A5101669162- Spectroscopy Techniques in Biomedical and Chemical Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Hepatitis B Virus Studies
- Advanced biosensing and bioanalysis techniques
- Cancer Risks and Factors
- Spectroscopy and Chemometric Analyses
- Analytical Chemistry and Sensors
- Breast Lesions and Carcinomas
- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Molecular Biology Techniques and Applications
- Gallbladder and Bile Duct Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Orthopedic Surgery and Rehabilitation
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Global Cancer Incidence and Screening
- Anesthesia and Sedative Agents
- Immune Cell Function and Interaction
- Anesthesia and Pain Management
- Cancer Mechanisms and Therapy
- AI in cancer detection
- Advanced Nanomaterials in Catalysis
- Elbow and Forearm Trauma Treatment
Second Hospital of Shandong University
2016-2025
Shandong Center for Disease Control and Prevention
2019-2025
Shandong University
2019-2025
Zhejiang Cancer Hospital
2020-2025
Centre for Addiction and Mental Health
2025
North China Electric Power University
2025
China Electric Power Research Institute
2025
University of Toronto
2025
Henan Academy of Sciences
2024
Shanghai University of Traditional Chinese Medicine
2015-2024
Breast cancer subtypes have important implications of treatment responses and clinical outcomes. Exosomes been considered as promising biomarkers for liquid biopsies, but the utility exosomes accurate diagnosis distinct breast is a grand challenge due to difficulty in uncovering subtle compositional difference complex settings. Herein, we report an artificial intelligent surface-enhanced Raman spectroscopy (SERS) strategy label-free spectroscopic analysis serum exosomes, allowing assessment...
Protein profiles of exosomes (EXOs) in clinical samples cancer patients have become a promising diagnostic and therapeutic biomarker. However, simultaneous quantitative analysis multiple exosomal proteins interest remains challenging. To address the unmet need, we develop paper-based surface-enhanced Raman spectroscopy (SERS)-vertical flow biosensor, named iREX (integrated spectroscopic EXO) for multiplexed profiling serum patients. Utilizing this are able to quantitatively profile MUC1,...
Ultrafast and computing resource-saving prediction of the far- near-field optical properties plasmonic nanoparticles inverse design their dimensions from far-field spectra can be realized using machine learning.
In vivo surface-enhanced Raman scattering (SERS) imaging allows non-invasive visualization of tumors for intraoperative guidance and clinical diagnostics. However, the in utility SERS is greatly hampered by strong optical autofluorescence background biological tissues lack highly active plasmonic nanostructures. Herein, we report a class porous nanostructures comprising cubic AuAg alloy nanoshell numerous nanopores. Such exhibit excellent near-infrared II properties tunable broad spectral...
Abstract Background Neoadjuvant chemotherapy (NAC) has become a standard treatment strategy for breast cancer (BC). However, owing to the high heterogeneity of these tumors, it is unclear which patient population most likely benefit from NAC. Multi-omics offer an improved approach uncovering genomic and transcriptomic changes before after NAC in BC identifying molecular features associated with sensitivity. Methods We performed whole-exome RNA sequencing on 233 samples (including matched...
Recent advances in animal modeling, imaging technology, and functional genomics have permitted precise molecular observations of the metastatic process. However, a comprehensive understanding premetastatic niche remains elusive, owing to limited tools that can map subtle differences mediators organ-specific microenvironments. Here, we report ability detect changes lung microenvironment, response primary breast tumors, using combination mouse models, Raman spectroscopy, multivariate analysis...
Exosomes (exos) widely existing in body fluids show great potential for noninvasive cancer diagnosis. Quantitative analysis of exos is traditionally performed by targeting specific exosomal surface proteins, but it often imprecise due to the common expression proteins and subtle differences between different subtypes. Herein, we report quantitative surface-enhanced Raman spectroscopy (SERS) serum through a combination paper-based lateral flow strip (LFS) biosensor with multivariate spectral...
Purpose: Raman spectroscopy was explored to diagnose normal, benign, and malignant human breast tissues based on principal component analysis (PCA) support vector machine‐recursive feature elimination (SVM‐RFE), SVM‐RFE results were compared with PCA. Methods: 1800 spectra acquired from fresh samples of (normal, fibroadenoma, adenosis, galactoma, invasive ductal carcinoma) 168 patients. After set up the PCA models, Mahalanobis distance, spectral residuals, sensitivity, specificity, Matthews...
Leveraging optimally engineered SERS tags and urea-based small-molecule inhibitor of PSMA, we report an ultrahigh binding affinity imaging nanoplex for castrate resistant prostate cancer demonstrate live single cell vibrational spectroscopic at ultralow concentrations.
The expression of human epidermal growth factor receptor-2 (HER2) has important implications for pathogenesis, progression, and therapeutic efficacy breast cancer. detection its variation during the treatment is crucial decision-making but remains a grand challenge, especially at cellular level. Here, we develop machine learning-driven surface-enhanced Raman spectroscopy (SERS)-integrated strategy label-free HER2. Specifically, our method allows extraction cell-rich spectral signatures...
Objective Gastric cancer (GC) ranks fifth in incidence and fourth for mortality worldwide. The response to immune checkpoint blockade (ICB) therapy GC is heterogeneous due tumour-intrinsic acquired immunotherapy resistance. We developed an immunophenotype-based subtyping of human based on cells infiltration develop a novel treatment option. Design A algorithm was reclassify into inflamed, excluded desert subtypes. Bioinformatics, mouse cell lines, syngeneic murine gastric tumour model, CTLA4...
Early prediction of the neoadjuvant therapy efficacy for HER2-positive breast cancer is crucial personalizing treatment and enhancing patient outcomes. Exosomes, which play a role in tumor development response, are emerging as potential biomarkers diagnosis prediction. Despite their promise, current exosome detection isolation methods cumbersome time-consuming often yield limited purity quantity. In this study, we employed Raman spectroscopy to analyze molecular changes exosomes from sera...
ABSTRACT TWIST1 is aberrantly expressed in ovarian cancer (OC). MFAP2 a downstream target of TWIST1, and we previously found facilitated OC development by activating FOXM1/β‐catenin. We planned to investigate the mechanisms OC. GEPIA (a database for gene expression analysis) UALCAN containing comprehensive transcriptome clinical patient data) investigated TWIST1's connection survival serous cystadenocarcinoma (OV). Human cells (A2780 CAOV3) were transfected with si‐TWIST1, oe‐TWIST1,...
Shell-isolated nanoparticle-enhanced Raman spectroscopy provides a powerful method for molecular examination of breast pathology enabling early detection cancer foci.
Raman spectroscopy has been widely used as an important clinical tool for real-time in vivo cancer diagnosis. information can be obtained from whole organisms and tissues, at the cellular level biomolecular level. The aim of this paper is to review newest developments field breast diagnosis treatment. distinguish malignant tissues noncancerous/normal assess tumor margins or sentinel lymph nodes during operation. At level, spectra monitor intracellular processes occurring blood circulation....