A5100638995- Fatty Acid Research and Health
- Circular RNAs in diseases
- Infant Nutrition and Health
- FOXO transcription factor regulation
- Breastfeeding Practices and Influences
- Cancer-related Molecular Pathways
- Reproductive Biology and Fertility
- Pregnancy and preeclampsia studies
- RNA Research and Splicing
- Drug Transport and Resistance Mechanisms
- MicroRNA in disease regulation
- Vitamin C and Antioxidants Research
- Cancer-related molecular mechanisms research
- Ion Transport and Channel Regulation
- Prenatal Screening and Diagnostics
- Sarcoma Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Analytical Chemistry and Chromatography
- Iron oxide chemistry and applications
- Congenital Anomalies and Fetal Surgery
- Connective Tissue Growth Factor Research
- Nanoparticles: synthesis and applications
- Lipid metabolism and biosynthesis
- Gestational Diabetes Research and Management
- Parathyroid Disorders and Treatments
Nanjing Medical University
2011-2018
Nanjing Maternity and Child Health Care Hospital
2011-2018
Wuxi Institute of Technology
2018
Background: The objective of this study was to evaluate the synthesis and biocompatibility Fe 3 O 4 nanoparticles investigate their therapeutic effects when combined with magnetic fluid hyperthermia on cultured MCF-7 cancer cells. Methods: Magnetic were prepared using a coprecipitation method. appearance, structure, phase composition, functional groups, surface charge, susceptibility, release in vitro characterized by transmission electron microscopy, x-ray diffraction, scanning...
Fatty acid (FA) is the major energy resource in breast milk, which important for infant development. FAs profiles with sn-2 positional preference were an part of triacylglycerols due to their better availability. This profile still not replicated artificial formulas. study quantified total and position human milk samples from 103 healthy volunteers during colostrum, transitional, mature stages. Multicomponent analysis showed significant differences different lactation periods, that relative...
Abstract Background and Objectives Aquaporins (AQPs) play important roles in water glycerol transport. Recently, the role of AQPs human carcinogenesis has become an area great interest. However, little is known about function breast cancer. The aim this study was to investigate expression profile cancer its significance. Methods In study, we screened AQP0–12 tissues corresponding normal by RT‐PCR, Western blotting immunohistochemistry. Results AQP1, 3–5, 10–12 were expressed and/or tissues,...
Our previous studies have demonstrated overexpression of Mcl-1 in cervical cancer tumorigenesis. However, the molecular mechanism its remains not elucidated. MiR-320 has been reported to be down-regulated various types cancer, and bioinformatics prediction indicated that it may regulate expression Mcl-1. The aim this study is investigate role miR-320 target gene progression assess their clinical significance. expressions human tissues were investigated by qRT-PCR, situ hybridization,...
Background Intrahepatic cholestasis of pregnancy (ICP) is the most prevalent specific liver disease. However, pathogenesis and etiology ICP poorly understood. Aim To assess expression peroxisome proliferator-activated receptorγ (PPARγ) nuclear factor kappa B (NF-κB) in placenta HTR-8/SVneo cell, evaluate serum levels cytokines, bile acids, hepatic function lipids control patients fetal outcome, order to explore role PPARγ/NF-κB signaling pathway possible mechanism ICP. Methods Clinical data...
Introduction Intrahepatic cholestasis of pregnancy (ICP) usually occurs in the third trimester and associated with increased risks fetal complications. Currently, exact cause this disease is unknown. In study we aim to investigate potential proteins placenta, which may participate molecular mechanisms ICP-related complications using iTRAQ-based proteomics approach. Methods The iTRAQ analysis combined liquid chromatography-tandem mass spectrometry (LC-MS/MS) was performed separate...
Background The increasingly recognized importance of vitamin D has been discussed and status among young children attracted widespread attention in recent years. However, study on aged 1–3 y is limited China. Objective To evaluate the nutritional Wuxi, southeastern Methods A large cohort 5,571 were recruited this who visited child health clinics at Wuxi Maternity Child Health Hospital (latitude 31.57°N) during January 2014 to 2015. was located China a latitude 31.57°N. Finger-stick blood...
Breast milk consumption reduces the incidence of necrotizing enterocolitis (NEC) in preterm infants compared to formula. Branched-chain fatty acids (BCFAs) are present breast but not most formulas intended for infants. We aimed determine composition BCFAs mothers with infants, and understand impact gestational age at birth stage lactation on BCFA content. The main were iso-14:0, iso-15:0, anteiso-15:0, iso-16:0, iso-17:0, anteiso-17:0. as a percent total (g per 100 g, %) significantly...
Labor-intensive karyotyping is used as the reference standard diagnostic test to identify copy number variants (CNVs) in fetal genome after recurrent pregnancy loss. Our aim was present and evaluate a novel molecular assay called CNVplex that could potentially be an alternative method conventional for diagnosing chromosomal abnormalities associated with loss.Using standard, performed chorionic villus samples from 76 women experiencing at least two losses. Its accuracy, sensitivity,...
Objective To explore the effects and significance of individualized nutrition guidance patients with polycystic ovary syndrome (PCOS) during pregnancy. Methods Between January 2010 March 2013, sixty eight pregnant women who were diagnosed as PCOS in Wuxi Maternal Child Health Hospital Affiliated to Nanjing Medical University recruited into study. They divided intervention group (n =36) control =32) . Intervention accepted nutritional guidance, follow traditional guidance. The...
Branched chain fatty acids (BCFA), as the main component of trace in human milk, are proved to be functional compounds for infant intestinal health and cancer inhibition which make it necessary investigate their role diet humans. However, a comprehensive existing form BCFA lipids has not been well defined. Therefore, objective present study was characterize content total lipid, neutral lipid polar with focus on positional distribution triglycerides nature including colostrum (All experiments...
Background: Ovarian carcinoma represents one of the most insidious and aggressive cancers. is lethal gynecological malignancy. To discover new relevant biomarkers to increase specificity sensitivity for early diagnosis prognosis ovarian cancer important urgently needed. FOXO3a possesses a large series function including cellular proliferation, transformation, differentiation, longevity. Jab1 also known as subunit 5 (CSN5) COP9 signalosome (CSN), multifunctional protein complex involved in...