A5103038036- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- Tuberculosis Research and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Viral Infections and Vectors
- Viral gastroenteritis research and epidemiology
- Immune responses and vaccinations
- Immune Cell Function and Interaction
- Bacterial Infections and Vaccines
- interferon and immune responses
- Antibiotics Pharmacokinetics and Efficacy
- Infectious Encephalopathies and Encephalitis
- Inflammation biomarkers and pathways
- Antibiotic Use and Resistance
- COVID-19 Impact on Reproduction
- Virology and Viral Diseases
- Animal Virus Infections Studies
- Tracheal and airway disorders
- Neuroinflammation and Neurodegeneration Mechanisms
Chongqing Medical University
2015-2024
Children's Hospital of Chongqing Medical University
2015-2024
China International Science and Technology Cooperation
2014-2024
China Guangzhou Analysis and Testing Center
2024
Respiratory syncytial virus (RSV) is the most important cause of lower respiratory tract infection in young children and leading infant hospitalization worldwide. Uncontrolled response to RSV mediated by a toll-like receptor (TLR)-mediated immune response. Resveratrol possesses anti-RSV activity an inhibitor TRIF/TBK1/IRF-3 complex. We hypothesize that resveratrol inhibits TRIF-dependent pathway through upregulation SARM post-RSV infection. BALB/c mice were infected with injected 1 h...
<abstract abstract-type="Abstract"> <sec> <b>Introduction</b> A retrospective study based on sentinel surveillance was conducted in 10 provincial-level administrative divisions (PLADs) China to enhance the understanding of epidemiological characteristics human parainfluenza viruses (HPIVs). </sec><sec> <b>Methods</b> From January 2019 June 2023, respiratory specimens were collected from individuals with acute infections (ARIs) and screened for four HPIVs serotypes other common using...
Background: To clarify the characteristic and duration of positive nucleic acid in children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including asymptomatic children. Methods: A total 32 confirmed SARS-CoV-2 infection between January 24 February 12, 2020 from four provinces western China were enrolled this study followed up until discharge quarantine 14 days later. Results: Eleven (34%) asymptomatic, among whom six had normal computed tomographic (CT) scan...
Glucocorticoid resistance is a challenging problem in clinical practice. Increasing glucocorticoid sensitivity and reducing are important the management of certain diseases. In steroid-resistant airway inflammatory diseases, receptor (GR) expression reduced, impaired GR nuclear translocation closely related to resistance. Histone deacetylase SIRT1 regulates steroid hormone activity interacts with androgen GR. some glucocorticoid-resistant reduced. Here, we review recent advances role...
IL-17A is a pleiotropic cytokine and intimately associated with asthma, but its role in respiratory syncytial virus (RSV) infection conflicting the literature. Children hospitalized department RSV during pandemic season of 2018-2020 were included. Nasopharyngeal aspirates collected for pathogen cytokines determination. In murine model, intranasal administrations performed wild-type IL-17A-/- mice. Leukocytes bronchoalveolar lavage fluid (BALF), lung histopathology, airway hyperresponsiveness...
Respiratory syncytial virus (RSV) is one of the most frequently observed pathogens during infancy and childhood. However, corresponding pathogenesis has not been determined to date. We previously demonstrated that IFN-γ plays an important role in RSV pathogenesis, SARM-TRIF-signaling pathway could regulate production IFN-γ. This study investigate whether T cells or innate immune are predominant producers IFN-γ, further explore other culprits addition condition infection.Normal BALB/c mice...
The type 2 immune response, induced by infection of respiratory syncytial virus (RSV), has been linked to asthma development, but it remains unclear how the response is initiated. Here, we reported that high-mobility group box-1 (HMGB1) protein promotes in later stage RSV infection. In mice, found cytokines were elevated stages, which strongly diminished after administration anti-HMGB1 antibodies. Further investigation revealed HMGB1 expression was localized CC10+ club cells lung. clinic,...
Background Tuberculous meningitis (TBM) is a devastating form of tuberculosis (TB) causing high mortality and disability. TBM arises due to immune dysregulation, but the underlying mechanisms are unclear. Methods We performed single-cell RNA sequencing on peripheral blood mononuclear cells (PBMCs) cerebrospinal fluid (CSF) isolated from children (n=6) with using 10 xGenomics platform. used unsupervised clustering cluster visualization based gene expression profiles, validated protein...
Despite their powerful antiinflammatory effect, glucocorticoids have shown no significant clinical benefit in respiratory syncytial virus (RSV)-induced bronchiolitis, the reason for which remains unclear. Upon glucocorticoid binding, cytoplasmic receptor (GR) translocates to nucleus with help of importin 13 (IPO13). Here, we report that RSV infection reduced GR nuclear translocation nasopharyngeal aspirates from RSV-infected infants, lungs infected mice, and A549 cells, coincided decreased...
To understand the epidemiological characteristics of human respiratory syncytial virus (HRSV) among acute infection (ARI) cases in 16 provinces China from 2009 to 2023.
Abstract Background To clarify the characteristic and duration of positive nucleic acid in children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including asymptomatic children. Methods A total 32 confirmed SARS-CoV-2 infection between January 24 February 12, 2020 from four provinces Western China were enrolled this study followed up until discharge quarantine 14 days later. Results Eleven (34%) asymptomatic, among whom six had normal computed tomographic (CT)...
Abstract Background RSV can lead to persistent airway inflammation and hyperresponsiveness (AHR), is intimately associated with childhood recurrent wheezing asthma, but the underlying mechanisms remain unclear. Lipopolysaccharide (LPS) also implicated in onset exacerbation of asthma. However, whether inhalation LPS boost induced by not clear. In this study, we utilized an LPS- RSV-superinfected mouse model explore pathogenesis. Methods Mice were infected on day 0 inoculated from 35 41,...
In the current study, we report on 4 children with confirmed SARS-CoV-2 infection, of which 3 them were asymptomatic. These patients had both pharyngeal swabs and anal testing during hospital or after discharge. All showed long-time positive viral RNA in stool specimens turned negative follow-up stage, especially asymptomatic children. The last for more than 54 days admission 30
Pediatric tuberculosis (TB) is one of the top ten causes death in children. Our study was to analyze influencing factors multidrug-resistant (MDR-TB) and validation whole-genome sequencing (WGS) used children with drug-resistant TB (DR-TB).All Mycobacterium (Mtb) strains were isolated from patients aged below 18 years old Children's Hospital Chongqing Medical University, China. A total 208 Mtb isolates tested for eight anti-TB drugs phenotypic drug susceptibility test (DST) genetic...
Tuberculosis (TB), which is caused by the single pathogenic bacterium, Mycobacterium tuberculosis, among top 10 lethal diseases worldwide. This situation has been exacerbated increasing number of cases multidrug-resistant TB (MDR-TB) and extensively drug-resistant (XDR-TB). Histamine an organic nitrogenous compound that mediates a plethora cell processes via different receptors. The expression histamine receptor H1 (HRH1), one four receptors identified to date was previously reported be...
人冠状病毒最早于20世纪60年代被分离，是儿童呼吸道感染的重要病原。已发现7种可导致人类疾病的冠状病毒，其中严重急性呼吸综合征相关冠状病毒、中东呼吸综合征相关冠状病毒及2019新型冠状病毒传染性及致病性强，严重威胁人类健康及全球经济。本综述重点阐述以上3种高致病性人冠状病毒在患儿中的特点，以期为未来疫情的监测和防控提供参考。
<title>Abstract</title> <bold>Objective：</bold>By analyzing the epidemiological data of 876 children with Pulmonary Tuberculosis (PTB) and risk factors severe case.<bold> </bold> <bold>Methods: </bold>Retrospective analyzed related clinical hospitalized who were first diagnosed or clinically PTB at a Children's Hospital Chongqing China from January 2016 to December 2020. <bold>Results:</bold> There total 454 (51.83% ) cases combined extrapulmonary tuberculosis. Hospitalization time ranged 1...