A5083041488- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Extracellular vesicles in disease
- Burn Injury Management and Outcomes
- Orthodontics and Dentofacial Orthopedics
- Periodontal Regeneration and Treatments
- Facial Rejuvenation and Surgery Techniques
- Pelvic and Acetabular Injuries
- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Skin Protection and Aging
- MicroRNA in disease regulation
- Hydrogels: synthesis, properties, applications
- Temporomandibular Joint Disorders
Shanghai Changzheng Hospital
2022-2024
Second Military Medical University
2024
People's Liberation Army 401 Hospital
2023
Abstract Owing to its constant exposure the external environment and various stimuli, skin ranks among organs most vulnerable manifestations of aging. Preventing delaying aging has become one prominent research subjects in recent years. Mesenchymal stem cells (MSCs) are multipotent derived from mesoderm with high self-renewal ability multilineage differentiation potential. MSC-derived extracellular vesicles (MSC-EVs) nanoscale biological that facilitate intercellular communication regulate...
Loading human umbilical mesenchymal stem cell (hUMSC) derived exosomes onto hydrogel scaffolds is a strategy for rapid wound healing. The clinical application of hindered by low production, and exosome mimetics could be substituted exosomes. Here, the therapeutic effects exosome-loaded hydrogels mimetic-loaded on wounds are evaluated. Our results revealed that promote healing more efficiently than hydrogels. Exosome can proliferation migration dermal fibroblasts (hDF-a) cells in vitro. To...
Exploring the preparation of multifunctional hydrogels from a bionic perspective is an appealing strategy. Here, hydrogel dressing inspired by characteristics porous extracellular matrix produced during Acomys wound healing prepared. These dressings are printed digital light processing printing composed gelatin methacrylate, hyaluronic acid and pretreated platelet-rich plasma (PRP) to shape out triply periodic minimal surface structures, which freeze-dried for long-term storage. mimic...
This work was supported by the Naval Medical University and of Shanghai for Science Technology Joint Projects (2020-RZ04), Innovative Clinical Research Program Changzheng Hospital (2020YLCYJ-Y16), academic project (2022QN073). The authors have no conflicts interest to declare.
Abstract Stimuli‐responsive hydrogels have the capability to alter their state in response changes physiological signals within application environment, providing distinct benefits drug delivery applications. Here, acidic pH typically found acutely infected wounds can be effectively managed by incorporating a pH‐responsive Ag + loaded system hydrogel, thereby ensuring efficient use and preventing potential toxicity from sudden release of silver ions. The antimicrobial composite hydrogel...