A5042996985- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Multiple and Secondary Primary Cancers
- Healthcare Education and Workforce Issues
- Urinary Tract Infections Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cervical Cancer and HPV Research
- Cancer Immunotherapy and Biomarkers
- Advanced Radiotherapy Techniques
- Spine and Intervertebral Disc Pathology
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- Diverse Approaches in Healthcare and Education Studies
- Anesthesia and Pain Management
- Radiation Therapy and Dosimetry
- Endometrial and Cervical Cancer Treatments
- Education, Safety, and Science Studies
University of Alabama at Birmingham
2024
University of North Carolina Hospitals
2020
University of Pennsylvania
2012-2016
Hospital of the University of Pennsylvania
2011-2014
Philadelphia University
2011-2013
Swarthmore College
2012
BACKGROUND Clinical trials of radiation after radical cystectomy (RC) and chemotherapy for bladder cancer are in development, but inclusion stratification factors have not been clearly established. In this study, the authors evaluated refined a published risk locoregional failure (LF) by applying it to multicenter patient cohort. METHODS The original stratification, which was developed using single‐institution series, produced 3 subgroups with significantly different LF based on pathologic...
BACKGROUND Risk stratification is a major challenge in bladder cancer (BC), and biomarker needed. Multiple studies have reported the neutrophil‐to‐lymphocyte ratio (NLR) as promising candidate; however, these analyses methodological limitations. Therefore, authors performed category B study to test whether NLR prognostic for overall survival (OS) after curative treatment or predictive benefit from neoadjuvant chemotherapy (NAC). METHODS This an unplanned secondary analysis of SWOG 8710,...
Background: The absence of childhood vision care has detrimental consequences on development and learning.1 Vision Health Initiative Committee (VHI) was established by the Centers for Disease Control Prevention (CDC) to mandate school screenings.2 Improved detection does not translate into care. Poor compliance follow-up remains an issue. This study evaluates effectiveness outreach referral program specializing in assisting families with recommended children following in-school eye...
347 Background: To inform the design of trials adjuvant radiation (RT) for bladder cancer, a local failure (LF) risk grouping has been proposed and externally validated that stratifies radical cystectomy (RC) pts into 3 groups based on pathologic factors. This stratification was developed using historical surgical databases may not reflect outcomes in observation arm modern trial. The purpose study is to assess whether trial accrual bias or improving techniques over time impact validity...
293 Background: Local-regional recurrences (LF) after radical cystectomy with or without chemotherapy are common in patients locally advanced disease. Adjuvant radiation (RT) could reduce LF, but toxicity discouraged its use. Modern RT reduced morbidity has rekindled interest requires knowledge of pelvic failure patterns to design appropriate clinical target volumes. Methods: 5-yr LF rates plus lymph node dissection were determined for 8 sites among 442 urothelial carcinoma the bladder. The...
262 Background: Invasive urothelial bladder carcinoma is typically treated with radical cystectomy (RC) plus pelvic lymph node dissection (PLND) +/− chemotherapy. Local-regional failures (LF) following are a significant problem. Adjuvant radiation therapy (RT) could potentially reduce LF but currently has no defined role because of previously reported morbidity. Modern RT techniques improved normal tissue sparing have rekindled interest in adjuvant RT. Stratifying patients by differing risk...
361 Background: Pre-operative risk stratification is a major challenge in bladder cancer (BC), and biomarker needed. Recent studies suggest baseline neutrophil-to-lymphocyte ratio (NLR) correlates with survival BC, but these results are threatened by methodological limitations. We tested whether NLR prognostic for overall (OS) BC following principles detailed the REMARK guidelines. Methods: SWOG 8710 was randomized, phase III trial assessing radical cystectomy (RC) ± neoadjuvant chemotherapy...
297 Background: Trials of adjuvant radiation (RT) after radical cystectomy + pelvic node dissection (RC) are in development, but patient selection criteria have not been clearly identified. We evaluated a published model predicting the risk local-regional failure (LF) by applying to multi-center cohort. also assessed model’s ability stratify overall survival (OS) and isolated distant metastases (DM). Methods: The original LF was derived from 442 patients who had RC +/- chemotherapy at...
Purpose: To compare the bowel and rectal dose distribution in patients who have had a prior cystectomy receiving pelvic node irradiation using 3D conformal photon therapy (3DCT), intensity modulated radiotherapy (IMRT) or proton (IMPT) planning technique. Methods: We performed treatment for five generating plans with IMPT, IMRT, 3DCT. The target volume (PTV) is nodal region including 4 mm expansion setup errors, dosimetric uncertainty. normal tissues of concern are rectum combined small...
You have accessJournal of UrologyBladder Cancer: Invasive (II)1 Apr 20131628 RISK STRATIFICATION FOR LOCAL-REGIONAL FAILURE AFTER CYSTECTOMY Brian Baumann, Jiwei He, Wei-Ting Hwang, Kai Tucker, Seth Lerner, Cathy Tangen, Harry Herr, Thomas Guzzo, S. Bruce Malkowicz, and John Christodouleas BaumannBrian Baumann Philadelphia, PA More articles by this author , HeJiwei He HwangWei-Ting Hwang TuckerKai Tucker LernerSeth Lerner Houston, TX TangenCathy Tangen Seattle, WA HerrHarry Herr New York, NY...
e15045 Background: Patients with stage ≥T2 transitional cell carcinoma (TCC) of the bladder are typically treated radical cystectomy (RC) + pelvic node dissection (PND) +/- chemotherapy. Adjuvant radiation therapy (RT) has no clearly defined role, although local-regional failure (LF) following RC remains a significant problem. RT could potentially reduce LF, but morbidity reported in past for such discouraged its use. Modern techniques improved normal tissue sparing have rekindled interest...