A5100682555- Animal Virus Infections Studies
- Virus-based gene therapy research
- Virology and Viral Diseases
- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Autophagy in Disease and Therapy
- Respiratory viral infections research
- interferon and immune responses
- Viral Infections and Vectors
- Viral Infections and Immunology Research
- Sesame and Sesamin Research
- Immunotherapy and Immune Responses
- Aquaculture disease management and microbiota
- Infection Control and Ventilation
- Mollusks and Parasites Studies
- Dendrimers and Hyperbranched Polymers
- Viral gastroenteritis research and epidemiology
- Traditional Chinese Medicine Analysis
- Hepatitis C virus research
- Hip and Femur Fractures
- Parkinson's Disease Mechanisms and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Immune responses and vaccinations
- Hemostasis and retained surgical items
- Parasite Biology and Host Interactions
Chinese Center For Disease Control and Prevention
2024
National Health and Family Planning Commission
2024
Beijing University of Agriculture
2018-2024
Southwest Medical University
2024
Affiliated Hospital of Southwest Medical University
2024
Xinjiang University
2021
Academy of Military Medical Sciences
2021
Beijing University of Chinese Medicine
2018-2020
China Agricultural University
2013-2020
Southwest University
2019
In 2012, an unprecedented large-scale outbreak of disease in pigs China caused great economic losses to the swine industry. Isolates from pseudorabies virus epidemics herds were characterized. Evidence confirmed that pathogenic was etiologic agent this epidemic.
Hydroxysafflor yellow A (HSYA) is a water-soluble component of the safflower (Carthamus tinctorius), and research has revealed that HSYA exhibits antitumor effects. In present study, effects on autophagy Hep-G2 liver cancer cell line, as well underlying mechanisms, were investigated. cells treated with viability was measured using an MTT assay. Western blotting immunofluorescence assays performed to determine expression light chain 3 II (LC3-II) p62, regulators Beclin 1 ERK1/2. Transmission...
As the first line of antiviral defense, type I interferon (IFN) binds IFN receptor 1 (IFNAR1) and IFNAR2 to activate Jak-STAT signal transduction pathway, producing IFN-stimulated genes (ISGs) control viral infection. The mechanisms by which human cytomegalovirus (HCMV) counteracts pathway are only partially defined. We show that miR-US33as-5p encoded HCMV is expressed in both lytic latent By analysis with RNA hybrid screening luciferase reporter assays, we identified IFNAR1 as a target...
IFIT1 (also known as ISG56) is a member of the interferon-inducible protein with tetratricopeptide repeats (IFITs) family. IFITs are strongly induced by type I interferon (IFN), double-stranded RNA and virus infection. Here, we investigated expression in human umbilical vein endothelial cells (HUVECs) bronchus epithelial (BEAS-2Bs) H9N2 inactivated viral particle at different time points. We also effect infection on IFN-α/β production, assessed whether hemagglutinin or neuraminidase...
To prove whether error catastrophe /lethal mutagenesis is the primary antiviral mechanism of action ribavirin against foot-and-mouth disease virus (FMDV). Ribavirin passage experiments were performed and supernatants <TEX>$Rp_1$</TEX> to <TEX>$Rp_5$</TEX> harvested. Morphological alterations as well levels viral RNAs, proteins, infectious particles in BHK-21 cells infected using control measured by microscope, real-time RT-PCR, western-blotting plaque assays, respectively. The mutation...
This study focuses on evaluating the therapeutic efficacy of cecropin AD, an antimicrobial peptide, against H9N2 avian influenza virus (AIV) in chickens. Given global impact AIV poultry health, identifying effective treatments is crucial. To assess we conducted vivo experiments involving 108 5-week-old chickens divided into control, infected, and various treatment groups based AD dosage levels (high, medium, low). The methodologies included hemagglutination (HA) tests for viral titers,...
Danqi pill (DQP) is a widely prescribed traditional Chinese medicine (TCM) in the treatment of cardiovascular diseases. The objective this study to systematically characterize altered gene expression pattern induced by myocardial ischemia (MI) rat model and investigate effects DQP on global expression. Global mRNA was measured. Differentially expressed genes among sham group, group were analyzed. ontology enrichment analysis pathway differentially carried out. We quantified 10,813 genes....
The PD-1/PD-L1 pathway is an inhibitory signaling that maintains the balance between immune response and immunotolerance, its overactivation in cancer viral infections inhibits T cell function. target cells of various viruses, microvascular endothelial (MECs) have been shown to be key regulatory points regulation virion diffusion vivo during infection with multiple influenza virus subtypes. Furthermore, avian (AIV) can induce immunosuppression by causing imbalances responses organ damage....
Background The H5 avian influenza viruses (AIVs) of clade 2.3.4.4 circulate in wild and domestic birds worldwide. In 2017, nine strains H5N6 AIVs were isolated from aquatic poultry Xinjiang, Northwest China. Objectives This study aimed to analyze the origin, reassortment, mutations AIV isolates. Methods oropharyngeal cloacal swabs poultry. Identification was accomplished by inoculating isolates into embryonated chicken eggs performing hemagglutination tests reverse transcription polymerase...
Fractures are a common and serious injury among children. While many studies have utilized clinical data, there is lack of large-scale community-based research in China.
As a consequence of the continued growth global division labour, labour that occurs inside value chain has evolved into practise is generally accepted in number multinational industries. However, due to sluggish state economy and rise trade protectionism last several years, international cooperation among states chains been hampered. Reviving throughout an urgent problem be addressed today's interconnected economy. If China's policies concentrate on researching reconstruction regional within...
Objective To evaluate the inhibitory effect of chidamide combined with curcumin on proliferation cutaneous T-cell lymphoma (CTCL) cell line Hut78, as well their promotive its apoptosis, and to explore therapeutic mechanisms in CTCL. Methods Some Hut78 cells were treated different concentrations (0.3, 0.6, 1.2, 2.4 μmol/L) 10 μmol/L alone or combination 1.2 for 24, 48 72 hours separately. MTS assay was conducted estimate viability at each time point. After selection concentrations,...
Objective To evaluate the effect of JY adjuvant, which is composed IL-2 and chitosan, on immune response for mucosal immunization with human papillomavirus types 16 18 L1 virus-like particles (HPV16+ VLP). Methods Mice were immunized three times HPV16+ VLP in presence or absence adjuvant by intramuscular intranasal routes, respectively. Subsequently, experiments undertaken to detect serum IgG antibody, neutralizing antibody respiratory tract washes sIgA titers cellular...
Objective To explore the 5-aminolevulinic acid (5-ALA) mediated photodynamic therapy(PDT) for proliferation and apoptosis of gastric cancer cell line MKN-45. Methods The human MKN-45 was cultured in vitro. The MTT method used to detect fixed lighting processing (laser radiation dose 25.00 J/cm2, 5-ALA photosensitizer concentrations were 0 mmol/L, 0.25 0.50 1.00 2.00 mmol/L), concentration treatment (5-ALA laser 6.25 12.50 50.00 100.00 J/cm2) rate, then 1 mmol/L selected control group,...