A5103113842- Advanced Radiotherapy Techniques
- Economic and Financial Impacts of Cancer
- Palliative Care and End-of-Life Issues
- Mechanical Circulatory Support Devices
- Alzheimer's disease research and treatments
- Lung Cancer Diagnosis and Treatment
- Veterinary Pharmacology and Anesthesia
- Ion Channels and Receptors
- Dialysis and Renal Disease Management
- Cardiac Arrest and Resuscitation
- Pesticide Exposure and Toxicity
- Travel-related health issues
- Potassium and Related Disorders
- Pharmacological Effects and Toxicity Studies
- Vascular Malformations and Hemangiomas
- Birth, Development, and Health
- Immunotoxicology and immune responses
- Migraine and Headache Studies
- Human Health and Disease
- Telomeres, Telomerase, and Senescence
- Sarcoidosis and Beryllium Toxicity Research
- Electrospun Nanofibers in Biomedical Applications
- Cholinesterase and Neurodegenerative Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Forensic Toxicology and Drug Analysis
University of Pennsylvania
2004-2024
Monash Medical Centre
2024
Monash Health
2024
University of California, San Diego
2022-2024
University of Washington
2024
UNSW Sydney
2022-2024
Kaiser Permanente
2023
Kaiser Permanente San Francisco Medical Center
2023
Colorado Permanente Medical Group
2023
Brown University
2022
<h3>Background</h3>Given the slow and variable clinical course of Alzheimer disease, very large extended trials are needed to identify a beneficial effect disease-modifying treatments. Therefore, biomarkers essential prove that an anti–β-amyloid (Aβ) drug candidate affects both Aβ metabolism plaque load as well downstream pathogenic mechanisms.<h3>Objective</h3>To evaluate anti-Aβ monoclonal antibody bapineuzumab on cerebrospinal fluid (CSF) reflecting homeostasis, neuronal degeneration,...
Concurrent chemoradiotherapy is the standard-of-care curative treatment for many cancers but associated with substantial morbidity. administered proton therapy might reduce toxicity and achieve comparable cancer control outcomes compared conventional photon radiotherapy by reducing radiation dose to normal tissues.To assess whether in setting of concurrent fewer 90-day unplanned hospitalizations (Common Terminology Criteria Adverse Events, version 4 [CTCAEv4], grade ≥3) or other adverse...
Adult mammalian wounds, with rare exception, heal fibrotic scars that severely disrupt tissue architecture and function. Regenerative medicine seeks methods to avoid scar formation restore the original structures. We show in three adult mouse models pharmacologic activation of nociceptor TRPA1 on cutaneous sensory neurons reduces can also promote regeneration. Local induces regeneration distant untreated areas injury, demonstrating a systemic effect. Activated stimulates local production...
Sarcoidosis is a chronic multisystem inflammatory disorder characterized by the formation of immune granulomas that may lead to serious, often irreversible, disability and significant disease-associated mortality.1 Current understanding suggests sarcoidosis represents helper T cell 1–mediated granulomatous response an unidentified antigen, but exact pathogenesis remains unknown.1 Polycythemia vera (PV) acquired myeloproliferative neoplasm mutant Janus kinase 2 (JAK2) signaling leading...
Stereotactic body radiotherapy (SBRT) is potentially curative treatment for small hepatocellular carcinomas (HCC), but data are limited on its efficacy and toxicity. We hypothesized that SBRT can achieve excellent local control (LC) with acceptable toxicity treating HCC lesions, even in advanced cirrhosis.Thirty-seven nonmetastatic patients received to 43 lesions between October 2012 April 2016. Median dose was 50 Gy/5 fractions. All Child-Pugh (CP) ≥B underwent a planned 1-month break after...
The objective of the study was to estimate economic cost benefit funding influenza vaccination all Australian adults 50-64 years and predict its effect on sudden cardiac arrest (SCA) deaths hospitalisation.
Alzheimer's disease (AD) is characterized by plaques, tangles, and neuronal degeneration, with accompanying decreases in cerebrospinal fluid (CSF) Ab increases tau proteins. Antibodies against the Aβ N-terminus reduce cerebral deposits transgenic mice block synaptotoxic effects of oligomers. Immunotherapy AN1792, a synthetic Ab42 peptide that elicits anti-Aβ antibody production, reduced CSF total AD patients. We evaluated whether bapineuzumab, an N terminal monoclonal antibody, impacts...
BackgroundAcute febrile neutrophilic dermatosis (Sweet syndrome) is a potentially fatal multiorgan inflammatory disease characterized by fever, leukocytosis, and rash with infiltrate. The pathophysiology remains elusive, current dogma suggests that Sweet syndrome process of reactivity to an unknown antigen. Corticosteroids steroid-sparing agents remain frontline therapies, but refractory cases pose clinical challenge.MethodsA 51-year-old woman developed serious corticosteroid-related side...
Cardiac arrest is the least preventable burden of cardiovascular disease, as treatment depends on timely resuscitation. The incidence sudden cardiac (SCA) high, contributing 10-20% mortality globally. influenza vaccine reduces risk acute events. Little known about relationship infection to arrest.This study aimed determine estimated rate SCA hospitalisations attributable in Australian adults. A generalised-additive statistical model was applied study. Weekly counts laboratory-confirmed...
Experience-dependent functional plasticity is a hallmark of the primary visual system, but it not known if analogous mechanisms govern development circadian system. Here we investigated molecular, anatomical, and behavioral consequences complete monocular light deprivation during extended intervals postnatal in Syrian hamsters. Hamsters were raised constant darkness opaque contact lenses applied shortly after eye opening prior to introduction light-dark cycle. In adulthood,...
Abstract Purpose Although congenital anomalies of the kidney and urinary tract (CAKUT) are among leading causes end-stage disease (ESKD) in children young adults, transplantation access for this population has not been well studied US. We compared US based on whether etiology was secondary to CAKUT, additionally by CAKUT subgroups (anatomic vs. inherited CAKUT). Methods Using United States Renal Data System, we conducted a retrospective cohort study 80,531 adults who started dialysis between...
Background Goals of care conversations are essential to delivery goal concordant care. Infrequent and inconsistent goals documentation potentially limit Methods At Kaiser Permanente San Francisco Cancer Center, a standardized template was designed implemented increase by oncologists. The centralized, prompt-based included value clarification the values advanced cancer patients beyond treatment preferences. Documented using during initial pilot period were reviewed characterization clinical...
6521 Background: Concurrent chemo-radiotherapy is standard-of-care curative treatment for many cancers, but associated with substantial morbidity. Proton therapy may increase the tolerability or effectiveness of concurrent by reducing radiation to normal tissues. Methods: We conducted a comparative study adult non-metastatic cancer patients treated intent proton vs. photon from 2011-2016 at University Pennsylvania. Re-irradiation and disease sites photon-only were excluded. Data on adverse...
ABSTRACT Background Very low calorie diets (VLCDs) are an obesity treatment option in the general population, but their efficacy and safety patients on haemodialysis (HD) is unknown. Methods Prospective single arm study of VLCD patients. All participants received 2.5–3.3 MJ/day for 12 weeks. Weekly assessment VLCD, pre- post-dialysis weight, inter-dialytic weight gain, blood electrolytes occurred first 4 weeks, then fortnightly another 8 Linear mixed models compared change over time as well...
Although resilience has been identified as an important mediator of negative mental health outcomes among refugee populations, there are few culturally specific measures such communities and no measure Somalis. In this study we aimed to develop a appropriate Somali adults in San Diego, example vulnerable community. A community-based, exploratory sequential mixed method investigation was conducted via focus group discussions ( n = 4), cognitive interviews iterative survey adaptation. Diego N...
The alpha-2 agonist xylazine is increasingly detected as an adulterant in illicitly manufactured fentanyl. There concern that may be responsible for emerging pattern of necrotizing wounds among people who use drugs, but the clinical features associated with remain poorly characterized.
531 Background: The OncotypeDx genomic assay has been widely used to predict recurrence in those with early-stage ER positive breast cancer determine whether adjuvant chemotherapy is beneficial. Receiving results a timely manner prior medical oncology appointment critical inform therapy decisions. In this quality improvement project, we implemented care delivery optimization for patients receiving assays an integrated healthcare system. was conducted as part of implementing the 4R Oncology...
Abstract Introduction: Subpopulations of highly tumorigenic, drug resistant cancer stem-like cells (CSCs) play a key role in recurrence and progression. Surprisingly, these aggressive can arise repeatedly de novo from bulk tumor independently mutational events. We investigated whether transition to state is associated with epigenetic alterations, such as DNA methylation chromatin accessibility. Materials methods: Using FACS Hoechst dye staining, side population (SP) marked by high...
e22033 Background: Circulating tumor cells (CTC) have been associated with outcome in epithelial malignancies, but conventional immunoaffinity capture has not amenable to HCC given the rare expression of cell adhesion molecules this malignancy. Here, we used a parylene-C slot microfilter and characterize CTCs based on size deformability patients (pts) initiating therapy. Methods: Pts were enrolled 3 cohorts: Cohort 1 (C1): advanced disease (BCLC B C), planned systemic therapy; cohort 2 (C2):...