A5004641857- Hemoglobinopathies and Related Disorders
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Esophageal Cancer Research and Treatment
- Hematopoietic Stem Cell Transplantation
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Erythrocyte Function and Pathophysiology
- Cancer Risks and Factors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- RNA modifications and cancer
- T-cell and B-cell Immunology
- Retinoids in leukemia and cellular processes
- Prenatal Screening and Diagnostics
- Cancer-related molecular mechanisms research
- Parvovirus B19 Infection Studies
- Bacterial biofilms and quorum sensing
- Immunodeficiency and Autoimmune Disorders
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Bone and Joint Diseases
303 Hospital of People's Liberation Army
2015-2025
Fourth People’s Hospital of Jinan
2024-2025
Xian Yang Central Hospital
2024-2025
Peking University
2024
National Clinical Research
2024
Peking University Sixth Hospital
2024
Second Military Medical University
2024
People's Liberation Army 401 Hospital
2022-2023
Chinese People's Liberation Army
2023
Shandong University
2019-2022
Hemoglobinopathies are among the most common autosomal-recessive disorders worldwide. A comprehensive next-generation sequencing (NGS) test would greatly facilitate screening and diagnosis of these disorders. An NGS panel targeting coding regions hemoglobin genes four modifier was designed. We validated assay by using 2522 subjects affected with hemoglobinopathies applied it to carrier testing in a cohort 10,111 couples who were also screened through traditional methods. In clinical...
Background: Hundreds of studies have found that the microbiota contributes to development gastric cancer in past two decades.This study aimed access research trends and cancer.Materials Methods: Publications from January 1, 2000 December 31, 2019 were retrieved Web Science Core Collection database screened according inclusion criteria.Different kinds software, SPSS21.0,HistCite, VOSviewer, CiteSpace, online bibliometric analysis platform used evaluate visualize results.Results: A total 196...
China is one of the countries with heaviest burden gastric cancer (GC) in world. Understanding epidemiological trends and patterns GC can contribute to formulating effective prevention strategies.The data on incidence, mortality, disability-adjusted life-years (DALYs) from 1990 2019 were obtained Global Burden Disease Study (2019). The estimated annual percentage change (EAPC) was calculated evaluate temporal disease GC, package Nordpred R program used perform an age-period-cohort analysis...
To map the magnitudes and temporal trends of blindness vision loss (BVL) due to common eye diseases along with its attributable risk factors at national, regional, global levels. The annual burden BVL in 204 countries territories was extracted from Global Burden Disease Study 2019. estimated percentage change (EAPC) causes composition were calculated quantify BVL-related disease by sex, region, disease. disability-adjusted life years (DALYs) increased 12.44 million 1990 22.56 2019, a...
Abstract Background To assess the spatiotemporal variation in female breast cancer attributable to low physical activity (LPA) at a global scale from 1990 2019, which is essential promote activity, as well prevent and control cancer. Methods The number of deaths disability-adjusted life years (DALYs), corresponding age-standardized rates (ASMR ASDR) LPA-related 204 countries territories 2019 were retrieved Global Burden Disease Study measure related burden by age region. estimated annual...
MicroRNA-22 (miR-22) is emerging as a critical regulator in organ development and various cancers. However, its role normal hematopoiesis leukaemogenesis remains unclear. Here, we detected increased expression during monocyte/macrophage differentiation of HL-60, THP1 cells CD34+ hematopoietic stem/progenitor cells, confirmed that PU.1, key transcriptional factor for differentiation, responsible activation miR-22 the differentiation. By gain- loss-of-function experiments, demonstrated...
Abstract RNA binding proteins (RBPs)-mediated post-transcriptional control has been implicated in influencing various aspects of metabolism and playing important roles mammalian development pathological diseases. However, the functions specific RBPs molecular mechanisms through which they act monocyte/macrophage differentiation remain to be determined. In this study, bioinformatics analysis experimental validation, we identify that ZFP36L1, a member ZFP36 zinc finger protein family, exhibits...
Innate immunity of which Toll-like receptor (TLR) 4 and CXCR1 are key elements plays a central role in the development urinary tract infection (UTI). Although relation between genetics TLR4 UTI is investigated partly, polymorphisms expression different types adults not extremely clear.This study investigates presence A (896) G (2608) C 129 patients using RFLP-PCR. Gene allelic prevalence were compared with 248 healthy controls. Flow cytometry was used to detect monocytes AG genotype allele...
This study focused on the efficacy and safety of thalidomide for patients with β-thalassemia in a multicenter trial.Patients non-transfusion-dependent thalassemia (NTDT) or transfusion-dependent (TDT), who were unable to pursue conventional therapy transfusion chelation, recruited over 3 years three centers southern China. We evaluated short-term (three months) long-term follow-up (12 24 months). Response was defined as follows: Main Responder (MaR) showing an increase hemoglobin (Hb) level...
Background: The global disease burden of gastric cancer (GC) is still heavy. Understanding the patterns and trends GC important for developing precise prevention strategies. Materials Methods: data were retrieved from Global Burden Disease Study (2019). estimated annual percentage change (EAPC) was calculated to estimate temporal age-standardized incidence mortality rates (ASIR ASMR) by age-specific groups (15-49, 50-69, ≥70 years), sexes, socio-demographic indexes (SDIs), regions,...
Nucleoporin 98 (NUP98) fusion oncoproteins are associated with various hematologic malignancies. Acute myeloid leukemia (AML) NUP98-NSD1 typically co-occurs FLT3-ITD mutations, exhibiting poor initial responses to traditional chemotherapy. This case report describes a relapsed and refractory AML co-expressing NUP98/NSD1 FLT3/ITD after matched sibling haplo-identical allogeneic hematopoietic stem cell transplantation, achieving molecular remission salvage therapy combining selinexor,...
This study aimed to investigate the efficacy of inferior oblique belly transposition (IOBT) combined with contralateral recession in treating bilateral asymmetric overaction (IOOA). A retrospective was conducted on 23 patients IOOA. IOBT performed less affected eye patient, while more eye. Pre- and post-operative changes vertical deviation, V-value, fovea-disc angle (FDA), muscle function were compared. Follow-up duration ranged from 3 8 months. The V-pattern corrected all cases, V-value...
To investigate the effect of thalidomide in patients with thalassemia intermedia.We observed seven intermedia requiring blood transfusion. Four were transfusion-independent, and three transfusion-dependent.For four transfusion-independent patients, hemoglobin concentration increased significantly (≥2 g/dl) moderately (1-2 one. After 3 months treatment, 3.2 ± 1.2 g/dl compared to pretreatment. Among transfusion-dependent transfusion was terminated after one month treatment patient decreased...
Molecular mechanisms and observational studies have found that diet-derived antioxidants are associated with digestive system cancers, whereas there is a lack of causal evidence from randomized clinical trials. In this study, we aimed to assess the causality these associations through Mendelian randomization (MR) study. Single nucleotide polymorphisms circulating (i.e., α- γ-tocopherol, ascorbate, retinol, β-carotene, lycopene, urate), accessed by absolute levels relative metabolite...
Abstract Background Uterine cancer is one of the most common female cancers worldwide, with huge heterogeneity in morbidity and mortality. Although a high body‐mass index (BMI) has been linked to uterine cancer, systematic reports about influence BMI its temporal trends are scarce. Methods The annual morbidity, mortality, disability‐adjusted life years (DALYs) 204 countries or territories were retrieved from GBD 2019 study. To reflect disease burden, we also calculated estimated percentage...
Abstract Background β‐Thalassemia is extremely prevalent in Guangxi province, Southern China. However, little known about the treatment and complications of patients with thalassemia major (TM) Guangxi. The first center China was opened 2003. Since that time, more than 400 have been enrolled. Procedure From December 2009 to February 2010, data collected from TM visiting including circumstances diagnosis, biological clinical data, markers iron overload treatment. Results Data on 231 (median...
Abstract Background Early diagnosis of esophageal squamous cell carcinoma (ESCC) remains a challenge due to the lack specific blood biomarkers. We aimed develop serum multi-protein signature for early detection ESCC. Methods selected 70 healthy controls, 30 precancerous patients, 60 stage I II patients and III/IV ESCC from completed case-control study in high-risk area China. Olink Multiplex Oncology targeted proteomics panel was used simultaneously detect levels 92 cancer-related proteins...
Abstract Background Poor oral health may be a significant risk factor for gastric cancer (GC); however, previous results are not consistent. Here, we investigated the effect of on GC and modification by other factors. Methods We conducted population‐based case‐control study in Taixing, China. Participants aged between 40 85 years who had lived Taixing at least 5 were included. The cases confirmed endoscopy pathological diagnosis, controls randomly selected using frequency‐matching method....
Refractory and relapsed acute myeloid leukemia (r/rAML) is associated with a difficult prognosis; clinical trials are typically suggested despite lack of recognized standard care. Combinatorial chemotherapy regimens utilized for r/rAML salvage play crucial role in battling this invasive phase. Although it characterized by low response rate, CLAG traditional regimen used r/rAML. We aimed to compare the efficacy toxicity CLAG+PLD explore whether there was any improvement addition pegylated...
The beta-lactamase (BLA) genes, the genes for aminoglycosides-modifying enzymes (AMEs), disinfectant-sulfanilamide resistance (qacEDelta1-sul1) class 1 integrase (intl1) gene, and qnr gene associated with plasmid-mediated quinolone were analyzed using PCR verified by DNA sequencing 31 clinical isolates of multidrug-resistant Acinetobacter baumannii (MDRAB). organism typing was performed pulsed-field gel electrophoresis (PFGE). positive rate ADC, TEM, PER, DHA BLA 100%, 61.3%, 19.4%, 3.2%,...