A5100668853- Traditional Chinese Medicine Studies
- Fungal Biology and Applications
- Chronic Kidney Disease and Diabetes
- Food Quality and Safety Studies
- Microbial Natural Products and Biosynthesis
- Cancer, Lipids, and Metabolism
- Corneal Surgery and Treatments
- Pharmacological Effects of Natural Compounds
- Marine Sponges and Natural Products
- Microbial Metabolites in Food Biotechnology
- Neurological Disease Mechanisms and Treatments
- Biochemical effects in animals
- Ocular Surface and Contact Lens
- Enzyme Production and Characterization
- Biomedical Research and Pathophysiology
- Pharmacological Effects and Toxicity Studies
- Probiotics and Fermented Foods
- Antioxidant Activity and Oxidative Stress
- Seaweed-derived Bioactive Compounds
- Genetics and Neurodevelopmental Disorders
- Glycosylation and Glycoproteins Research
- Protein Hydrolysis and Bioactive Peptides
- Pregnancy and preeclampsia studies
- Flavonoids in Medical Research
- Collagen: Extraction and Characterization
Second Hospital of Shanxi Medical University
2022-2024
Shanxi Medical University
2022-2024
Anhui University of Science and Technology
2019-2024
Northeast Normal University
2024
Ocean University of China
2009-2023
Affiliated Hospital of Hebei University
2020-2023
Shandong First Medical University
2005-2021
Qingdao Center of Resource Chemistry and New Materials
2017-2020
Qingdao National Laboratory for Marine Science and Technology
2017-2020
Fujian Agriculture and Forestry University
2019
Abstract The functional and structural changes in the proximal tubule play an important role occurrence development of diabetic kidney disease (DKD). Diabetes-induced metabolic changes, including lipid metabolism reprogramming, are reported to lead state tubular epithelial cells (TECs), among all disturbances metabolism, mitochondria serve as central regulators. Mitochondrial dysfunction, accompanied by increased production mitochondrial reactive oxygen species (mtROS), is considered one...
Abnormal lipid metabolism in renal tubular epithelial cells contributes to accumulation and disturbed mitochondrial bioenergetics which are important diabetic kidney disease. Berberine, the major active constituent of Rhizoma coptidis Cortex phellodendri, is involved regulating glucose metabolism. The present study aimed investigate protective effects berberine on We treated type 2 db/db mice with (300 mg/kg) for 12 weeks. Berberine treatment improved physical biochemical parameters compared...
Purpose: To investigate the therapeutic effects of targeting signal transducer and activator transcription-3 (STAT3) activation on ocular surface damage dry eye in mice. Methods: Adult Balb/C C57BL/6 mice with benzalkonium chloride (BAC) treatment, lacrimal gland excision, meibomian dysfunction were used as models. The levels phosphorylated STAT3 (p-STAT3) detected immunofluorescence staining Western blotting. inhibition was performed by topical application inhibitor S3I-201. Corneal...
// Xiaoping Song 1 , Zhimin Zhao Xin Qi Shuai Tang 2 Qiang Wang 3 Tianjiao Zhu Qianqun Gu Ming Liu Jing Li Key Laboratory of Marine Drugs, Ministry Education, School Medicine and Pharmacy, Ocean University China, Qingdao, P. R. China Division Antitumor Pharmacology, State Drug Research, Shanghai Institute Materia Medica, Chinese Academy Sciences, Shanghai, Department Pharmaceutical South-Central for Nationalities, Wuhan, Correspondence to: Liu, e-mail: lmouc@hotmail.com Li, ljlilac@163.com...
In this research, astaxanthin-rich nanopowder was prepared by nanoencapsulation and freeze-drying techniques with enhanced bioavailability antioxidant activities. The showed a maximum solubility of 230 mg mL-1 an astaxanthin content as high 2.9%. Compared free astaxanthin, the astaxanthin-loaded exhibited more efficient effect: oral dose 0.9 per kg BW significantly reduced malondialdehyde protein carbonyl contents, increased glutathione well superoxide dismutase activities in alcohol-induced...
A filamentous actinomycete strain, designated GW9-2(T), was isolated from a soil sample collected the Fildes Peninsula, King George Island, West Antarctica. The strain identified using polyphasic taxonomic approach. grew slowly on most media tested, producing small amounts of aerial mycelia and no diffusible pigments tested. in presence 0-12 % (w/v) NaCl (optimum, 2-4 %), at pH 9.0-11.0 9.0) 10-37 °C 28 °C). isolate contained meso-diaminopimelic acid, diagnostic sugars MK-9(H4) as...
Three epipolythiodioxopiperazines with two new ones were isolated from a marine-derived fungus, and all of them exhibited extensive cytotoxicity.
A feeding experiment was conducted to evaluate the potential of replacing fish meal (FM, Diet 1) with soybean (SBM, 2), meat and bone (MBM, 3), poultry by‐product (PBM, 4), peanut (PM, 5) in practical diets juvenile large yellow croaker, Pseudosciaena crocea . Five isonitrogenous isoenergetic (43% crude protein 20 kJ/g gross energy on dry matter basis) were formulated. containing FM as main source used a control (Diet 1). Diets 2–5 had 30% replaced SBM, MBM, PBM, or PM protein. Each diet...
Dyslipidemia and oxidative stress injury of blood vessel walls play important roles in the formation atherosclerosis (AS) plaque progression. This is also main pathological basis for atherosclerosis. Statins, as inhibitors HMG-CoA reductase process cholesterol biosynthesis, have become key drugs lipid-lowering treatment. Many studies found anti-atherosclerotic effect atorvastatin far beyond effect. Its effects are involved, such anti-inflammatory, inhibiting endothelial cell ROS production,...
Sulfate polysaccharides can inhibit DNA digestion in simulated gastric juice vitro, which is important for regulating dietary nucleic acids metabolism, but the mechanism of inhibition unclear. This study used dextran sulfate (DS) with different groups and molecular weights to explore effect DS on digestion. Molecular interactions between were investigated by biolayer interferometry (BLI), isothermal titration calorimetry (ITC) dynamics simulations. Results indicated that higher weight group...
Abstract A new pyronepolyene C‐glucoside, iso‐D8646‐2‐6 (I), is isolated together with the known related compound D8646‐2‐6.
The effect of sulfated polysaccharides on the digestion dietary DNA by pepsin was studied using in vitro simulated gastric juice. results showed that fucoidan (FUC), dextran sulfate (DS) and chondroitin (CS) could inhibit a dose-dependent manner. Polysaccharides with high group content have stronger inhibition ability. Fluorescence spectroscopy bind to pepsin, transmission electron microscopy (TEM) confirmed can interact DNA, which not only is main reason but also causes DNase II be...
Vanadium compounds were studied during recent years to be considered as a representative of new class nonplatinum metal anticancer agents in combination its low toxicity. Here, we found vanadium compound Van-7 an inhibitor Topo I other than II using topoisomerase-mediated supercoiled DNA relaxation assay. Agarose gel electrophoresis and comet assay showed that treatment did not produce cleavable complexes like HCPT, thereby suggesting inhibition occurred upstream the relegation step. Further...