A5037050016- Economic and Financial Impacts of Cancer
- Lymphoma Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Cancer Immunotherapy and Biomarkers
- Multiple Myeloma Research and Treatments
- Colorectal Cancer Surgical Treatments
- CNS Lymphoma Diagnosis and Treatment
- COVID-19 and healthcare impacts
- CAR-T cell therapy research
- Viral-associated cancers and disorders
- COVID-19 Clinical Research Studies
- Lung Cancer Treatments and Mutations
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Lung Cancer Diagnosis and Treatment
- Sepsis Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Colorectal Cancer Screening and Detection
- Health Systems, Economic Evaluations, Quality of Life
- Genetic factors in colorectal cancer
- Venous Thromboembolism Diagnosis and Management
- Long-Term Effects of COVID-19
University of Pittsburgh
2016-2024
Allegheny Health Network
2017-2023
Allegheny General Hospital
2019-2022
Cleveland Clinic
2022
University of Kentucky
2022
Temple University Hospital
2022
University of Maryland, Baltimore
2021
University of Cincinnati
2020
University of Cincinnati Medical Center
2020
Institute of Cardiology
2015
The COVID-19 crisis has had an unprecedented impact on resident education and well-being: social distancing guidelines have limited patient volumes forced virtual learning, while personal protective equipment (PPE) shortages, school/daycare closures, visa restrictions served as additional stressors. Our study aimed to analyze the effects of crisis-related stressors residents' professional lives. In April 2020, we administered a survey residents at large academic hospital system in order...
Compared with people living without HIV (PWOH), (PWH) and cancer have traditionally been excluded from immune checkpoint inhibitor (ICI) trials. Furthermore, there is a paucity of real-world data on the use ICIs in PWH cancer.
Abstract Although zinc deficiency (secondary to malnutrition) has long been considered an important contributor morbidity and mortality of infectious disease (e.g. diarrhea disorders), epidemiologic data (including randomized controlled trials with supplemental zinc) for such a role in lower respiratory tract infection are somewhat ambiguous. In the current study, we provide first preclinical evidence demonstrating that although diet‐induced acute (Zn‐D: ~50% decrease) did not worsen induced...
Patients surviving sepsis demonstrate sustained inflammation, which has been associated with long-term complications. One of the main mechanisms behind inflammation is a metabolic switch in parenchymal and immune cells, thus understanding alterations after may provide important insights to pathophysiology recovery. In this study, we explored metabolomics novel Drosophila melanogaster model using Nuclear Magnetic Resonance (NMR), determine metabolite profiles. We used percutaneous infection...
Background: Disparities driven by socioeconomic factors have been shown to impact outcomes for cancer patients. We sought explore this relationship among patients with multiple myeloma (MM) who were not considered hematopoietic stem cell transplant in the first-line setting and how it varied over time. Methods: queried National Cancer Database diagnosed MM between 2004 2016 included only those received systemic therapy as treatment. Enrollment rates calculated receipt of incident event...
Sepsis is the leading cause of death in hospitalized patients and beyond hospital stay these long-term sequelae are due part to unresolved inflammation. Metabolic shift from oxidative phosphorylation aerobic glycolysis links metabolism inflammation such a commonly observed sepsis under normoxic conditions. By shifting metabolic state phosphorylation, we hypothesized it would reverse subsequently improve outcome. We propose as therapy by targeting pathways involved conversion pyruvate into...
Male breast cancer (MBC) accounts for 1% of all cancers and there is a paucity data on factors impacting the treatment strategies outcomes. We sought to use large national database examine trends predictors adjuvant radiation (Adj-RT), as well any association with outcome.We queried National Cancer Database (NCDB) patients stages I-III MBC treated surgery (breast conservation surgery-BCS or mastectomy-MS) within 180 days diagnosis (years 2004-2015). Multivariable logistic regression...
Hospitalized patients with hematological malignancy (HM) suffer an increased incidence of venous thromboembolism (VTE). We sought to identify risk factors and rate VTE in hospitalized HM using National Inpatient Sample (NIS) for the years 2011 2015. used ICD-9 codes as primary diagnosis a secondary hospitalization. The was highest acute myeloid leukemia (6.6%) followed by lymphocytic (6.1%) non-Hodgkin’s lymphoma (6.0%). occurred among receiving chemotherapy (OR 1.68; 95% CI 1.567–1.809)...
Multiple organ failure, wasting, increased morbidity, and mortality following acute illness complicates the health span of patients surviving sepsis. Persistent inflammation has been implicated, it is proposed that insulin signaling contributes to persistent inflammatory during recovery phase after However, mechanisms are unknown suitable pre-clinical models lacking. We therefore developed a novel Drosophila melanogaster model sepsis recapitulate clinical course sepsis, explored over time,...
Many pulmonary problems such as lung cancer, occupational asthma, and pneumoconiosis have been described due to welding in the literature until now. This is first case report of alveolar hemorrhage fumes presented with massive hemoptysis. We a rare hemopthisis associated welder's lung, discussion based on review literature. diseases attributed Alveolar has never defined before. herein hemoptysis fumes. Clinicians should be aware but serious clinical picture which can occur workers....
Qi LL involvement, stage III disease, and treatment in recent years were predictive of TNT use.There was greater use with more advanced stage, specifically > 1 node involved (odds ratio [OR] = 2.88, 95% confidence interval [CI]: 2.11-3.93,P < 0.01) disease (OR 95%CI: 0.01).From 2010 to 2012 the increased 2.41, 1.27-4.56,P a increase from 2013 2015 6.62, 3.57-12.25,P 0.01).Both neoadjuvant chemoradiation arms had similar 5-year survival at 76% 78% respectively.Multivariable analysis...
Patients with advanced cancers are among the most vulnerable group of patients. We sought to analyze impact Affordable Care Act (ACA) on interaction socioeconomic factors treatment and survival in patients metastatic colorectal cancers. National Cancer Database (NCDB) was queried for Stage-IV colon(CCa) rectal cancers(R-Ca) diagnosed 2004–2015 excluded those who did not receive any therapies within 6 months diagnosis. Enrollment-rates were calculated as receipt primary therapy incident-event...
Introduction Ankylosing spondylitis is an autoimmune disease with chronic inflammation of the spine and sacroiliac joints that commonly treated immunosuppressants including disease-modifying antirheumatic drugs anti-tumor necrosis factor alpha therapy. Case report A 75-year-old female active ankylosing on treatment etanercept was referred to us for newly diagnosed IgG kappa free light chain multiple myeloma. After failing induction revlimid, bortezomib, dexamethasone, she initiated...
To examine the impact of ACA and association socioeconomic factors on delay in initial treatment for multiple myeloma (MM).Patients diagnosed with MM between 2004-2016 were identified National Cancer Database (NCDB). Time-to-initial (TTI) was defined as number days from diagnosis to therapy. Patients classified into quartiles those belonging fourth quartile TTI constituted delayed group. Study period divided pre-ACA post-ACA using 2010 cut-off.A total 65,723 patients met eligibility...
Importance Despite growing literature, there is still limited understanding of factors that can predict outcomes in coronavirus disease 2019 (COVID-19) patients who require intensive care. Objective To evaluate the characteristics COVID-19 admitted to care unit (ICU) and identify their associations with outcomes. Background There are data on Pennsylvania. Design Retrospective study Setting Intensive units an academic health system Western Participants Patients reverse...
Abstract BackgroundTo achieve progress in cancer treatment, socioeconomic disparities impacting the care need to be recognized and addressed. We hypothesized that social determinants of health may predict a delay systemic therapy for metastatic hepatocellular carcinoma patients (HCC) sought examine impact Affordable Care Act (ACA).MethodsNational Cancer Database (NCDB) was queried with diagnosed from 2004-2015 considered first line within 6 months (180 days) diagnosis. Time initiation (TTI)...
Thrombosis and bleeding are recognized complications of the novel coronavirus infection (COVID-19), with a higher incidence described particularly in critically ill.A retrospective review COVID-19 patients admitted to our intensive care units (ICU) between 1 January 2020 31 December was performed. Primary outcomes included clinically significant thrombotic events (according ISTH definition) ICU. Secondary mortality vis-a-vis type anticoagulation.The cohort 144 consecutive median age 64 years...
<h3>Background</h3> Due to limited inclusion of PLWH in most ICI clinical trials, there is a paucity data evaluating their safety and efficacy this unique population, especially among metastatic NSCLC. <h3>Methods</h3> In retrospective, international multi-center study, we identified 64 HIV positive (HIV+) patients 117 matched negative (HIV-) controls with NSCLC treated between January 2015 October 2021 at 16 institutions the U.S. Europe. At each institution, 1 HIV+ patient 2 or HIV- (1:2...
Extramedullary hematopoiesis is common in chronic hemolytic anemias such as pyruvate kinase deficiency. It commonly associated with hepatosplenomegaly or lymphadenopathy; however, it can rarely also present a mass the chest, abdomen, paraspinal region. Here, we case of an adult patient deficiency and history splenectomy. He presented sepsis brisk leukocytosis secondary to pneumonia was found have diffuse intraabdominal lymphadenopathy along paravertebral mass. The radiological findings...