A5100337586- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- AI in cancer detection
- Cancer-related gene regulation
- IgG4-Related and Inflammatory Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Pancreatic and Hepatic Oncology Research
- Bioinformatics and Genomic Networks
- Renal cell carcinoma treatment
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Medical Image Segmentation Techniques
- Renal Diseases and Glomerulopathies
- Sarcoma Diagnosis and Treatment
- Digital Imaging for Blood Diseases
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- MRI in cancer diagnosis
- Renal and related cancers
- Prostate Cancer Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- MicroRNA in disease regulation
- Wnt/β-catenin signaling in development and cancer
- Image and Video Quality Assessment
- Viral-associated cancers and disorders
Fudan University
2020-2025
Minhang District Central Hospital
2025
Shanxi Medical University
2011-2024
Second Hospital of Shanxi Medical University
2011-2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Hunan Normal University
2024
Hunan Provincial People's Hospital
2024
Sun Yat-sen University
2024
First Affiliated Hospital of Zhengzhou University
2023
Background: This study investigated prostate cancer (PC)-specific survival and overall (OS) in a population-based castration-resistant PC (CRPC) cohort.Methods: Data from Stockholm Prostate-Specific Antigen (PSA) Biopsy Register patients with increasing PSA despite gonadotropin-releasing hormone treatment or surgical castration (n = 1,712) included values biopsies 2003 to 2015 were linked the National Prostate Cancer Prescribed Drug Register. Kaplan-Meier method estimated PC-specific OS,...
Emerging evidence suggests that dysregulated microRNAs (miRNAs) play a pivotal role in osteoarthritis (OA), but the of specific miRNAs remains unclear. Accordingly, we identified OA-associated and functional validation results. Here, demonstrate miR-218-5p is significantly upregulated moderate severe OA correlates with scores on modified Mankin scale. Through gain-of-function loss-of-function studies, was shown to affect matrix synthesis gene expression chondrocyte proliferation apoptosis....
A minute fraction of patients stands to derive substantial benefits from immunotherapy, primarily attributable immune evasion. Our objective was formulate a predictive signature rooted in genes associated with cytotoxic T lymphocyte evasion (CERGs), the aim predicting outcomes and discerning immunotherapeutic response colorectal cancer (CRC).
Hepatocellular carcinoma (HCC) is one of the leading causes cancer-associated death. Emerging evidence suggests that autophagy plays a critical role in HCC tumorigenesis, metastasis, and prognosis. Choline an essential nutrient related to prolonged survival reduced risk HCC. However, it remains unclear whether this phenomenon mediated by autophagy.
Lung cancer has been a common malignant tumor with leading cause of morbidity and mortality, current molecular targets are woefully lacking comparing to the highly progressive cancer. The study is designed identify new prognostic predictors potential gene based on bioinformatic analysis Gene Expression Omnibus (GEO) database.Four cDNA expression profiles GSE19188, GSE101929, GSE18842 GSE33532 were chosen from GEO database analyze differently expressed genes (DEGs) between non-small cell lung...
The survival rate of breast cancer (BC) patients remains poor, thus the identification safe and effective new drugs is crucial to improve therapeutic outcomes overall survival. Pinocembrin (PCB), a pharmacologically active ingredient Pinus heartwood, Eucalyptus, Euphorbia, Populus, Sparattosperma leucanthum, has been widely applied for treatment various diseases possesses anticancer activities. In vitro assays were performed investigate antiproliferation antimetastasis activities PCB in BC...
The chemotherapy-resistance of triple-negative breast cancer (TNBC) remains a major challenge. Nek2B kinase and β-catenin serve as crucial regulators mitotic processes. aim this study was to test the correlation between TNBC chemotherapy sensitivity, determine regulation on wnt/β-catenin signal pathway.Gene Expression Omnibus(GEO) databases were used gather gene exprsssion data patients who undergoing chemotherapy. co-expression in surgical sections cells analysed by immunohistochemistry,...
Background: TGF-β 1 is a key cytokine involved in both airway inflammation and remodeling asthma because of its anti-inflammatory profibrotic effect. In our previous study, we found that knockdown cytosolic β-catenin alleviated the profibrogenic effect without influencing However, exact role targeting not yet fully demonstrated. present investigated mechanism OVA-challenged asthmatic rats with features. Methods: We integrated experimental model related cell to explore on asthma. Results:...
Abstract Background Clear cell renal carcinoma (ccRCC) has been the commonest (RCC). Although disease classification, diagnosis and targeted therapy of RCC increasingly evolving attributing to rapid development current molecular pathology, clinical treatment situation is still challenging considering comprehensive progressively developing nature malignant cancer. The study identify more potential responsible genes during ccRCC using bioinformatic analysis, thus aiding precise interpretation...
Paired box 6 (PAX6) plays a significant role in the development of human neuroectodermal epithelial tissues. Previous studies have suggested that PAX6 promoter is hypermethylated breast cancer and it involved cell proliferation. The present study aimed to investigate expression invasive tissues, evaluate its prognostic significance. Immunohistochemistry (IHC) was used detect on tissue microarray containing tissues from 111 patients. Associations with staging prognosis were analyzed. mainly...
Renal fibrosis is a major pathological characteristic of diabetic nephropathy (DN). Reportedly, increased SIRT1 expression played renal protective role in animal models DN. This study was designed to elucidate the molecular mechanisms underlying effects SRT1720, an activator, against diabetes-induced fibrosis. Type 2 mice (db/db) were treated with SRT1720 (50 mg/kg/d) by gavage for 10 weeks. proximal tubular epithelial cells (HK-2 cells) high glucose (HG, 30 mM) presence or absence (2.5 µM)...
Abstract Background Lung cancer has been the leading cause of tumor related death, and 80% ~ 85% it is non-small cell lung (NSCLC). Even with rising molecular targeted therapies, for example EGFR, ROS1 ALK, treatment still challenging. The study to identify credible responsible genes during development NSCLC using bioinformatic analysis, developing new prognostic biomarkers potential gene targets disease. Methods Firstly, three expression profiles GSE44077, GSE18842 GSE33532 were picked from...
Various inflammatory biomarkers, such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR), have been well authenticated to predict clinical outcomes in numerous types of cancer. The optimal treatment for patients with locally advanced esophageal squamous cell carcinoma (ESCC) located middle or upper region is still inconclusive. aim study was examine pretreatment NLR PLR select from radical surgery definitive chemoradiotherapy (dCRT) these patients. linkage between...
The aim of this study is to identify the association between histologic types and prognosis hepatoblastoma (HB) in a large Asian cohort single institution explore interaction with other independently risk factors process affecting HB.We retrospectively reviewed 176 children HB (82 female, 94 male) managed our May 1, 2001 July 30, 2014. Prognostic were evaluated using Kaplan-Meier curves Cox proportional hazards models.For entire patients, overall median survival was 80.4 months(95% CI:...
Abstract Background Pancreatic cancer has been a threateningly lethal malignant tumor worldwide. Despite the promising survival improvement in other types attributing to fast development of molecular precise medicine, current treatment situation pancreatic is still woefully challenging since its limited response neither traditional radiotherapy and chemotherapy nor emerging immunotherapy. The study explore potential responsible genes during cancer, thus identifying gene indicators probable...
Population-based studies investigating the association between dietary mineral intake and risk of cervical intraepithelial neoplasia (CIN) or cancer in Chinese women are few. We performed a cross-sectional analysis screening data obtained from 2,304 2014 within an ongoing cohort study comprising 40,000 China. Dietary was assessed using semiquantitative food frequency questionnaire. Nutrition calculated 26-item list sources drawn validated, comprehensive database. All participants were...
To characterize the clinical features of IgG4-related disease (IgG4-RD) and analyze peripheral T lymphocyte subsets cytokine levels.A total 52 patients with newly diagnosed IgG4-RD were enrolled in retrospective study. Baseline characteristics examinational findings systematically reviewed.IgG4-RD had a male predominance, an average age 57.4 ± 10.3 years (range 27-81). The mean number involved organs was 2.7 1-8). Submandibular gland (57.7%) lacrimal gland/orbit (40.4%) most commonly organs....
Awareness of the spectrum clinical manifestations systemic lupus erythematosus (SLE), especially uncommon changes, is essential for diagnosis and effective management patients. A 26-year-old Chinese man with SLE initially manifested cutaneous papulonodular mucinosis developed acute Guillain-Barré syndrome class V nephritis 2 years later. His nodules had not been idententified were resected by surgical procedures twice until was diagnosed. The kidney biopsy revealed nephritis. patient...
Acute kidney injury (AKI) is an important cause of chronic disease (CKD), but the underlying mechanisms are unclear. Animal models tools for studying AKI-CKD progression. Kidney ischemia-reperfusion (IRI) models, especially unilateral IRI (uIRI) model with delayed contralateral resection, commonly used to induce fibrotic progression CKD after AKI. However, in previous studies, we found that details operation had a significant impact on long-term outcomes this uIRI model. In study,...