated the outcome 46 patient MM failure, defined as serum creatinine >2 mg/dL sustained >1 month before start preparative regimen. Patients received auto-HSCT our institution between September 1997 2006. Median...
142 Background: Neoadjuvant chemoradiation (cRT) prior to surgical resection in stage II/III esophageal/gastroesophageal junction (E/GEJ) cancer results a complete pathologic response rate (pCR) of 20-30%. The appearance favorable microenvironment features (enhanced tumor infiltrating lymphocytes, perivascular lymphocytes and tertiary lymphoid structures) after induction therapy resected EC suggest early tumors may respond favorably immune based particular PD-1 blockade when combined with...
Abstract A total of 149 patients with multiple myeloma (MM) who received allogeneic hematopoietic stem cell transplantation (allo‐HCT) myeloablative (MAC; n = 38) or reduced‐intensity conditioning (RIC; 110) regimens at MD Anderson Cancer Center were evaluated. Of the total, 120 (81%) had relapsed refractory disease. Median age MM was 50 (28–70) years a followup time 28.5 (3–164) months. The 100‐day and 5‐year treatment related mortality (TRM) rates 17% 47%, respectively. TRM significantly...
Isothiocyanates (ITCs) derived from cruciferous vegetables, including phenethyl isothiocyanate (PEITC) and sulforaphane (SFN), exhibit in vivo activity against prostate cancer a xenograft transgenic mouse model, thus are appealing for chemoprevention of this disease. Watercress constituent PEITC SFN-rich broccoli sprout extract under clinical investigations but the molecular mechanisms underlying their chemopreventive effects not fully understood. The present study demonstrates that...
Renal medullary carcinoma (RMC) is a rare but aggressive malignancy affecting young individuals with sickle cell trait. commonly presents advanced or metastatic disease and associated rapidly progressive clinical course an extremely short overall survival measured in weeks to few months. Due the rarity of RMC, there no proven effective therapy patients are often treated platinum-based chemotherapy. We report near-complete radiological pathological response patient dose-dense MVAC...
Relapsed acute myeloid leukemia (AML) represents a major therapeutic challenge. Achieving complete remission (CR) with salvage chemotherapy is the first goal of therapy for relapsed AML. However, there no standard chemotherapy. The current study evaluated outcomes and prognostic factors achievement CR in 91 AML patients relapse who were treated mitoxantrone‐etoposide combination regimen. overall response rate (CR CRi) was 25%. Factors that associated lower included older age, shorter...
321 Background: The phase III CheckMate 577 study resulted in adjuvant nivolumab becoming a new standard of care for patients with completely resected E/GEJ cancer residual pathologic disease post neoadjuvant chemoradiotherapy. We evaluated if (N) or nivolumab/relatlimab (N/R) combined chemoradiotherapy (CRT) can further improve patient outcomes. Methods: Patients stage II/III carcinoma eligible curative resection were treated regimen carboplatin (AUC2), paclitaxel (50mg/m2), RT 41.1Gy 23...
TNBC is associated with a high risk of local and distant recurrence diagnosed at relatively younger age. There paucity trials focusing on women ≥70 yrs TNBC. We aimed to determine the outcomes in relation age, residence, marital status independent known clinical variables. In this retrospective cohort study, early-stage operable invasive BC during 2010-2018 province Saskatchewan underwent curative surgery were included. A multivariate Cox proportional hazard model was performed. Various...
5618 Background: Chemotherapy is associated with many adverse side effects including nausea, myalgia, and emotional stress. Some providers recommend three days of dexamethasone (supplemental dexamethasone) following chemotherapy in an effort to mitigate these toxicities. This study seeks determine if supplemental affects patient-reported outcomes patients receiving carboplatin paclitaxel. Methods: Patients gynecologic malignancies paclitaxel every 3 weeks were eligible. In this prospective...
4084 Background: Preclinical and clinical data indicate that neoadjuvant chemoradiotherapy (CRT) may prime an anti-tumor immunological response in esophageal cancer driven by intratumoral CD8+ T cells. However, responses to therapy can vary widely across patients. The microbiome, a novel potentially modifiable biomarker of immunotherapy response, inform response. Methods: Fecal tumor samples were collected from patients with stage II-III resectable distal or gastroesophageal junction...
This short opinion essay provides views of a senior medical student from Pakistan; regarding what he thinks should be the focus comprehensive curriculum. He correlates his ideas with new curricular theme problem-based learning, introduced at university in recent years.
Background: Iron deficiency is a cause of anemia in many hemodialysis patients. It remains under diagnosed patients with kidney diseas and it leads to inappropriate response erythropoietin. Early diagnosis this before usage erythropoietin important, prevent prescription expensive unnecessary costs the patient health care system. This study was conducted determine prevalence iron Methods: cross-sectional comparative at National Institute Kidney Disease. Sheikh Zayed hospital nephrology...
Extramedullary hematopoiesis is common in chronic hemolytic anemias such as pyruvate kinase deficiency. It commonly associated with hepatosplenomegaly or lymphadenopathy; however, it can rarely also present a mass the chest, abdomen, paraspinal region. Here, we case of an adult patient deficiency and history splenectomy. He presented sepsis brisk leukocytosis secondary to pneumonia was found have diffuse intraabdominal lymphadenopathy along paravertebral mass. The radiological findings...
Herniation pits are small benign oval lesions that were reported to be always lying within the super-lateral femoral neck, and first described in 1982 by Michael J. Pitt. They usually a unilateral incidental finding along with asymptomatic course. It was widely believed herniation result of invagination overlying synovium into cortical defects neck. In our case; mentioned found atypically bilaterally at inferomedial aspect neck femur 7-year old child. Radiological scans efficient obtain an...