A5101987994- Bioactive Natural Diterpenoids Research
- Plant-based Medicinal Research
- RNA modifications and cancer
- Analytical Chemistry and Chromatography
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Corneal Surgery and Treatments
- Microfluidic and Capillary Electrophoresis Applications
- Alcohol Consumption and Health Effects
- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- Innovative Microfluidic and Catalytic Techniques Innovation
- Pharmacogenetics and Drug Metabolism
- Cholinesterase and Neurodegenerative Diseases
- Eicosanoids and Hypertension Pharmacology
- Cancer Treatment and Pharmacology
- Analytical Methods in Pharmaceuticals
- Glaucoma and retinal disorders
- Cell death mechanisms and regulation
- Diet, Metabolism, and Disease
- Receptor Mechanisms and Signaling
- Cancer-related molecular mechanisms research
- Neuropeptides and Animal Physiology
- Phytochemistry and Bioactive Compounds
Henan Provincial People's Hospital
2014-2023
Zhengzhou University
2014-2023
Zhengzhou People's Hospital
2014-2015
Sorafenib (SRB), a multikinase inhibitor, is effective in reducing experimental corneal neovascularization (CNV) after oral administration; however, its therapeutic use ocular surface disorders restricted due to poor solubility and limited bioavailability. This study aimed develop optimize SRB-loaded nanostructured lipid carriers (SRB-NLCs) for topical delivery by central composite design response methodology (CCD-RSM). It was spherical uniform morphology with an average particle size of...
Glaucoma, characterized with progressive degeneration of retinal ganglion cells (RGCs), is the second frequently leading cause sight loss in word after cataract. Baicalin plays a protective role age-related macular degeneration, retinopathy prematurity, branch vein occlusion, and ischemia-induced neurodegeneration retina. The present study aimed to investigate baicalin glaucoma. RGCs were stimulated N-methyl-D-aspartate (NMDA) mimic vitro model A mouse glaucoma induced by chronic elevated...
1. Polymorphisms of cytochrome P450 2C19 (CYP2C19) is an important factor contributing to variability voriconazole pharmacokinetics. CYP3A4, CYP3A5, CYP2C9 and non-genetic factors such as age, gender, body mass index (BMI), transaminase levels, concomitant medications might also affect initial steady serum trough concentration (VICmin) in haematological patients, but the effects were not clear. 2. Eighteen single-nucleotide polymorphisms CYP2C19, genotyped. Patients stratified into two...
// Yong-Cheng Ma 1, * , Yu Ke 2, Xiaolin Zi 3, 4, 5 Fei Zhao 1 Lin Yuan Ying-Li Zhu Xia-Xia Fan Ning-Min Qiao-Yan Li Yu-Hua Qin Hong-Min Liu 2 Clinical Pharmacology Laboratory, Zhengzhou University People's Hospital, Zhengzhou, Henan, China School of Pharmaceutical Sciences and Collaborative Innovation Center New Drug Research Safety Evaluation, University, 3 Department Urology, California, Irvine, USA 4 Pharmacology, Chao Family Comprehensive Cancer Center, These authors contributed equally...
Mitochondrial tRNA (Mt-tRNA) variants have been found to be involved in the carcinogenesis of breast cancer. These tRNAs, which played critical roles mitochondrial protein synthesis, were important regulators tumorigenesis. Distinguishing polymorphisms or mutations mt-tRNA genes was still puzzling for clinicians and geneticists when confronted with In this study, we performed a detailed analysis recently reported further discussed relationship between these
Background: Corneal neovascularization (CNV) is a pathological condition that can disrupt corneal transparency, thus harming visual acuity. However, there no effective drug to treat CNV. Sunitinib (STB), small-molecule multiple receptor tyrosine kinase inhibitor, was shown have an effect on The purpose of this study develop STB microemulsion (STB-ME) eye drop inhibit CNV by topical application. Methods: We successfully prepared STB-ME the phase inversion emulsification method, and...
Breast cancer is the most common form of among women globally, and chemoresistance a major challenge to disease treatment that associated with poor prognosis. This study was formulated identify reliable prognostic biosignature capable predicting survival patients chemoresistant breast (CRBC) evaluating tumor immune microenvironment. Through series protein-protein interaction weighted correlation network analyses, genes were significantly identified. Moreover, univariate Cox regression...
Itaconic acid is an excellent hydrophilic monomer owing to the dicarboxylic group possessing strong polarity. This study reports on preparation of a new organic-polymer monolithic column poly(itaconic acid-co-3-(acryloyloxy)-2-hydroxypropyl methacrylate) (poly(IA-co-AHM)) featuring chromatography ability and its application in pharmaceutical analysis. The was successfully synthesized by using itaconic cross-linker AHM through situ copolymerization method. Optical microscopy, scanning...
Recently, many researchers have reported that the genetic polymorphisms of CYP2C19 may account for interpatient variability clinical course in cancers including primary liver cancer (PLC). Besides CYP2C19, hepatitis viruses (HV, HAV, HBV, HCV, HDV, HEV, especially HBV and/or HCV) also PLC. This research covered above two factors and divided patients with PLC into groups (one group infection another without any HV infection) to find out whether different effects progressing patients. Eight...
To study the effects of Jaridonin, a novel diterpenoid from isodon rubescens, on cell cycle human gastric cancer cells and its molecular mechanism action.Flow cytometry was used to analyze distribution expression ataxia telangiectasia mutated kinase (ATM) after Jaridonin treatment. Western blot performed detect cycle-related proteins.The results flow showed that percentages MGC-803 in G(2)/M phase at 6 hours 0, 10, 20 μmol/L Jaridonin-treatment were (10.8±2.2)%, (18.2±2.5)%, (27.3±3.2)%,...
Itaconic acid is an excellent hydrophilic monomer owing to the dicarboxylic group possessing strong polarity. This study reports on preparation of a new organic polymer monolithic column poly(itaconic acid-co-3-(acryloyloxy)-2-hydroxypropyl methacrylate) (poly(IA-co-AHM)) featuring chromatography ability, and its application in pharmaceutical analysis. The was successfully synthesized using itaconic cross-linker AHM through in-situ copolymerization method. optical microscopy, SEM, FT-IR were...
Objective: To investigate the effects and underlying mechanism of DS2, a newly synthetic analog natural ent-kaurane diterpenoid, on proliferation migration capabilities human gastric cancer cells. Methods: MTT assay, colony formation assay flow cytometry were used to measure DS2 growth, apoptosis cell cycle several lines. The function in was further detected by wound healing transwell assays. expression related proteins determined western blot. Results: inhibited growth MGC-803, SGC-7901...