A5005575391- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition and Health in Aging
- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Healthcare Systems and Reforms
- Nutritional Studies and Diet
- Geriatric Care and Nursing Homes
- Intergenerational Family Dynamics and Caregiving
- Aging, Health, and Disability
- Diet and metabolism studies
- Aging and Gerontology Research
- Non-Invasive Vital Sign Monitoring
- Climate Change and Health Impacts
- Chronic Disease Management Strategies
- GDF15 and Related Biomarkers
- Neuroinflammation and Neurodegeneration Mechanisms
- Delphi Technique in Research
- Air Quality and Health Impacts
- Public Health and Social Inequalities
- Musculoskeletal pain and rehabilitation
- Intensive Care Unit Cognitive Disorders
- Global Health Care Issues
- Aging, Elder Care, and Social Issues
- Health, Medicine and Society
Université Toulouse III - Paul Sabatier
2021-2025
Université de Toulouse
2021-2025
Inserm
2021-2025
Institut de Mathématiques de Toulouse
2020-2024
Instituto Nacional de Salud Pública
2019-2024
Centre Hospitalier Universitaire de Toulouse
2021-2023
Médipole Garonne
2023
Centre de recherche en Epidémiologie et Santé des Populations
2023
King's College London
2023
Institute of Aging
2022
Abstract Background How inflammation relates to intrinsic capacity (IC), the composite of physical and mental capacities, remains undefined. Our study aimed investigate cross‐sectional longitudinal associations between plasma inflammation‐related biomarkers IC in older adults. Methods This secondary analysis Multidomain Alzheimer Preventive Trial (MAPT) included 1238 community‐dwelling individuals with assessments from 12 60 months. Plasma C‐reactive protein (CRP), interleukin‐6 (IL‐6),...
The aim of this study was to compare a short and long version an intrinsic capacity index test their cross-sectional association with relevant health outcomes in older adults. Cross-sectional analysis the baseline data FraDySMex study. 543 community-dwelling adults aged 50 years living 2 municipalities Mexico City, from which 435 had complete on variables interest. indices were obtained using principal components analysis. performance tested respective frailty, IADL ADL. versions IC...
Abstract Background intrinsic capacity (IC) is a construct encompassing people’s physical and mental abilities. There an implicit link amongst IC domains: cognition, locomotion, nutrition, sensory psychological. However, little known about the integration of domains. Objectives to investigate patterns in presentation evolution domain impairments low-and-middle-income countries if such were associated with adverse outcomes. Methods secondary analyses first two waves 10/66 study...
The vitality domain of intrinsic capacity (IC) represents the synthesis biological interactions and metabolism. As part Integrated Care for Older People (ICOPE) program developed by World Health Organization (WHO), focuses on nutritional status older adults. objective this work was to describe IC in community-dwelling people examine associations components (appetite loss weight loss) with other domains assessed within framework ICOPE.Cross-sectional data were obtained between January 2020...
Abstract BACKGROUND The mechanisms linking mild behavioral impairment (MBI) and Alzheimer's disease (AD) have been insufficiently explored, with conflicting results regarding tau protein few data on other metabolic markers. We aimed to evaluate the longitudinal association of MBI domains a spectrum plasma biomarkers. METHODS Our study is secondary analysis from NOLAN. biomarkers, including pTau181, was tested using adjusted linear mixed‐effects models. RESULTS sample comprised 359...
The aim of this study is to evaluate the association systemic inflammation measured by plasma biomarkers with change in cognitive function among participants from Multidomain Alzheimer Preventive Trial (MAPT) exposed multidomain intervention (MI). Secondary analysis MAPT longitudinal data. a randomized, placebo-controlled trial 3 interventional groups (omega-3 only, MI omega-3 plus MI) and control group. We tested inflammatory (tumoral necrosis factor receptor-1 (TNFR1), monocyte...
Background/Objectives: In primary care, tailored physical activity and nutritional counselling are scarce for older adults. Several challenges contribute to this issue, the obstacle being limited access expert healthcare providers. The purpose of study was propose a quick, easy-to-implement case-finding tool offering straightforward overcome these barriers. Methods: Cross-sectional, baseline analysis performed on 277 participants Cognitive Function Amyloid Marker in Frail Older Adults...
Abstract Background Vitality is conceptually considered as the underlying capacity influencing other intrinsic (IC) domains and being related to nutrition, physiological reserve biological ageing. However, there no consensus on its operationalisation. Objective To investigate structure magnitude of association vitality with IC functional difficulties using three operational definitions vitality. Methods We included 1,389 older adults from Multidomain Alzheimer Preventive Trial data Mini...
Abstract Aging is characterized by several major changes, including altered body composition, which associated with numerous negative clinical consequences such as sarcopenia, osteoporosis, and frailty. The study to evaluate composition parameters depending on age sex in a population ranging from the young adult very old, identify break points association between age. In this cross-sectional study, we included enrolment of French INSPIRE-T prospective cohort, accounting for 915 subjects (62%...
To evaluate the social factors associated with tobacco and alcohol consumption in Mexican adolescents from populations under 100 000 inhabitants.Cross-sectional study based on National Health Nutrition Survey (Ensanut100k). It included between 10-19 years. Adjusted logistic regression models were estimated, obtaining Odds Ratio (OR) confidence intervals 95% (CI95%).Prevalence of last month was 5.5% (10-14 years= 1.0%, 15-19 11.2%); 9.3%, excessive consumption, 2.8%. Associated factors:...
Abstract Background The 5-repetition chair stand test (CST) is increasingly being used to assess locomotion capacity in older adults. However, there a lack of age-stratified cutoffs for adults aged ≥70 validated against higher risk functional loss. Methods We 2 population-based studies (Study on global AGEing and adult health Mexico [SAGE Mexico] Toledo Study Healthy Aging [TSHA]) receiver operating characteristic (ROC) analyses develop cross-validate with activities daily living (ADL)...
To examine the longitudinal association between social determinants of health (SDH) and frailty status with all-cause mortality in older Mexican adults.Longitudinal study a sample adults aged 60 over Study on Global AGEing Adult Health (SAGE) Mexico. A Cox proportional hazard model was used to estimate SDH frailty-related ratios (HR) for period.Overall rate 16.9%. Higher education, having higher frequency inter-personal contacts (HR=0.96; p<0.01) reduced risk dying, after adjusting potential...
The Region of the Americas is facing accelerated demographic and epidemiological changes. As these trends will continue in future years, long-term care needs are expected to rise. How can countries respond challenges? We propose that should invest implementation systems. Considering heterogeneity Region, we a strategy based on three components: (i) understanding problem; (ii) thinking about solutions; (iii) building support consensus. Depending each country's capacities, elements suggest...
To identify key indicators that will allow empirical measurement of a health system's responsiveness to older people.We conducted series consultations with experts develop relevant list indicators. Concept mapping was used devise the list, including steps preparation, brainstorming and structuring. Additionally, four countries were as national case studies test feasibility measuring system readily available national-level data (Barbados, Brazil, Chile, Mexico).Our study resulted in 25 scored...