A5088067766- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- Airway Management and Intubation Techniques
- CRISPR and Genetic Engineering
- Monoclonal and Polyclonal Antibodies Research
- Infection Control and Ventilation
- Medical Imaging Techniques and Applications
- vaccines and immunoinformatics approaches
- Occupational and environmental lung diseases
- Innovation and Socioeconomic Development
- Pericarditis and Cardiac Tamponade
- Pleural and Pulmonary Diseases
- Foreign Body Medical Cases
- Sphingolipid Metabolism and Signaling
- Adenosine and Purinergic Signaling
- Phenothiazines and Benzothiazines Synthesis and Activities
- Lipid Membrane Structure and Behavior
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Lysosomal Storage Disorders Research
- Nosocomial Infections in ICU
- Genetics, Aging, and Longevity in Model Organisms
- Atomic and Subatomic Physics Research
Shenzhen Third People’s Hospital
2011-2024
Southern University of Science and Technology
2020-2024
National Clinical Research
2024
Shanghai Clinical Research Center
2023
University of South China
2019
Shenzhen University
2018
Mycobacterium tuberculosis (Mtb) infection, including active (TB) and latent Mtb infection (LTBI), leads to diverse outcomes owing different host immune responses. However, the mechanisms that govern progression from LTBI TB remain poorly defined in humans. Here, we profiled lung cell populations within bronchoalveolar lavage fluid (BALF) patients with or using single-cell RNA sequencing (scRNA-seq). We found substantially changed compartments BALF, especially for three subsets of...
Characterization of the lung microbiota could lead to a better understanding pathogenesis pulmonary TB. Here, we applied metagenomic shotgun sequencing instead 16S rRNA method characterize using BALF samples sputum.
Abstract Tissue-resident memory T cells (TRMs) have a key role in mediating the host defense against tuberculosis (TB) mice, but their human counterparts not been well characterized. In this article, we recruited patients with TB and determined TRM frequency, trafficking, activation marker expression, cytokine production by flow or mass cytometry at different infection sites, including peripheral blood, pleural fluid, bronchoalveolar lavage lung. We found high frequency of TRMs all sites...
Bedaquiline (BDQ), a new antitubercular agent, has been used to treat drug-resistant tuberculosis (TB). Although mutations in atpE , rv0678 and pepQ confer major resistance BDQ, the mechanisms of BDQ vitro clinical settings have not fully elucidated. We selected BDQ-resistant mutants from 7H10 agar plates containing 0.5 mg/L (the critical concentration) identified associated with through whole genome sequencing Sanger sequencing. A total 1,025 were resistant BDQ. randomly 168 for further...
Coinfection of human immunodeficiency virus type 1 (HIV-1) is the most significant risk factor for tuberculosis (TB). The immune responses lung are essential to restrict growth Mycobacterium and avoid emergence disease. Nevertheless, there still limited knowledge about local response in people with HIV-1-TB coinfection.
Background Biomarker-based tests for diagnosing TB currently rely on detecting Mycobacterium tuberculosis (Mtb) antigen-specific cellular responses. While this approach can detect Mtb infection, it is not efficient in TB, especially patients who lack aetiological evidence of the disease. Methods We prospectively enrolled three cohorts our study a total 630 subjects, including 160 individuals to screen protein biomarkers 368 establish and test predictive model 102 biomarker validation. Whole...
Abstract Cone‐beam computed tomography (CBCT) system can provide real‐time 3D images and fluoroscopy of the region interest during operation. Some systems even offer augmented puncture guidance. The use CBCT for interventional pulmonary procedures has grown significantly in recent years, numerous clinical studies have confirmed technology's efficacy safety diagnosis, localization, treatment nodules. In order to optimize standardize technical specifications guide its application practice,...
The diagnosis of active pulmonary tuberculosis (TB) remains a challenge in clinic, especially for sputum negative TB. Bronchoalveolar lavage fluid (BALF) has higher sensitivity than detection Mycobacterium (Mtb). However, bronchoscopy is invasive and costly, not suitable all patients. In order to make TB patients get more benefit from BALF diagnosis, we explore which indicator might be used optimize the choice bronchoscopy. A total 1539 sputum-smear-negative suspects who underwent were...
Tuberculosis (TB) remains a major public health concern on global scale, especially in developing nations. So far, no formal guidelines are available for the diagnosis and treatment of tuberculosis pleurisy. The TB is worsened by immense difficulty differential determination pleural effusion (TPE) malignant (MPE). purpose this investigation to assess diagnostic efficiencies IFN-γ release assay (IGRA) widely-used biochemical parameters distinction analysis TPE MPE. A cohort 222 patients with...
Abstract Introduction LncRNA CCAT1 promotes inflammatory responses, which contribute to tuberculosis. Therefore, may participate in we analyzed the involvement of Methods Plasma samples were donated by a total 200 patients with newly developed tuberculosis (N‐TB), 102 recurrent (R‐TB), and healthy controls on day admission. also collected from N‐TB R‐TB every month after initiation treatment for 6 months. expression these was detected quantitative reverse transcription polymerase chain...
Tuberculosis (TB) remains a major threat to human health, and TB diagnostic methods remain unsatisfactory. Nucleic acid amplification tests (NAATs) show higher sensitivity compared with culture for the diagnosis of pulmonary (PTB). However, NAATs are expensive cannot be easily implemented outside medical centers. To improve PTB diagnosis, we investigated predictive factors that might optimize NAAT utilization. A total 1263 patients suspected were enrolled evaluation. The sensitivity,...
Tuberculosis (TB), which is caused by the single pathogenic bacterium, Mycobacterium tuberculosis, among top 10 lethal diseases worldwide. This situation has been exacerbated increasing number of cases multidrug-resistant TB (MDR-TB) and extensively drug-resistant (XDR-TB). Histamine an organic nitrogenous compound that mediates a plethora cell processes via different receptors. The expression histamine receptor H1 (HRH1), one four receptors identified to date was previously reported be...
Myriocin is an inhibitor of
Abstract: More children are benefitting from the wide application of bronchoscopy as interventional therapy to complications with airway involvement. We present case an 11-year-old boy tracheobronchial tuberculosis complicated by severe obstruction in left main bronchus. Early endoscopic balloon dilation and cryoablation were adopted adjunct his anti-tuberculosis treatment had shown satisfying outcomes. Keywords: pediatric, tuberculosis, procedure, bronchoscopy,
Mycobacterium tuberculosis (Mtb), the pathogenic agent of tuberculosis, remains a primary inducement morbidity and mortality globally. Mtb have evolved mechanisms to recognize diverse signals, such as acidic pH within phagolysosomes therefore reprogram multiple physiological metabolic processes adapt intracellular survival. Moreover, lysine malonylation has been suggested participate in regulation enzymes carbon metabolism. However, its association with associated metabolism adaptation...
The treatment of multidrug-resistant tuberculosis (MDR-TB) relies heavily on optimal chemotherapy, but interventional therapies can be adopted as adjuvant to speed up illness control and increase the cure rate. We present a case 31-year-old MDR-TB male patient with massive pulmonary cavity in right lower lung cured by chemotherapy catheter inserted treatment. This illustrated that early therapy increases success rate for patients empyema without need major invasive surgery consequently...
Abstract Background: Tuberculosis (TB) remains one of the primary threatening human health and its diagnosis unsatisfactory in clinic. Nucleic acid amplification tests (NAAT) showed higher sensitivity than culture for pulmonary TB (PTB). However, NAAT are expensive not easily deployable at peripheral level. To improve PTB diagnosis, predictive factors that might be utilized to give optimized choice were investigated. Methods: A total 1263 suspects enrolled evaluation. The sensitivity,...