A5080336028- Dialysis and Renal Disease Management
- Natural Compounds in Disease Treatment
- Metabolism and Genetic Disorders
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Peroxisome Proliferator-Activated Receptors
- Atherosclerosis and Cardiovascular Diseases
- Sodium Intake and Health
- Potassium and Related Disorders
- Oral Health Pathology and Treatment
- Blood Pressure and Hypertension Studies
- Renal function and acid-base balance
- Cancer, Hypoxia, and Metabolism
- Biomedical Research and Pathophysiology
- Medicinal Plants and Bioactive Compounds
- Nutritional Studies and Diet
- Mitochondrial Function and Pathology
- Hedgehog Signaling Pathway Studies
- Oral microbiology and periodontitis research
- Salivary Gland Disorders and Functions
Second Hospital of Shanxi Medical University
2021-2024
Shanxi Medical University
2021-2024
ORCID
2021
Abstract The functional and structural changes in the proximal tubule play an important role occurrence development of diabetic kidney disease (DKD). Diabetes-induced metabolic changes, including lipid metabolism reprogramming, are reported to lead state tubular epithelial cells (TECs), among all disturbances metabolism, mitochondria serve as central regulators. Mitochondrial dysfunction, accompanied by increased production mitochondrial reactive oxygen species (mtROS), is considered one...
Abstract Objectives To investigate the clinical features and risk factors of Sjogren’s Syndrome (SS) patients suffering from oral candidiasis to provide a foundation for prevention treatment in SS patients. Methods The medical records 479 admitted Second Hospital Shanxi Medical University 2018 2020 were analysed determine characteristics that influence occurrence infection Results Patients with older than those without ( P < 0.05). Male had greater rates Unstimulated whole saliva (UWS)...
Although thunder god vine (Tripterygium wilfordii) has been widely used for treatment of idiopathic membranous nephropathy (IMN), the pharmacological mechanisms underlying its effects are still unclear. This study investigated potential therapeutic targets and mechanism T. wilfordii IMN based on network pharmacology.Active components were obtained from Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform. IMN-associated target genes collected GeneCards, DisGeNET, OMIM...
Renal tubular epithelial cells (TECs) are vulnerable to mitochondrial dysregulation, which is an integral part of diabetic kidney disease (DKD). We found that CD36 knockout ameliorated dysfunction and injury in mice, improved renal function, glomerular hypertrophy, injury, tubulointerstitial fibrosis, cell apoptosis. Furthermore, conferred protection against diabetes-induced restored morphology. also fatty acid oxidation (FAO) enhanced FAO-associated respiration TECs. was alter cellular...
Berberine acts via multiple pathways to alleviate fibrosis in various tissues and shows renoprotective effects. However, its role underlying mechanisms renal remain unclear. Herein, we aimed investigate the protective effects molecular of berberine against unilateral ureteric obstruction-induced fibrosis. The results indicated that treatment (50 mg/kg/day) markedly alleviated histopathological alterations, collagen deposition inflammatory cell infiltration kidney tissue restored mouse...
Abstract Background Tripterygium wilfordii has been widely used for idiopathic membranous nephropathy (IMN), while the pharmacological mechanisms are still unclear. This study is aimed at revealing potential therapeutic targets and mechanism of tripterygium treatment IMN based on network pharmacology. Methods Active components were obtained from Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform. IMN-associated target genes collected GeneCards database, DisGeNET...