A5102877062- Synthesis of β-Lactam Compounds
- Advanced Drug Delivery Systems
- Acupuncture Treatment Research Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Health, Environment, Cognitive Aging
- Chemical Reactions and Isotopes
- Pharmacogenetics and Drug Metabolism
- Frailty in Older Adults
- Enhanced Oil Recovery Techniques
- Traditional Chinese Medicine Studies
- Advanced Welding Techniques Analysis
- Electrospun Nanofibers in Biomedical Applications
- Gout, Hyperuricemia, Uric Acid
- Health Systems, Economic Evaluations, Quality of Life
- Pickering emulsions and particle stabilization
- Wound Healing and Treatments
- Streptococcal Infections and Treatments
- Reservoir Engineering and Simulation Methods
- Materials Engineering and Processing
- Chronic Kidney Disease and Diabetes
- Sirtuins and Resveratrol in Medicine
- Marine and Offshore Engineering Studies
- Hydrogels: synthesis, properties, applications
- Advancements in Transdermal Drug Delivery
- Innovations in Concrete and Construction Materials
Xiamen University
2024-2025
Yancheng First People's Hospital
2024
Nantong University
2024
Jilin Maternity and Child Health Care Hospital
2022-2024
Shanghai Jiao Tong University
2022
Jilin University
2017-2021
University College London
2021
Jilin Medical University
2021
Shenyang Pharmaceutical University
2018-2020
Shenyang Medical College
2019
In nasal drug delivery system, spray seems to be the most promising method for both local and systemic diseases therapy. Nasal deposition behavior is basic important process sprays, which related mucociliary clearance, retention of a formulation in nose therefore therapeutic effect. The present paper systemically summarized discussed factors influencing cavity upon via including device, administration techniques. Emitted dose volume pattern plume geometry, droplet size distribution velocity...
to examine a 16-year trend in cognitive impairment (CI) incidence and associated factors among older Chinese people.aged 60 above whose function were normal at their first test.a secondary analysis that identified subjects from the database of Longitudinal Healthy Longevity Survey (CLHLS). The contained mixed longitudinal cohorts people surveyed 1998, 2000, 2002, 2005, 2008-09, 2011-12 2014. was tested using Mini-Mental State Examination (CMMSE) each wave. unique individual code cohort...
Anti-oxidative stress and inhibition of TGF-β1/Smads signaling cascade are essential therapeutic strategies for diabetic nephropathy (DN). In this study, we aimed to explore the effect combination Ginsenoside Rg1 Astragaloside IV on oxidative in DN rats.Wistar rats were divided into five groups: N group, M group (streptozotocin [STZ], intraperitoneally), G (STZ with Rg1, intragastrically [ig]), A IV, ig) C ig). The levels methane dicarboxylic aldehyde (MDA), catalase (CAT), glutathione...
Abstract Background Intrinsic capacity (IC) is the composite of an individual's physical and mental capacities. However, association between IC trajectories falls hospitalizations remains uncertain. This study aimed to determine among older adults, investigating its with subsequent risk hospitalizations. Methods enrolled 3,902 adults aged ≥65 from National Health Aging Trends Study (NHATS, wave 2015-2019). A bi-factor model was used for repeated measurements five domains generate scores four...
<b><i>Introduction:</i></b> Routine blood factors can be economical and easily accessible candidates for sarcopenia screening monitoring. The associations between routine remain unclear. This study aimed to examine factor based on a nation-wide cohort in China. <b><i>Methods:</i></b> A total of 1,307 participants 17 indices were selected from two waves (year 2011 year 2015) the China Health Retirement Longitudinal Study (CHARLS). diagnosis was...
Background . Many previous studies have shown the potential therapeutic effect of acupuncture for metabolic syndrome (MetS). However, most these were limited by short durations observation and a lack sham as control. We designed randomized controlled trial, used control, evaluated efficacy over 12 weeks treatment follow‐up. Methods/Design The study was multicentre, parallel‐group, randomized, double‐blinded trial. 40 patients randomly assigned to two groups: group (treated with acupuncture)...
Through comparing the literature on randomized controlled trials (RCTs) of acupuncture for anxiety in Chinese and English versions, participants, interventions outcomes therapeutic effect evaluation treatment were analyzed so as to provide references high quality clinical research future.The was retrieved RCTs at home abroad. According principles methods evidence-based medicine, information type research, extracted analyzed.A total 106 valid papers versions collected. In study abroad,...
Background and Purpose: As a first-line clinical drug, thienopyridines still have many unsatisfactory aspects, such as the low bioavailability of clopidogrel high bleeding risk prasugrel. Our team synthesized deuterium clopidogrel(the patent has been obtained in China) to mitigate disadvantages application, including slow onset, greater influence gene polymorphism drug-drug interaction. Experimental Approach: Molecular docking technology was used analyze affinity between P2Y12 receptor; The...
Abstract Stimuli‐responsive hydrogels have the capability to alter their state in response changes physiological signals within application environment, providing distinct benefits drug delivery applications. Here, acidic pH typically found acutely infected wounds can be effectively managed by incorporating a pH‐responsive Ag + loaded system hydrogel, thereby ensuring efficient use and preventing potential toxicity from sudden release of silver ions. The antimicrobial composite hydrogel...
Despite being a first-line clinical drug, thienopyridines have many unsatisfactory aspects, including the low bioavailability of clopidogrel(CLP) and high bleeding risk prasugrel. We synthesized deuterium clopidogrel(D-CL, patented in China) to alleviate deficiency CLP clinical, such as slow onset, greater influence gene polymorphism, frequency drug-drug interaction.Molecular docking was used analyze affinity between D-CL P2Y12 receptor. The levels active metabolites were detected using...
The prevalence of cognitive impairment in western countries decreased past twenty years. It is still unclear how the index changes over time China. study examined Mini-Mental State Examination (MMSE) status 33,043 participants aged at 60 years or older Chinese Longitudinal Healthy Longevity Surveys (CLHLS) 1998, 2000, 2002, 2005, 2008, 2011, and Activities Daily Living (ADLs) 23,537 same age range CLHLS 2011. clinical screening for (CI) was positive when both mental (MI) by MMSE physical...