Abstract The functional and structural changes in the proximal tubule play an important role occurrence development of diabetic kidney disease (DKD). Diabetes-induced metabolic changes, including lipid metabolism reprogramming, are reported to lead state tubular epithelial cells (TECs), among all disturbances metabolism, mitochondria serve as central regulators. Mitochondrial dysfunction, accompanied by increased production mitochondrial reactive oxygen species (mtROS), is considered one...

Oxidative stress is implicated in the pathogenesis of diabetic kidney injury. SS-31 a mitochondria-targeted tetrapeptide that can scavenge reactive oxygen species (ROS). Here, we investigated effect and molecular mechanism antioxidant peptide on injuries kidneys mouse mesangial cells (MMCs) exposed to high-glucose (HG) ambience. CD-1 mice underwent uninephrectomy streptozotocin treatment prior receiving daily intraperitoneal injection for 8 wk. The treated with had alleviated proteinuria,...

Abstract Tubulointerstitial inflammation plays a key role in the pathogenesis of diabetic nephropathy (DN). Interleukin-1β (IL-1β) is proinflammatory cytokine associated with tubulointerstitial inflammation. The NLRP3 inflammasome regulates IL-1β activation and secretion. Reactive oxygen species (ROS) represents main mediator activation. We previously reported that CD36, class B scavenger receptor, mediates ROS production DN. Here, we determined whether CD36 involved explored underlying...

Abnormal lipid metabolism in renal tubular epithelial cells contributes to accumulation and disturbed mitochondrial bioenergetics which are important diabetic kidney disease. Berberine, the major active constituent of Rhizoma coptidis Cortex phellodendri, is involved regulating glucose metabolism. The present study aimed investigate protective effects berberine on We treated type 2 db/db mice with (300 mg/kg) for 12 weeks. Berberine treatment improved physical biochemical parameters compared...

Abstract: The dysregulation of cholesterol metabolism and inflammation plays a significant role in the progression diabetic nephropathy (DN). Anthocyanins are polyphenols widely distributed food exert various biological effects including antioxidative, anti-inflammatory, antihyperlipidemic effects. However, it remains unclear whether anthocyanins associated with DN, mechanisms involved reciprocal regulation efflux yet to be elucidated. In this study, we evaluated anti-inflammatory exerted by...

Oxidative stress plays an independent role in the pathogenesis of diabetic nephropathy (DN). CD36, a class B scavenger receptor, mediates reactive oxygen species (ROS) production DN. SS31 is mitochondria-targeted antioxidant peptide that can scavenge mitochondrial ROS. The antioxidative effects on DN and interaction between CD36 remain poorly understood. Herein, we examined investigated whether treatment attenuates expression db/db mice high glucose (HG)-induced HK-2 cells.Eight-week-old...

The triglyceride-glucose (TyG) index is a new of insulin resistance (IR), and its association with hyperuricemia (HUA) unclear. aim this study was to investigate whether TyG an independent risk factor for in patients nonalcoholic fatty liver disease (NAFLD).We retrospectively analyzed 461 ultrasound-confirmed NAFLD calculated the index. Multivariate logistic regression used analyze relationship between HUA patients. correlation further confirmed by restricted cubic spline. Furthermore,...

The aim of the present study was to compare characteristics acellular dermal matrix (ADM), small intestinal submucosa (SIS) and Bio‑Gide scaffolds with vascular (ACVM)‑0.25% human‑like collagen I (HLC‑I) scaffold in tissue engineering blood vessels. ACVM‑0.25% HLC‑I prepared compared ADM, SIS via hematoxylin eosin (H&E) staining, Masson staining scanning electron microscope (SEM) observations. Primary human gingival fibroblasts (HGFs) were cultured identified. Then, experiment established...

Intramuscular fat (IMF) is a significant marker for pork quality. The Anqing Six-end-white pig has the characteristics of high meat quality and IMF content. Owing to influence European commercial pigs late start in resource conservation, content within local populations varies between individuals. This study analyzed longissimus dorsi transcriptome purebred with varying recognize differentially expressed genes. We identified 1528 genes (H) low (L) Based on these data, 1775 Gene Ontology...

Although thunder god vine (Tripterygium wilfordii) has been widely used for treatment of idiopathic membranous nephropathy (IMN), the pharmacological mechanisms underlying its effects are still unclear. This study investigated potential therapeutic targets and mechanism T. wilfordii IMN based on network pharmacology.Active components were obtained from Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform. IMN-associated target genes collected GeneCards, DisGeNET, OMIM...

Renal tubular epithelial cells (TECs) are vulnerable to mitochondrial dysregulation, which is an integral part of diabetic kidney disease (DKD). We found that CD36 knockout ameliorated dysfunction and injury in mice, improved renal function, glomerular hypertrophy, injury, tubulointerstitial fibrosis, cell apoptosis. Furthermore, conferred protection against diabetes-induced restored morphology. also fatty acid oxidation (FAO) enhanced FAO-associated respiration TECs. was alter cellular...

Abstract The human CGB 5 gene encodes chorionic gonadotropin ( hCG ) β 5, which is aberrantly expressed in trophoblastic neoplasm and some non‐trophoblastic neoplasms. Fucntional studies observed that it involved tumor initiation, growth, metastatic outgrowth. In this study, using data from the International Cancer Genome Consortium ICGC Atlas TCGA )‐stomach adenocarcinoma STAD ), we assessed independent prognostic value of expression patients with primary gastric cancer GC ). Results showed...

Berberine acts via multiple pathways to alleviate fibrosis in various tissues and shows renoprotective effects. However, its role underlying mechanisms renal remain unclear. Herein, we aimed investigate the protective effects molecular of berberine against unilateral ureteric obstruction-induced fibrosis. The results indicated that treatment (50 mg/kg/day) markedly alleviated histopathological alterations, collagen deposition inflammatory cell infiltration kidney tissue restored mouse...

Acute kidney injury (AKI) is an important cause of chronic disease (CKD), but the underlying mechanisms are unclear. Animal models tools for studying AKI-CKD progression. Kidney ischemia-reperfusion (IRI) models, especially unilateral IRI (uIRI) model with delayed contralateral resection, commonly used to induce fibrotic progression CKD after AKI. However, in previous studies, we found that details operation had a significant impact on long-term outcomes this uIRI model. In study,...

Background Individuals with chronic kidney disease (CKD) are at a substantially higher risk for stroke, which may predispose individuals to cognitive impairment. However, the association of low estimated glomerular filtration rate (eGFR) and albuminuria poorer performance in patients stroke is not fully understood, current evidence this contradictory. Our aim was retrospectively investigate whether eGFR albuminuria, as indicated by urine albumin-creatinine ratio (UACR), independently or...

In the People's Republic of China, as in West, diet has emerged an important determinant morbidity and mortality. order to provide one bases for designing nutrition education, two knowledge-attitudes-practices surveys adults aged 18-55 were conducted 1989 urban (N = 1004) a rural 506) area Sichuan. Nutrition knowledge levels low both sites, but lower site. Certain general concepts, such value varied diet, reported correctly by over 50 per cent population areas. However, less than 10...

Abstract Background Relationships between low estimated glomerular filtration rate (eGFR) and albuminuria with poorer cognitive performance in patients ischemic stroke are less clear. Our aim was to retrospectively ascertain the associations these renal measures stroke. Methods Retrospective analysis performed on 608 acute Urine albumin-creatinine ratio (UACR) eGFR were obtained from inpatient medical records. Global function via mini-mental state exam (MMSE) Montreal Cognitive Assessment...

Abstract Background Tripterygium wilfordii has been widely used for idiopathic membranous nephropathy (IMN), while the pharmacological mechanisms are still unclear. This study is aimed at revealing potential therapeutic targets and mechanism of tripterygium treatment IMN based on network pharmacology. Methods Active components were obtained from Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform. IMN-associated target genes collected GeneCards database, DisGeNET...