A5083457739- Molecular Sensors and Ion Detection
- Sulfur Compounds in Biology
- Synthesis and biological activity
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Computational Drug Discovery Methods
- Click Chemistry and Applications
- Nitric Oxide and Endothelin Effects
- Microbial Natural Products and Biosynthesis
- Cancer therapeutics and mechanisms
- Electrochemical sensors and biosensors
- RNA Interference and Gene Delivery
- Advanced Chemical Sensor Technologies
- Synthesis and Biological Evaluation
- Melanoma and MAPK Pathways
- Amino Acid Enzymes and Metabolism
- Crystallization and Solubility Studies
- Antibiotic Resistance in Bacteria
- Carbon and Quantum Dots Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Analytical Chemistry and Sensors
- NMR spectroscopy and applications
- HER2/EGFR in Cancer Research
Jinhua Academy of Agricultural Sciences
2021-2025
Nanjing University
2014-2024
State Key Laboratory of Pharmaceutical Biotechnology
2012-2022
Pharmaceutical Biotechnology (Czechia)
2014-2022
Zhengzhou Children's Hospital
2019-2021
Zhengzhou University
2019-2021
China Pharmaceutical University
2012-2020
Institute of Chemistry
2016-2020
Purdue University West Lafayette
2019
State Council of the People's Republic of China
2016
The abnormal angiogenesis and insufficient oxygen supply in solid tumors lead to intratumoral hypoxia, which severely limits the efficacy of traditional photodynamic therapy (PDT). Here, a multifunctional nanoplatform (ZDZP@PP) based on zeolitic imidazolate framework-67 (ZIF-67) core as hydrogen peroxide catalyst, framework-8 (ZIF-8) shell with pH-responsive property, polydopamine–poly(ethylene glycol) (PDA–PEG) layer for improving biocompatibility is fabricated not only relieving tumor...
Responsive nanocarriers with biocompatibility and precise drug releasing capability have emerged as a prospective candidate for anticancer treatment. However, the challenges imposed by complicated preparation process limited loading capacities seriously impeded development of novel multifunctional delivery systems. Here, we developed dual-responsive nanocarrier based on nanoscale ZIF-8 core an organosilica shell containing disulfide bridges in its frameworks through facile efficient...
Based on OR logic gate, we proposed a smart near-infrared (NIR) fluorescent probe, named VPCPP, for simultaneously monitoring local microviscosity, micropolarity, and carboxylesterases (CEs) in living cells through blue red channels. This probe was capable of distinguishing cancer from normal had good potential identifying liver cell lines. Furthermore, the fluctuations three analytes interest different status successfully explored. Particularly, facilitated with high-content analysis (HCA)...
TPABF-HS, accompanied by an HSA-binding-based approach for amplifying the fluorescence signal, has achieved a wide linear range of 0–1000 μM.
Lipid metabolism diseases have become a tremendous risk worldwide, along with the development of productivity and particular attention to public health. It has been an urgent necessity exploit reliable imaging strategies for lipids thus monitor fatty liver diseases. Herein, by converting NIR-I signal NIR-II IR1061 monitoring lipid, in vivo disease was promoted on contrast visual effect. The main advantages promotion this work included long emission wavelength, rapid response, high...
In this work, a photoacoustic (PA) probe, HDS-GGT, was developed for the in vivo imaging of cardiovascular diseases by monitoring γ-glutamyl transferase (GGT) dynamics. HDS-GGT exhibited stable PA signal with auxiliary absorbance and NIRF variation after trigger GGT. all three modalities absorbance, NIRF, PA, could quantitatively reflect GGT level. modality, indicated practical advantages including high sensitivity, stability, specificity. living oxidized low-density lipoprotein-induced...
Copper ions, implicated in processes such as oxidative stress and inflammation, are believed to play a crucial role cardiovascular disease, prevalent deadly disease. Despite this, current diagnostic methods fail detect early stage disease or track copper ion accumulation, limiting our understanding of the disease's progression. Therefore, development noninvasive techniques image ions is urgently needed enhance precision therapeutic strategies. In this study, we report successful synthesis...
Realizing the early diagnosis of acute liver injury has become a hotspot in recent years. Since current indexes are not specific, developing novel probes with new recognition group remains necessity. In this work, we developed fluorescent probe, NNP, for detection ONOO− (ALI). The vitro evaluation NNP indicated advantages including high sensitivity (LOD = 0.13 μM), rapid response (<25 s), naked-eye (red to yellow), and stability under various pH (4–10) time (>48 h) conditions. Accordingly,...