A5074314866- Nutrition and Health in Aging
- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Body Composition Measurement Techniques
- Nutritional Studies and Diet
- Dementia and Cognitive Impairment Research
- Vitamin D Research Studies
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- ATP Synthase and ATPases Research
- Diet and metabolism studies
- Aging, Elder Care, and Social Issues
- Pharmaceutical Practices and Patient Outcomes
- Geriatric Care and Nursing Homes
- Health, Medicine and Society
- Folate and B Vitamins Research
- GDF15 and Related Biomarkers
- Bone health and osteoporosis research
- Chronic Disease Management Strategies
- Cardiovascular Health and Risk Factors
- Cardiovascular Function and Risk Factors
- Pharmacological Effects and Toxicity Studies
- Cardiovascular Health and Disease Prevention
- Radiation Dose and Imaging
- Dental Health and Care Utilization
Université de Toulouse
2011-2024
Centre Hospitalier Universitaire de Toulouse
2008-2024
Université Toulouse III - Paul Sabatier
2011-2024
Inserm
2011-2024
Institut de Mathématiques de Toulouse
2023-2024
Institute on Aging
2024
Centre d'Étude et de Recherche Travail Organisation Pouvoir
2024
Centre de recherche en Epidémiologie et Santé des Populations
2023
Yves Rocher (France)
2023
Médipole Garonne
2013-2020
<i>Background:</i> Hypovitaminosis D has been cross-sectionally associated with dementia and stroke. The objective of this longitudinal study was to determine whether serum vitamin deficiency at baseline could predict the onset non-Alzheimer dementias (NAD) within 7 years among older women. <i>Methods:</i> Forty high-functioning women (78.4 years, 76.4/82.0; median, 25th/75th percentile) from EPIDOS Toulouse were divided into two groups based on (i.e.,...
Abstract Background The way physical activity (PA) and sedentary behaviour (SB) independently interactively modify the age‐related decline in capacity remains poorly understood. This cross‐sectional study investigated independent interactive associations of PA SB with function performance throughout adult life course. Methods Data from 499 community‐dwelling adults (63% female) aged 20–92 years, involved INSPIRE Human Translational Cohort, were used this study. Daily time spent on...
Cognitive impairment, slow walking speed and motoric cognitive risk syndrome (MCR) have separately been associated with an increased for mortality in the short term. The aim of study was to examine association MCR its components [i.e. subjective complaint (SCC) speed] short-, medium- long-term older community-dwellers.In all, 3778 participants from Epidémiologie de l'Ostéoporose (EPIDOS) were selected. defined as combination SCC without major neurocognitive disorders. Deaths prospectively...
Abstract The secreted peptide adropin is highly expressed in human brain tissues and correlates with RNA proteomic risk indicators for dementia. Here we report that plasma concentrations predict cognitive decline the Multidomain Alzheimer Preventive Trial (ClinicalTrials.gov Identifier, NCT00672685; mean age 75.8y, SD = 4.5 years, 60.2% female, n 452). Cognitive ability was evaluated using a composite score (CCS) assessed four domains: memory, language, executive function, orientation....
Abstract Introduction Multinutrient approaches may produce more robust effects on brain health through interactive qualities. We hypothesized that a blood‐based nutritional risk index (NRI) including three biomarkers of diet quality can explain cognitive trajectories in the multidomain Alzheimer prevention trial (MAPT) over 3‐years. Methods The NRI included erythrocyte n‐3 polyunsaturated fatty acids (n‐3 PUFA 22:6n‐3 and 20:5n‐3), serum 25‐hydroxyvitamin D, plasma homocysteine. scores...
Vitamin D intake may prevent physical performance decline through prevention of muscle mass loss. Our objective was to determine whether low dietary intakes were associated with (MM).
Abstract Background Plasma amyloid-beta (Aβ), neurofilament light chain (NfL), and progranulin (PGRN) have been related to multiple neurodegenerative conditions that might affect physical performance. The aim of this study was explore the relationship between these plasma markers performance among community-dwelling older adults. Methods Five hundred seven adults (aged 76 ± 5 years) previously recruited in Multidomain Alzheimer’s Preventive Trial, had received blood tests, were included...
Abstract Background The Integrated Care for Older People (ICOPE) approach was developed by the World Health Organization (WHO) aiming to shift traditional focus of care based on diseases a function- and person-centered approach, focused maintaining monitoring intrinsic capacity (IC). This study aimed investigate ability ICOPE screening tool identify older people with clinically meaningful impairments in IC domains. Methods cross-sectional analysis included 603 adults, participants (mean age...
Abstract Although most drugs currently approved are meant to treat specific diseases or symptoms, it has been hypothesized that some might bear a beneficial effect on lifespan in healthy older individuals, outside of their disease indication. Such include, among others, metformin, SGLT2 inhibitors and rapamycin. Since 2006, the UK biobank recorded prescription medication mortality data for over 500′000 participants, aged between 40 70 years old. In this work, we examined impact top 406...
To examine frailty determinants differences in patients with a recent diagnosis of cancer compared to non-cancer among older adult. Revealing those will allow us individualize the exact management diagnosed cancer.