A5089153368- Nutrition and Health in Aging
- Genetics and Physical Performance
- Muscle Physiology and Disorders
- Frailty in Older Adults
- Body Composition Measurement Techniques
- Muscle metabolism and nutrition
- Balance, Gait, and Falls Prevention
- Epigenetics and DNA Methylation
- Gait Recognition and Analysis
- GDF15 and Related Biomarkers
- Cerebral Palsy and Movement Disorders
- Video Surveillance and Tracking Methods
- Face recognition and analysis
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- Nutrition, Genetics, and Disease
- Sports Performance and Training
- Apelin-related biomedical research
- Atrial Fibrillation Management and Outcomes
- Human Pose and Action Recognition
- Natural product bioactivities and synthesis
- Biochemical effects in animals
- Advanced Steganography and Watermarking Techniques
- Occupational and environmental lung diseases
Xiamen University
2022-2025
Meizu (China)
2024
Southwest Medical University
2024
Sichuan University
2024
Huazhong University of Science and Technology
2024
Tongji Hospital
2024
KU Leuven
2018-2022
Manchester Metropolitan University
2019-2022
Centre Hospitalier Universitaire de Toulouse
2022
Tobacco Research Institute
2022
Abstract Neurofilament light chain (NfL) has been associated with cognitive status in multiple neurodegenerative conditions. Studies about plasma NfL and decline older adults are still limited. 504 (median age 75 years) who expressed memory complaints were selected from the Multidomain Alzheimer’s Preventive Trial (MAPT) classified as normal cognition (NC) or mild impairment (MCI). Cognitive functions measured mini mental state examination (MMSE) composite score (CCS) over a 4-year period....
Abstract Background Radiofrequency catheter ablation (RFCA) may lead to decreased quality of life (QOL) and increased anxiety depression in patients with paroxysmal supraventricular tachycardia (PSVT), possibly due the lack selectivity tissue long time. In recent years, pulsed field (PFA) has been used for first time China treat PSVT because its ability ablate abnormal sites a precise transient manner. This study was conducted compare effects PFA RFCA on QOL psychological symptoms patients....
Abstract Background Intrinsic capacity (IC) is the composite of an individual's physical and mental capacities. However, association between IC trajectories falls hospitalizations remains uncertain. This study aimed to determine among older adults, investigating its with subsequent risk hospitalizations. Methods enrolled 3,902 adults aged ≥65 from National Health Aging Trends Study (NHATS, wave 2015-2019). A bi-factor model was used for repeated measurements five domains generate scores four...
Abstract Background Identification of simple screening tools for detecting lower skeletal muscle mass may be beneficial planning effective interventions in the elderly. Aims We aimed to (1) establish a threshold one-leg standing balance test (OLST) time low mass, and (2) ability that assess muscular impairments poor group. Methods Eyes-open OLST (maximum duration 30 s) was performed with right left legs 291 women (age 71 ± 6 years). calculated as sum legs. Fat-free (FFM), (SMM), fat biceps...
Abstract Background Cognition is closely associated with physical function. Although high brain amyloid-β (Aβ) deposition and neurofilament light chain (NfL) are cognitive gait speed decline, relationships of combined plasma Aβ NfL profiles functions in older adults remain unknown. The research aim this study was to investigate the prospective associations adults. Methods Participants ( n = 452, aged 76 ± 5 years) who had both data collected from Multidomain Alzheimer’s Preventive Trial...
Abstract The prevalence of sarcopenia depends on the definition used. There are, however, consistent sarcopenic characteristics, including a low muscle mass and strength. Few studies have investigated relationship between genotype. A cross-sectional study was conducted with 307 community-dwelling ≥60-year-old women in South Cheshire, UK. Handgrip strength assessed handgrip dynamometer skeletal estimated using bioelectrical impedance. DNA extracted from saliva (∼38%) or blood (∼62%) 24...
Abstract Background Sarcopenia is characterized by progressive decreases in muscle mass, strength, and function with ageing. Although many studies have investigated the mechanisms of sarcopenia, its connection epigenetic factors, such as DNA methylation, still remains poorly understood. The aim this study was to explore sarcopenia‐related methylation differences blood samples between age‐matched sarcopenic non‐sarcopenic older women. Methods A group ( n = 24) identified selected from a set...
Obesity may aggravate the effects of sarcopenia on skeletal muscle structure and function in elderly, but no study has attempted to identify gene variants associated with obese women. Therefore, aims present were to: (1) describe neuromuscular sarcopenic non-sarcopenic women or without obesity; (2) older In 307 Caucasian (71 ± 6 years, 66.3 11.3 kg), mass was estimated using bioelectric impedance, tested a 30 s one-leg standing-balance test. Biceps brachii thickness vastus lateralis...
Aim Previous studies have shown that chronic diseases are strongly linked to the development of sarcopenia. Few assessed relationship between multimorbidity patterns and This study aimed investigate impact on sarcopenia transitions in Chinese older adults. Methods A total 3842 adults (aged 66.7 ± 6.2 years) with complete data at baseline least one follow‐up record (2 were included from China Health Retirement Longitudinal Study. Multimorbidity identified using latent class analysis....
There is a scarcity of studies that have investigated the role multiple single nucleotide polymorphisms (SNPs) on range muscle phenotypes in an elderly population. The present study possible association 24 SNPs with skeletal 307 Caucasian women (aged 60–91 years, 66.3 ± 11.3 kg). Skeletal included biceps brachii thickness, vastus lateralis cross-sectional areas, maximal hand grip strength, isometric knee extension and elbow flexion torque. Genotyping for SNPs, chosen their structural or...
Abstract Background Inter‐individual variance in skeletal muscle is closely related to genetic architecture and epigenetic regulation. Studies have examined relationships with characteristics of ageing separately, while no study has combined both profiles research. The aim this was evaluate the association between methylation scores phenotypes older women. Methods Forty‐eight Caucasian women (aged 65–79 years) were included study. Biceps brachii thickness vastus lateralis anatomical...
Abstract Background Growth differentiation factor 15 (GDF15) has been associated with several age-related disorders, but its associations functional abilities in community-dwelling older adults are not well studied. Methods The study was a secondary analysis of 1 096 (aged 69–94 years) recruited from the Multidomain Alzheimer’s Preventive Trial. Plasma GDF15 measured year after participants’ enrollment. Annual data physical performance (grip strength and Short Physical Performance Battery...
Abstract Background Plasma amyloid-beta (Aβ), neurofilament light chain (NfL), and progranulin (PGRN) have been related to multiple neurodegenerative conditions that might affect physical performance. The aim of this study was explore the relationship between these plasma markers performance among community-dwelling older adults. Methods Five hundred seven adults (aged 76 ± 5 years) previously recruited in Multidomain Alzheimer’s Preventive Trial, had received blood tests, were included...
<b><i>Introduction:</i></b> Routine blood factors can be economical and easily accessible candidates for sarcopenia screening monitoring. The associations between routine remain unclear. This study aimed to examine factor based on a nation-wide cohort in China. <b><i>Methods:</i></b> A total of 1,307 participants 17 indices were selected from two waves (year 2011 year 2015) the China Health Retirement Longitudinal Study (CHARLS). diagnosis was...
Apelin and GDF-15 have been proposed as biomarkers of age-related sarcopenia but evidence in human models is scarce. This study aimed to explore the associations between blood apelin with incidence evolution components over two years older adults >70 years.
Background: Heritability explains 45-82% of muscle mass and strength variation, yet polygenic models for phenotypes in older women are scarce. Therefore, the objective present study was to (1) assess if total genotype predisposition score (GPSTOTAL) a set polymorphisms differed between with low high mass, (2) utilise data-driven GPS (GPSDD) predict variance size strength-related phenotypes. Methods: In three-hundred 60- 91-year-old Caucasian (70.7 ± 5.7 years), skeletal biceps brachii...
Although multiple nutrients have shown protective effects with regard to preserving muscle function, the recommended amount of dietary protein and other profile on older adults for maintenance high mass is still debatable. The aims this paper were to: (1) identify differences between women low relative skeletal mass, (2) minimal intake associated test threshold ability determine an association phenotypes. Older (n = 281; 70 ± 7 years, 65 14 kg), both groups, completed a food questionnaire....
Abstract Objective: The aim of the study was to explore association between angiotensin-converting enzyme ( ACE ) gene insertion/deletion (I/D) polymorphism and muscle adaptations moderate-intensity resistance training in postmenopausal women. Methods: Forty healthy Chinese women (aged 53-66 years) were recruited grouped by I/D (the homozygous deletion genotype [DD], n = 12; I allele carriers [II/ID], 28). All participants performed an 8-week full-body program at moderate intensity with...
Background and purpose: This prospective observational study aimed to investigate the occurrence of avascular necrosis (AVN) femoral head in COVID-19 patients through MRI scans. The examined patterns AVN 110 individuals who had undergone conventional therapy reported hip discomfort. highlights importance considering as a potential complication therapy, particularly younger experience Methods: Individuals corticosteroid treatment for experienced discomfort during 6 months between January 2022...