Claire Gervais
A5086928731- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Crystallization and Solubility Studies
- Cultural Heritage Materials Analysis
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Analytical Chemistry and Chromatography
- Building materials and conservation
- Crystallography and molecular interactions
- Nutrition and Health in Aging
- Pigment Synthesis and Properties
- Dementia and Cognitive Impairment Research
- Ferroptosis and cancer prognosis
- X-ray Diffraction in Crystallography
- Diet and metabolism studies
- Biosimilars and Bioanalytical Methods
- Frailty in Older Adults
- Fatty Acid Research and Health
- Corrosion Behavior and Inhibition
- Inflammatory Biomarkers in Disease Prognosis
- Nutritional Studies and Diet
- GDF15 and Related Biomarkers
- Protein Structure and Dynamics
Hôpital Européen
2021-2025
University of Wisconsin Health
2025
Hôpital Européen Georges-Pompidou
2016-2024
Université Paris Cité
2018-2024
Assistance Publique – Hôpitaux de Paris
2016-2024
Inserm
2020-2023
La Ligue Contre le Cancer
2021-2023
Institut Cochin
2020-2023
Centre National de la Recherche Scientifique
2020-2023
Observatoire de la Côte d’Azur
2021-2022
Abstract Prussian blue is a pigment highly sensitive to electromagnetic radiation, visible light included. This photosensitivity, associated with complex redox behavior, causes vulnerability even Raman lasers, the possibility of sample alteration or irreversible damage. In this study, we systematically explored influence laser wavelength and power on different types pigments, soluble insoluble. The use wavelengths does not position characteristic peak, though it affects signal‐to‐noise...
Abstract Background The 18-gene tumor inflammation signature (TIS) is a clinical research assay that enriches for benefit to immune checkpoint blockade. We evaluated its ability predict of immunotherapy in cancer patients treated with PD-1 inhibitors routine care. Methods CERTIM cohort prospective which includes receiving Cochin University hospital. RNA extracted from 58 archival formalin fixed paraffin embedded blocks (including 38 lung cancers, 5 melanomas, 10 renal carcinomas, 4...
Adoptive transfer of T cells expressing chimeric antigen receptors (CAR) has shown remarkable clinical efficacy against advanced B-cell malignancies but not yet solid tumors. Here, we used fluorescent imaging microscopy and ex vivo assays to compare the early functional responses (migration, Ca2+, cytotoxicity) CD20 EGFR CAR upon contact with malignant B carcinoma cells. Our results indicated that rapidly form productive ICAM-1-dependent conjugates their targets. By comparison, only...
<h2>Summary</h2><h3>Background</h3> It is unknown whether multidomain interventions, which might preserve late-life cognition, affect Alzheimer's disease pathology. Previous studies measured cerebrospinal fluid and imaging biomarkers in small subsamples of trial participants. Newly developed assays enable the measurement blood-based larger samples. We aimed to assess plasma tau phosphorylated at threonine 181 (p-tau181) was able detect or predict 3-year intervention effects. <h3>Methods</h3>...
Abstract Neurofilament light chain (NfL) has been associated with cognitive status in multiple neurodegenerative conditions. Studies about plasma NfL and decline older adults are still limited. 504 (median age 75 years) who expressed memory complaints were selected from the Multidomain Alzheimer’s Preventive Trial (MAPT) classified as normal cognition (NC) or mild impairment (MCI). Cognitive functions measured mini mental state examination (MMSE) composite score (CCS) over a 4-year period....
Abstract Background Vitality is conceptually considered as the underlying capacity influencing other intrinsic (IC) domains and being related to nutrition, physiological reserve biological ageing. However, there no consensus on its operationalisation. Objective To investigate structure magnitude of association vitality with IC functional difficulties using three operational definitions vitality. Methods We included 1,389 older adults from Multidomain Alzheimer Preventive Trial data Mini...
Prussian blue (PB) and its analogues are widely studied because of their interesting promising magnetic optical properties. The pigment blue, found in different types artworks (paintings, watercolors photographs), is also the area heritage science, where capricious fading behavior under light or anoxia treatment poses problematic conservation issues. PB due to reduction iron(III) iron(II) depends significantly on artefact. This paper focuses roles substrate affecting structure modifying...
Physical activity (PA) demonstrated benefits on brain health, but its relationship with blood biomarkers of neurodegeneration remains poorly investigated. We explored the cross-sectional associations PA concentrations neurofilament light chain (NFL) and beta amyloid (Aβ)42/40. further examined whether interaction between these was longitudinally related to cognition. Four-hundred sixty-five nondemented older adults engaged in an interventional study who had a concomitant assessment levels...
Abstract Background Cognition is closely associated with physical function. Although high brain amyloid-β (Aβ) deposition and neurofilament light chain (NfL) are cognitive gait speed decline, relationships of combined plasma Aβ NfL profiles functions in older adults remain unknown. The research aim this study was to investigate the prospective associations adults. Methods Participants ( n = 452, aged 76 ± 5 years) who had both data collected from Multidomain Alzheimer’s Preventive Trial...
Abstract The secreted peptide adropin is highly expressed in human brain tissues and correlates with RNA proteomic risk indicators for dementia. Here we report that plasma concentrations predict cognitive decline the Multidomain Alzheimer Preventive Trial (ClinicalTrials.gov Identifier, NCT00672685; mean age 75.8y, SD = 4.5 years, 60.2% female, n 452). Cognitive ability was evaluated using a composite score (CCS) assessed four domains: memory, language, executive function, orientation....
Although the title compound crystallizes as a stable conglomerate without any detectable solid solution, particles in shape of single crystals grown from racemic aqueous solution stirring contain almost no enantiomeric excess. From stereoselective dissolution experiments carried out saturated with enantiomer, it is shown that formation these results epitaxial association macroscopic homochiral lamellar fragments parallel to {101} faces. This alternated 2D nucleation and growth process...
IPANEMA, a research platform devoted to ancient and historical materials (archaeology, cultural heritage, palaeontology past environments), is currently being set up at the synchrotron facility SOLEIL (Saint-Aubin, France; opened users in January 2008). The new open French, European international users. activities of are centred on two main fields: increased support projects methodological research. IPANEMA team occupies temporary premises SOLEIL, but comprises construction building that...
Although Prussian blue is a popular pigment, its stability has been questioned since discovery in 1704. Its upon exposure to light and anoxia remains difficult apprehend. The present paper focuses on the relative influences of light, type substrate discoloration dyed textiles. Spectrophotometry X-ray absorption spectroscopy measurements samples artificially aged by air or show that both extent reduction process at origin aging textile are linked strongly differ with environment. complex...
Beside its promising applications in the design of multifunctional materials, batteries and biosensors, pigment Prussian blue is still studied heritage science because capricious fading behavior due to a complex light-induced redox mechanism. We model materials composed embedded into cellulosic fiber substrate by means X-ray absorption near-edge spectroscopy. Significant radiation damage was observed characterized. induced first reduction blue, similar way what visible light does, followed...
Factors associated with olaparib toxicity remain unknown in ovarian cancer patients. The large inter-individual variability pharmacokinetics could contribute to the onset of early significant adverse events (SAE). We aimed retrospectively analyze pharmacokinetic/pharmacodynamic relationship for patients from “real life” data. clinical endpoint was SAE (grade III/IV or dose reduction/discontinuation). Plasma concentration assayed using liquid chromatography at any time over dosing interval....
Background and objectives Low eGFR is known to be associated with frailty, but the association between longitudinal decline of incident frailty in older persons remains determined. The objective this study was investigate whether a fast on would frailty. Design, setting, participants, & measurements Community dwellers, aged ≥70, were included secondary analysis 5-year Multidomain Alzheimer Preventive Trial (MAPT). calculated using CKD–Epidemiology Collaboration equation at baseline 6,...