A5057164907- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Bee Products Chemical Analysis
- Barrier Structure and Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Orthopedic Surgery and Rehabilitation
- Sports injuries and prevention
- Exercise and Physiological Responses
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Lymphatic System and Diseases
- Laser Applications in Dentistry and Medicine
- Hippo pathway signaling and YAP/TAZ
- Cellular Mechanics and Interactions
- Pregnancy and preeclampsia studies
- Connective tissue disorders research
- Wound Healing and Treatments
- Myofascial pain diagnosis and treatment
- Shoulder and Clavicle Injuries
- Silk-based biomaterials and applications
- Veterinary Equine Medical Research
- Periodontal Regeneration and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Pain Management
- Diagnosis and Treatment of Venous Diseases
Paracelsus Medical University
2016-2025
Austrian Cluster for Tissue Regeneration
2016-2025
University of Salzburg
2005-2010
Evangelisches Krankenhaus Kalk
1982
University of Vienna
1976-1977
The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were found close proximity to PCs. In Pdgfbret/ret mice, which have reduced PC numbers, oligodendrocyte progenitor cell (OPC) differentiation was delayed, although remyelination proceeded completion....
The origin of pericytes (PCs) has been controversially discussed and at least three different sources PCs are proposed: a neural crest, mesodermal, or bone marrow origin. In the present study we investigated potential crest ocular in transgenic Rosa26-YFP-Sox10-Cre crest-specific reporter mouse model developmental stages.The expresses yellow fluorescent protein (YFP) cells with an active Sox10 promoter was here used for cell fate studies Sox10-positive derived progeny cells. Detection YFP...
Rotator cuff tears are a common cause of shoulder pain and impairment. Subacromial glucocorticoid injections widely used for treatment epiphenomenons chronic impingement syndrome with the possible side effects tendon rupture impaired healing.Using qRT-PCR, western blot, immunoflourescence, measurement 3H-thymidine uptake we investigated crystalline triamcinolone acetonide (TAA) when added to culture medium isolated human rotator cells.After 2 weeks incubation, cells had lost their...
The extracellular matrix protein SPARC modulates load sensing in tendons and is critical for tissue maturation homeostasis.
Abstract Acute and chronic tendinopathies remain clinically challenging tendons are predisposed to degeneration or injury with age. Despite the high prevalence of tendon disease in elderly, our current understanding mechanisms underlying age-dependent deterioration function remains very limited. Here, we show that Secreted protein acidic rich cysteine (Sparc) expression significantly decreases healthy-aged mouse Achilles tendons. Loss Sparc results collagen fibrillogenesis defects Sparc−/−...
Tendon disorders frequently occur and recent evidence has clearly implicated the presence of immune cells inflammatory events during early tendinopathy. However, origin properties these remain poorly defined. Therefore, aim this study was to determine in healthy rodent human tendon tissue fulfilling macrophage-like functions. Using various transgenic reporter mouse models, we demonstrate resident dense matrix core expressing fractalkine (Fkn) receptor CX3CR1 its cognate ligand CX3CL1/Fkn....
Background/Aims: Effective wound-healing generally requires efficient re-vascularization after injury, ensuring sufficient supply with oxygen, nutrients, and various cell populations. While this applies to most tissues, tendons are mostly avascular in nature harbor relatively few cells, probably contributing their poor regenerative capacity. Considering the minimal vascularization of healthy tendons, we hypothesize that controlling angiogenesis early tendon healing is beneficial for repair...
Chronic and acute tendinopathies are difficult to treat tendon healing is generally a very slow incomplete process our general understanding of biology regeneration lags behind that muscle or bone. Although still largely unexplored, several studies suggest positive effect nutritional interventions on health repair. With this study, we aim reveal effects high-glucose diet neoformation in non-diabetic rat model Achilles tenotomy. After surgery animals received either control for 2 4 weeks,...
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) that leads to severe neurological deficits. Due their immunomodulatory and neuroprotective activities ability promote generation oligodendrocytes, mesenchymal stem cells (MSCs) are currently being developed for autologous cell therapy in MS. As aging reduces regenerative capacity all tissues, it relevance investigate whether MSCs retain pro-oligodendrogenic activity with increasing age. We demonstrate...
Abstract Purpose The repair of bony non-unions remains challenging and often requires graft material due to limited availability autologous bone. aim this study was investigate the potency a stand-alone pedicled periosteal flap (PF) versus ligated (PFx), an empty defect crossover group in terms newly formed bone 5 mm critical-sized rat femur diaphysis. Methods following 4 treatment groups were out total 36 male Sprague Dawley rats: Pedicled flap, (each n = 10) ( 6). A prospective randomized...
Neural stem and progenitor cells serve as a reservoir for new neurons in the adult brain throughout lifetime. One of critical steps determining net production is neural proliferation, which needs to be tightly controlled. Since inflammation has detrimental effects on neurogenesis 5-lipoxygenase/leukotriene pathway involved inflammatory processes, we investigated leukotrienes montelukast, small molecule inhibitor leukotriene receptors CysLT1R GPR17, cell proliferation. We demonstrate...
ABSTRACT MicroRNAs (miRNAs) have emerged as key regulators orchestrating a wide range of inflammatory and fibrotic diseases. However, the role miRNAs in degenerative shoulder joint disorders is poorly understood. The aim this explorative case‐control study was to identify pathology‐related, circulating patients with chronic rotator cuff tendinopathy tears (RCT). In 2017, 15 were prospectively enrolled assigned three groups based on diagnosed pathology: (i) no pathology, (ii) tendinopathy,...
Background: Toxicity of the local anesthetic bupivacaine (BV) has been a matter debate across medical fields. Numerous in vitro studies demonstrate considerable toxicity BV on various cell types. Purpose: This study addresses question how tendon tissue responds to vivo and vitro. Study Design: Controlled laboratory study. Methods: In cultured rat Achilles tendon–derived cells were performed with viability assays cleaved caspase 3 immunocytochemistry. Quantitative reverse...