A5101774121- Neonatal Respiratory Health Research
- Gestational Diabetes Research and Management
- Infant Nutrition and Health
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Child Nutrition and Water Access
- Congenital Diaphragmatic Hernia Studies
- Connexins and lens biology
- Genetic Associations and Epidemiology
- Biochemical Analysis and Sensing Techniques
- Antimicrobial Peptides and Activities
- Helicobacter pylori-related gastroenterology studies
- Plant and animal studies
- Fermentation and Sensory Analysis
- Circular RNAs in diseases
- Birth, Development, and Health
- MicroRNA in disease regulation
- Viral Infectious Diseases and Gene Expression in Insects
- Pregnancy and preeclampsia studies
- Extracellular vesicles in disease
- Fungal and yeast genetics research
- Nicotinic Acetylcholine Receptors Study
- Cancer-related gene regulation
- Gut microbiota and health
- Neuroscience of respiration and sleep
Wuxi People's Hospital
2018-2023
Second Affiliated Hospital of Nanjing Medical University
2018-2023
Henan University
2020
Inner Mongolia Agricultural University
2006-2010
Abstract Circular RNA (circRNA) is a novel member of endogenous noncoding RNAs with widespread distribution and diverse cellular functions. Recently, circRNAs have been identified for their enrichment stability in exosomes. However, the roles from umbilical cord blood exosomes gestational diabetes mellitus (GDM) occurrence fetus growth remains poorly understood. In present study, we used microarray technology to construct comparative circRNA profiling between GDM patients controls. We found...
Abstract Necrotizing enterocolitis (NEC) is the most common life‐threatening gastrointestinal disease encountered in premature infant. It has been shown that intercellular reactive oxygen species (ROS) generation activated by lipopolysaccharide involved nuclear factor kappa B (NF‐κB) activation and pathogenesis of NEC. Here, we report an antioxidant peptide from tuna backbone protein (APTBP) reduces inflammatory cytokines transcription release. APTBP directly scavenges free radical through...
Introduction: New genetic variants associated with susceptibility to obesity and metabolic diseases have been discovered in recent genome-wide association (GWA) studies. The aim of this study was investigate the theses risk gestational diabetes mellitus (GDM). Methods: We performed a case-control including 964 unrelated pregnant women GDM 1,021 normal glucose tolerance (as controls). A total 33 confirmed by GWA studies for were selected measured. Results: observed that FTO rs1121980 KCNQ1...
Background and Aims: Exosomes contain numerous RNAs transfer them between cells or organs, thereby establishing intercellular interorgan communication. The roles of mRNAs long noncoding (lncRNAs) from umbilical cord blood exosomes in gestational diabetes mellitus (GDM) occurrence fetus growth remain poorly understood. We aimed to establish the differential mRNA lncRNA expression profiles GDM patients compared with normal controls. Results: Using microarray technology, we identified 84 256...
Necrotizing enterocolitis (NEC) is a common devastating gastrointestinal disease in premature infants, the molecular mechanisms of which have not been fully elucidated. Recently, endogenous peptides garnered much attention owing to their role diagnosis and treatment. However, changes peptide expression NEC intestinal tissues remain poorly understood. In present study, comparative peptidomics profiling analysis was performed between control via liquid chromatography-tandem mass spectrometry...
Abstract Background Bronchopulmonary dysplasia is a serious and lifelong pulmonary disease in premature neonates that influences around one-quarter of newborns. The wingless-related integration site /β-catenin signaling pathway, which abnormally activated the lungs with fibrosis, affects cell differentiation lung development. Methods Newborn rats were subjected to hyperoxia exposure. Histopathological changes evaluated through immunohistochemistry, activation disheveled Wnt pathway...
Abstract Genome‐wide association studies (GWASs) showed that three single nucleotide polymorphisms (SNPs; rs10968576, rs1412239, and rs824248) in the leucine‐rich repeat Ig domain containing 2 (LINGO2) were associated with obesity or type diabetes (T2D). We aimed to determine influence of LINGO2 variants on gestational mellitus (GDM) risk. Thus, we performed a case–control study including 964 GDM cases 1,021 controls test associations between (rs10968576, susceptibility GDM. Logistic...
To explore the optimal maintenance dose of caffeine citrate for preterm infants requiring assisted ventilation and treatment.A retrospective analysis was performed on medical data 566 (gestational age ≤34 weeks) who were treated required treatment in neonatal intensive care unit 30 tertiary hospitals Jiangsu Province China between January 1 December 31, 2019. The 405 receiving high-dose (10 mg/kg per day) after a loading 20 within 24 hours birth enrolled as group. 161 low-dose (5...
The regulation of muscle glucose utilization has significant potential for the treatment type 2 diabetes mellitus (T2DM) and obesity. Heat shock factor 1 (HSF1) is involved in cellular metabolism metabolism. However, it unclear how HSF1 regulates In present study, development obesity mice was associated with downregulation. Serum samples biopsies were obtained from obese healthy humans. Fasting insulin levels homeostasis model assessment resistance value showed that resistance. skeletal...
Abstract Mothers choose suitable habitats for laying offspring to maximize fitness. Because habitat quality varies in space and time, mothers gather information among available through multiple cues reflecting different aspects of at present the future. However, it is unclear how females assess integrate associated with current rewards future safety optimize oviposition/larviposition decisions, especially across small spatial scales. Here, we tested individual interactive effects leaf...
Verbascum chinense is a perennial plant in the Scrophulariaceae family that traditionally used as sedative, astringent, febrifuge, and for skin eruptions. Here, we determined complete chloroplast(cp) genome sequence V. using skimming sequencing. The cp was 153,618 bp consisted of large single copy (LSC) region (84,834 bp), small (SSC) (17,884 two inverted repeats (IRs) (25,450 bp). It encodes 114 unique genes, including 80 protein-coding four rRNAs, 30 tRNAs. Phylogenetic analysis indicates...
Abstract Background: Bronchopulmonary dysplasia (BPD) is a serious and lifelong pulmonary disease in premature neonates, which has an influence on quarter of newborns. Wingless/integrated(Wnt)/β-catenin signaling pathway affects lung cell differentiation tissue structure, abnormal activation the lungs rats with fibrosis. Method: Newborn were subjected to hyperoxia-exposure, histopathological changes tissues evaluated through Immunohistochemistry (IHC), Dishevelled (DVL-1) pathways detected...