A5050912043- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Fibrosis and Remodeling
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Long-Term Effects of COVID-19
- Electron Spin Resonance Studies
- Traditional Chinese Medicine Analysis
- Cardiac electrophysiology and arrhythmias
- Cancer Treatment and Pharmacology
- Synthesis and Biological Evaluation
- Chemotherapy-induced organ toxicity mitigation
- Cancer-related cognitive impairment studies
- Autophagy in Disease and Therapy
- Signaling Pathways in Disease
- COVID-19 Clinical Research Studies
- Calcium signaling and nucleotide metabolism
- Cardiac Ischemia and Reperfusion
- Endoplasmic Reticulum Stress and Disease
- Adenosine and Purinergic Signaling
- Erythropoietin and Anemia Treatment
- Heart Rate Variability and Autonomic Control
- Heat shock proteins research
- Vitamin C and Antioxidants Research
- Mitochondrial Function and Pathology
- Plant-derived Lignans Synthesis and Bioactivity
Beijing University of Chinese Medicine
2019-2025
Anhui University of Traditional Chinese Medicine
2024-2025
Weatherford College
2020
Aim: Inflammation and fibrosis have been shown to be critical factors in heart failure (HF) progression. Calycosin (Cal) is the major active component of Astragalus mongholicus Bunge has reported therapeutic effects on cardiac dysfunction after myocardial infarction. However, whether Cal could ameliorate infarction (MI)-induced inflammation precise mechanisms remain uncertain. The aim this study explore role HF clarify underlying mechanisms. Methods: For vivo experiments, rats underwent left...
This study aimed to investigate the intrinsic mechanisms of Qishen granules (QSG) in treatment HF, and provide new evidence insights for its clinical application. Information on QSG ingredients was collected from Traditional Chinese medicine systems pharmacology (TCMSP), TCM@Taiwan, TCMID, Batman, input into SwissTargetPrediction identify compound targets. HF-related targets were detected Therapeutic Target Database (TTD), Disgenet-Gene, Drugbank database, Online Mendelian Inheritance Man...
Retinoid X receptor alpha (RXRα) is a nuclear transcription factor that extensively regulates energy metabolism in cardiovascular diseases. Identification of targeted RXRα drugs for heart failure (HF) therapy urgently needed. Neocryptotanshinone (NCTS) component derived from Salvia miltiorrhiza Bunge, the effect and mechanism which treating HF have not been reported. The goal this study was to explore pharmacological effects NCTS on protect against post-acute myocardial infarction (AMI) via...
Doxorubicin (DOX), the anthracycline chemotherapeutic agent, is widely used for treatment of various cancers. However, its clinical application compromised by dose-dependent and fatal cardiotoxicity. This study aimed at investigating cardioprotective effects Qishen granule (QSG) specific mechanism which QSG alleviates DOX-induced cardiotoxicity (DIC) providing an alternative DIC. We first evaluated in a DIC mouse model, obtained results showed that significantly protected against myocardial...
Background A worldwide outbreak of coronavirus disease (COVID-19), since 2019, has brought a disaster to people all over the world. Many researchers carried out clinical epidemiological studies on patients with COVID-19 previously, but risk factors for different levels severity are still unclear. Methods 562 laboratory-confirmed from 12 hospitals in China were included this retrospective study. Related information, therapies, and imaging data extracted electronic medical records compared...
Abstract Objective: Inflammation and fibrosis are strongly associated with each other. Glycine is present in various traditional Chinese medicines exhibits anti-inflammatory activity. However, the effects of glycine on myocardial (MF) rats infarction (MI) have not been reported. The purpose this study to investigate therapy MF comprehend its underlying mechanisms. Materials Methods: Left anterior descending artery ligation-induced MI Sprague Dawley was leveraged assess therapeutic Glycine....
BackgroundDoxorubicin (DOX) is widely used for the treatment of a variety cancers. However, its clinical application limited by dose-dependent cardiotoxicity. Recent findings demonstrated that autophagy inhibition and apoptosis cardiomyocytes induced oxidative stress dominate pathophysiology DOX-induced cardiotoxicity (DIC), however, there are no potential molecules targeting on these.PurposeThis study aimed to explore whether aucubin (AU) acting specific crosstalk between NRF2 HIPK2...
Background: Despite advancements in chronic heart failure (CHF) treatment, the effect often remains unsatisfactory and unstable. More effective therapies are needed. Qishen granules (QSG) a novel Chinese botanical drug treating CHF animal models, but clinical evidence inadequate. Objective: This study aims to evaluate effects of QSG on patients with CHF. Methods: We enrolled this 12-week, randomized, double-blind, placebo-controlled trial randomly assigned them (twice day, 6.8 g at once) or...
In this multicenter retrospective study, patients with COVID-19 in China were included and classified into two groups according to whether they complicated diabetes or not. Demographic symptoms laboratory data extracted from medical records. Univariable multivariable logistic regression methods used explore the risk factors.538 finally of whom 492 nondiabetes 46 diabetes. The median age was 47 years (IQR 35.0-56.0). And elderly more likely have dry cough, alanine aminotransferase, lactate...
Qishen granules (QSG) is a famous traditional Chinese Medicine (TCM) formula used to treat chronic heart failure (CHF). The objective of this protocol clarify the efficacy and safety QSG for treating CHF.Six databases will be electronically searched up November 1, 2020 randomized controlled trials (RCTs) in English languages. Two independent reviewers complete tasks literature retrieval data extraction. After that, Cochrane Collaboration risk bias tool utilized assess methodological quality....
Moxibusion is a famous traditional Chinese medicine (TCM) treatment, which can be used to treat stable angina pectoris for many years. We will conduct this study explore the efficacy and safety of moxibustion as an additional therapy provide more reliable evidence clinical practice.We go through 8 databases until July 2019 identify related randomized controlled trials that compared with control group. The main result effective rate. RevMan (V.5.3) test sequential analysis (V.0.9) mata trial...