A5088018260- Computational Drug Discovery Methods
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- Enzyme Catalysis and Immobilization
- Viral Infectious Diseases and Gene Expression in Insects
- MicroRNA in disease regulation
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Microbial Natural Products and Biosynthesis
- Cancer-related gene regulation
- Circular RNAs in diseases
- Monoclonal and Polyclonal Antibodies Research
- Click Chemistry and Applications
- Wnt/β-catenin signaling in development and cancer
- Cancer, Lipids, and Metabolism
- DNA and Nucleic Acid Chemistry
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Protein Kinase Regulation and GTPase Signaling
- Colorectal and Anal Carcinomas
- vaccines and immunoinformatics approaches
- Biochemical and Structural Characterization
- Influenza Virus Research Studies
- Pancreatic function and diabetes
- Colorectal Cancer Screening and Detection
Guilin Medical University
2013-2024
Zhejiang University
2008
Zhejiang Sci-Tech University
2008
// Rongzhong Jin 1, * , Jia Shen 2, Tiancheng Zhang 3, 4, Qiliang Liu 1 Caihua Liao Hailin Ma Sijing Li and Zhaoxia Yu 5 College of Biotechnology, Guilin Medical University, Guilin, China 2 Tumor Initiation Maintenance Program, Cancer Center, Sanford Burnham Prebys Discovery Institute, La Jolla, California, USA 3 Institute Reproduction Development, Fudan Shanghai, 4 National Population Family Planning Key Laboratory Contraceptive Drugs Devices, Shanghai Planned Parenthood Research (SIPPR),...
Avian influenza virus (H5N1) has caused serious infections in human beings. This the potential to emerge as a pandemic threat humans. Effective vaccines against H5N1 are needed. A recombinant Bombyx mori baculovirus, Bmg64HA, was constructed for expression of HA protein displaying on viral envelope surface. The accounted approximately 3% total proteins silkworm pupae infected with virus. Using series separation and purification methods, pure Bmgp64HA isolated from these bioreactors. Aluminum...
Small Nuclear Ribonucleoprotein Polypeptides B and B1 (SNRPB) have been linked to multiple human cancers. However, the mechanism of SNRPB in hepatocellular carcinoma (HCC) whether has a synergistic effect with sorafenib treatment HCC remain unclear. In this study, bioinformatic analysis found that was an independent prognostic factor for exerted critical on progression HCC. immune checkpoints, cell cycle, oxidative stress ferroptosis Single sequencing subset high expression SNRPB, accounted...
Abstract Background The competitive endogenous RNA (ceRNA) hypothesis is a novel effective theory that can enable us to deeply understand the mechanisms of comprehensive diseases. Methods In this study, we first downloaded RNAseq data and microRNA (miRNA) seq breast cancer from Cancer Genome Atlas further explored regulation ceRNA network in using bioinformatics tools. Results results revealed five miRNAs, including hsa‐miR‐10b, hsa‐miR‐21, hsa‐miR‐183, hsa‐miR‐1258, hsa‐miR‐3200 formed core...
Many important protein interactions related to cell signaling networks and post-translational modification events are mediated by the binding of a globular domain in one short peptide stretch another. In current study, we describe structure-level protocol realize quantitative prediction weak affinity such interactions. This method uses crystal structure CAL PDZ complexed with CFTR C-terminus mimic as template construct other congeneric domain-peptide complex models. Subsequently, independent...
Penicillin G amidase (PGA) is one of the most recognised biocatalysts because its critical application in antibiotic industry. Herein, additive effects involved transesterification catalysed by PGA are explored detail using a combination experimental analysis and theoretical modelling. The ability experimentally determined with 17 N-containing compounds as additives, and, on this basis, series quantitative structure–activity relationship (QSAR) models developed from various physicochemical...
Abstract The incidence of rectal cancer is increasing year by year. And most patients have been diagnosed in the advanced stages largely because special anatomical location rectum, resulting uneasy diagnosis its early stage. combination radiotherapy and chemotherapy widely accepted as effective treatment to cancer, significantly reduce local recurrence rate improve long-term survival, but occurrence resistance strikingly weaken responding treatment. So finding reasons or factors leading...