A5026424442- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Periodontal Regeneration and Treatments
- Tissue Engineering and Regenerative Medicine
- Fibroblast Growth Factor Research
- RNA modifications and cancer
- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Oral Health Pathology and Treatment
- Cancer-related molecular mechanisms research
- Cerebrovascular and Carotid Artery Diseases
- Dental Implant Techniques and Outcomes
- Proteoglycans and glycosaminoglycans research
- Natural product bioactivities and synthesis
- Peptidase Inhibition and Analysis
- Oral and gingival health research
- Flavonoids in Medical Research
- Dermatologic Treatments and Research
- Connective Tissue Growth Factor Research
- Metastasis and carcinoma case studies
- Advanced Glycation End Products research
- Genetics and Neurodevelopmental Disorders
- Chronic Kidney Disease and Diabetes
- Cancer, Hypoxia, and Metabolism
Southwest Medical University
2018-2025
Stomatology Hospital
2018-2025
Nanchang University
2019
Head and Neck Squamous Cell Carcinoma is a malignant tumor with high morbidity mortality. The MMP family plays an important role in invasion metastasis. However, the mechanistic value of as therapeutic target prognostic biomarker HNSC has not been fully elucidated.Oncomine, UALCAN, GEPIA, cBioportal, GeneMANIA, STRING, DAVID6.8, TRRUST, TIMER Linkedomics were used for analysis.The mRNA expression levels MMP1, MMP3, ILF3, MMP7, MMP9, MMP10, MMP11, MMP12, MMP13 MMP16 higher than those normal...
Oxidative stress plays an independent role in the pathogenesis of diabetic nephropathy (DN). CD36, a class B scavenger receptor, mediates reactive oxygen species (ROS) production DN. SS31 is mitochondria-targeted antioxidant peptide that can scavenge mitochondrial ROS. The antioxidative effects on DN and interaction between CD36 remain poorly understood. Herein, we examined investigated whether treatment attenuates expression db/db mice high glucose (HG)-induced HK-2 cells.Eight-week-old...
The aim of the present study was to evaluate proliferation and osteogenic differentiation ability gingiva‑derived mesenchymal stem cells (GMSCs) cultured with different concentrations concentrated growth factors (CGF). GMSCs were isolated from gingival connective tissues characterized by flow cytometry, immunofluorescence staining immunohistochemical staining. Cell activity determined MTT assay, effect CGF on MCSCs detected Counting Kit (CCK)‑8 assay. Mineralization induction evaluated...
Almost 90% of head and neck malignancies are malignant squamous cell cancers, making it the sixth most common malignancy in developing countries, with an overall five-year survival rate about 40%-50%. Early diagnosis treatment can bring a better prognosis. Fibroblast growth factor (FGF) is important polypeptide vivo. Studies have found that FGF signal has carcinogenic potential participates variety behaviors. Some experiments proved function tumor inhibition some cases, role signalling...
The aim of the present study was to compare characteristics acellular dermal matrix (ADM), small intestinal submucosa (SIS) and Bio‑Gide scaffolds with vascular (ACVM)‑0.25% human‑like collagen I (HLC‑I) scaffold in tissue engineering blood vessels. ACVM‑0.25% HLC‑I prepared compared ADM, SIS via hematoxylin eosin (H&E) staining, Masson staining scanning electron microscope (SEM) observations. Primary human gingival fibroblasts (HGFs) were cultured identified. Then, experiment established...
Our study aimed to explore potential new diagnostic biomarkers in patients with oral squamous cell carcinoma (OSCC) find target molecules involved the progression of OSCC. Potential novel OSCC were identified using a protein microarray assay. Compared healthy control group, there five proteins (I309, GDF15, AXL, MMP3, and CTACK) serum situ cancer group. However, four differentially expressed (MCSF, I309, Receiver operating characteristic (ROC) curve analysis results suggested that these six...
To analyze the mechanism of how interfering with cytokeratin 19 (CK19) pathway via ferroptosis affects tumor biological behaviors in process oral squamous cell carcinoma (OSCC) development. TCGA was used to expression CK19 pan-cancer and head neck (HNSC) explore ferroptosis-related genes related HNSC. The effect silencing on migration ability HSC-4 cells verified by wound healing assay. tumor-bearing nude mouse model were constructed. RT-qPCR, immunofluorescence western blot genes. is highly...
To explore diagnostic and prognostic biomarkers in the progression of oral squamous cell carcinoma (OSCC) to reveal their regulatory mechanisms key pathways. A RayBiotech protein chip was used screen differentially expressed serum proteins OSCC, leukoplakia (OLK), healthy participants. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analysis were determine pathways enriched by characteristic differential proteins. Immunohistochemical western blotting verify expression...
Purpose To explore the feasibility of constructing tissue-engineered vascularised oral mucosa-like structures with rabbit ACVM-0.25% HLC-I scaffold and human gingival fibroblasts (HGFs), epithelial cells (HGECs) vascular endothelial-like (VEC-like cells).Method Haematoxylin Eosin (H&E) staining, immunohistochemical, immunofluorescence, 5-ethynyl-2′-deoxyuridine (EdU) staining scanning electron microscope (SEM) were performed to detect growth status on complex. After complex implanted into...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL The Significance and Consideration of Standardizing the Critical Value for Maximum Bone Defect Construction Animal Models Tissue Engineering Regeneration Heliyon 47 Pages Posted: 23 Feb 2024 Publication Status: Under Review See all articles by Jian WeiJian WeiSouthwest Medical UniversityXiao Chenaffiliation not provided SSRNYingjiao XuSouthwest...
This study aimed to explore the expression trends of innate immune cells and immune-checkpoint molecules validated by data calculation in process oral mucosal carcinogenesis, as well methods suppressing carcinogenesis based on immunotherapy predicting their interactions.
Objective: This study aimed to analyze the expression of Matrix Metalloproteinase 7 (MMP7) and molecular mechanism at Transcription Factor (TF) level in Oral Squamous Cell Carcinoma (OSCC). Methods: MMP7 was preliminarily explored Head Neck Car-cinoma (HNSCC) online database, followed by functional analysis prediction TF MMP7. IHC employed detect levels OSCC samples. SCC9 293T cells were used explore transcriptional regulatory effects predicted on reporter double luciferase assay, RT-qPCR,...
<title>Abstract</title> Oral squamous cell carcinoma has a high incidence rate in the population and metastasis rate. Despite ongoing improvements by clinicians diagnosis treatment, effective enhancement of survival rates remains elusive. In this study, it was found that MMP-3 can promote formation vascular mimicry oral carcinoma, facilitating tumor cells invasion metastasis. Survival analysis reveals negative correlation between matrix metalloproteinase 3 overall patients; multivariable Cox...
Background: The human-like collagen I (HLC-I) combined concentrated growth factors was used to construct CGF-HLC-I composite biomaterials repair the critical bone defect disease model of rabbit mandible. This study aimed research mechanism CGF-HLC-I/Bio-Oss in mandibular defect, provide a new treatment direction for clinical repair. Methods: optimal concentration HLC-I (0.75%) selected this study. Nine New Zealand white rabbits were randomly divided into 3 groups, normal control group,...
This work aimed to determine the expression changes in LIM domain only protein 1 (LMO1) gene transcription and levels during oral squamous cell carcinoma (OSCC) development.The tissues this study were taken from our team's previous animal model building, we performed hematoxylin-eosin (HE) staining on 49 cases. The pathological classification of experiment group was determined basis abnormal epithelial hyperplasia degree. part LMO1 by immunohistochemistry staining. mRNA five groups detected...