A5017387811- Pregnancy and preeclampsia studies
- Insect Resistance and Genetics
- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Cancer-related molecular mechanisms research
- Preterm Birth and Chorioamnionitis
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Circadian rhythm and melatonin
- Lipid metabolism and biosynthesis
- Cancer, Lipids, and Metabolism
- Malaria Research and Control
- Acute Kidney Injury Research
- Gout, Hyperuricemia, Uric Acid
- Mechanical Circulatory Support Devices
- Reproductive tract infections research
- Gastroesophageal reflux and treatments
- Genetic and phenotypic traits in livestock
- Blood donation and transfusion practices
- Sepsis Diagnosis and Treatment
- Organ Donation and Transplantation
- SARS-CoV-2 and COVID-19 Research
- Cancer, Hypoxia, and Metabolism
- Neonatal Health and Biochemistry
- Meat and Animal Product Quality
Michigan State University
2011-2025
Zhengzhou University
2023
Anhui Agricultural University
2023
Southeast University
2023
Hangzhou First People's Hospital
2022
Mianyang Normal University
2021
Central China Normal University
2015
Michigan United
2013
Taixing People's Hospital
2011
Shandong Normal University
2009
Wolbachia are maternally transmitted symbiotic bacteria that can spread within insect populations because of their unique ability to manipulate host reproduction. When introduced nonnative mosquito hosts, induce resistance a number human pathogens, including dengue virus (DENV), Plasmodium , and filarial nematodes, but the molecular mechanism involved is unclear. In this study, we have deciphered how infection affects Aedes aegypti in inducing DENV. The microarray assay indicates transcripts...
Wolbachia is a maternally transmitted symbiotic bacterium of insects that has been proposed as potential agent for the control insect-transmitted diseases. One major limitations preventing development malaria inability to establish inherited infections in anopheline mosquitoes. Here, we report establishment stable infection an important vector, Anopheles stephensi. In A. stephensi, strain wAlbB displays both perfect maternal transmission and ability induce high levels cytoplasmic...
Wolbachia is a maternally transmitted endosymbiotic bacterium that estimated to infect up 65% of insect species. The ability both induce pathogen interference and spread into mosquito vector populations makes it possible develop as biological control agent for vector-borne disease control. Although induces resistance dengue virus (DENV), filarial worms, Plasmodium in mosquitoes, species like Aedes polynesiensis albopictus, which carry native infections, are able transmit filariasis. In...
This study aimed to investigate the impacts of straw and biochar on greenhouse gas (GHG) emissions grain yield in a double rice cropping system under optimal N fertilizer reduction. Conventional fertilization (CF) was used as control group, treatments included 15% less nitrogen (OF), together with (S) or (B) applied different conditions, namely CF + S, B, OF B. The effects soil CH4 N2O were studied, changes physicochemical properties analyzed. results showed that relative CF, S increased...
Abstract Aberrant expression of miRNAs in pancreatic islets is closely related to the development type 1 diabetes (T1D). The aim this study was identify key dysregulated during T1D progression and develop a theranostic approach modify their using an MRI-based nanodrug consisting iron oxide nanoparticles conjugated miRNA-targeting oligonucleotides mouse model T1D. Isolated were derived from NOD mice three distinct age groups (3, 8 18-week-old). Total RNA collected cultured purified global...
Dysbiosis of the lower reproductive tract (LRT) in mares may play a role clinical diseases, including endometritis and placentitis. Metagenomic/metagenetic analysis bacterial DNA can identify organisms that are not readily cultured and, thus, go undetected. In this study, we tested following hypotheses: (1) clitoris estrual harbors unique resident microbiome, (2) topical Lactobacillus genus complex (LGC)-containing probiotic will alter equine clitoral (3) early pregnancy rates LGC...
This study aims to clarify relationships of maternal psychiatric conditions and selective serotonin reuptake inhibitor (SSRI) use during preconception pregnancy with risk neurodevelopmental disorders in offspring.We used data from the Study Explore Early Development, a multisite case-control conducted United States among children born between 2003 2011. Final group classifications autism spectrum disorder (ASD) (n = 1367), developmental delays or (DDs) 1750), general population controls...
The accumulation of neutral lipids in intracellular lipid droplets has been associated with the formation and progression many cancers, including prostate cancer (PCa). Alpha-beta Hydrolase Domain Containing 5 (ABHD5) is a key regulator that recently identified as tumor suppressor colorectal cancer, yet its potential role PCa not investigated. Through mining publicly accessible gene expression datasets, we found ABHD5 markedly decreased metastatic castration-resistant (mCRPC) samples. We...
Pre-eclampsia (PE) is a hypertensive condition that occurs during pregnancy and complicates up to 4% of pregnancies. PE exhibits several circadian-related characteristics, the placenta possesses functioning molecular clock. We examined associations 17 core circadian gene transcripts in with vs. non-PE (a mixture pregnant women term, preterm, small-for-gestational-age, or chorioamnionitis) using two independent expression datasets: GSE75010-157 (80 77 non-PE) GSE75010-173 (77 96 non-PE)....
Abstract Non-alcoholic fatty liver disease is associated with an irregular serine metabolism. Serine hydroxymethyltransferase 2 (SHMT2) a enzyme that breaks down into glycine and one-carbon (1C) units critical for methylation reactions overall health. However, the contribution of SHMT2 to hepatic 1C homeostasis biological functions has yet be defined in genetically modified animal models. We created mouse strain targeted knockout hepatocytes investigate this. The absence increased levels...
Multiple organ dysfunction syndrome (MODS) occurs in the setting of a variety pathologies including infection and trauma. Some patients decompensate require Veno-Arterial extra corporeal membrane oxygenation (ECMO) as palliating manoeuvre for recovery cardiopulmonary function. The molecular mechanisms driving progression from MODS to collapse remain incompletely understood, no biomarkers have been defined identify those at highest risk requiring ECMO support.Whole blood RNA-seq profiling was...
ABHD5 is an essential coactivator of ATGL, the rate-limiting triglyceride (TG) lipase in many cell types. Importantly, also functions as a tumor suppressor, and mRNA expression levels correlate with patient survival for several cancers. Nevertheless, mechanisms involved ABHD5-dependent suppression are not known. We found that overexpression induces cycle arrest at G1 phase causes growth retardation panel prostate cancer cells. Transcriptomic profiling biochemical analysis revealed genetic or...
Objective: Studies of maternal serum uric acid (UA) in pregnancy focus primarily on high levels UA, however, both low and UA can be markers oxidative stress, a biological state potentially linked to fetal growth. We therefore aimed test whether during are associated with atypical growth (unusually small or large) measured as birthweight (BW) for gestational age.Methods: The Pregnancy Outcomes Community Health Study enrolled 3019 pregnant women between their 16th–27th week from 52 clinics...
Long non-coding RNAs (lncRNAs) have a much higher cell- and/or tissue-specificity compared to mRNAs in most cases, making them excellent candidates for therapeutic applications reduce off-target effects. Placental long been investigated the pathogenesis of preeclampsia (often causing preterm birth (PTB)), but less is known about their role birth. Preterm occurs 11% pregnancies and common cause death among infants world. We recently identified that genes drive circadian rhythms cells, termed...
Both genetic variants and maternal blood mRNA levels of EBF1 gene have been linked to sPTB. Animal human studies suggest that specific EBF1-based miRNAs are involved in various physiological pathophysiological processes. However, date, we did not find any reports or miRNA transcripts relation We therefore aimed examine whether early B cell factor 1 (EBF1) gene-based microRNA (miRNA) can be used for detecting risk spontaneous preterm birth (sPTB).We conducted a nested case-control study...
Detailed taxonomic descriptions with photos are presented for seven dark fruiting Caloplaca species found in China. albovariegata , C. atrosanguinea and diphyodes apparently new to Asia, bogilana variabilis China, conversa pulicarioides northern
Abstract Epidemiological studies suggest that men exhibit a higher mortality rate to COVID-19 than women, yet the underlying biology is largely unknown. Here, we seek delineate sex differences in expression of entry genes ACE2 and TMPRSS2 , host responses SARS-CoV-2, vitro steroid hormone treatment. Using over 220,000 human gene profiles covering wide range age, tissues, diseases, found male samples show levels especially older group (>60 years) kidney. Analysis 6,031 patients at Mount...