A5083801181- Ginseng Biological Effects and Applications
- Chromatography in Natural Products
- Antifungal resistance and susceptibility
- X-ray Diffraction in Crystallography
- Plant biochemistry and biosynthesis
- Crystallization and Solubility Studies
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Plant responses to water stress
- Biochemical effects in animals
- Nonlinear Optical Materials Research
- Phytochemical Studies and Bioactivities
- Biosimilars and Bioanalytical Methods
- Antibiotics Pharmacokinetics and Efficacy
- Plant Stress Responses and Tolerance
- Traditional Chinese Medicine Analysis
- Metal complexes synthesis and properties
- Drug Transport and Resistance Mechanisms
- Protein Interaction Studies and Fluorescence Analysis
- Aldose Reductase and Taurine
- Metabolomics and Mass Spectrometry Studies
- Natural Compounds in Disease Treatment
- HER2/EGFR in Cancer Research
- Reproductive biology and impacts on aquatic species
- Pharmacological Effects of Natural Compounds
Hubei University
2021-2025
Wuhan Polytechnic University
2023-2025
Shijiazhuang Yiling Pharmaceutical (China)
2020-2024
Second Affiliated Hospital of Nanjing Medical University
2024
Xinjiang Agricultural University
2023
CSPC Pharmaceutical Group
2021
China National Pharmaceutical Group Corporation (China)
2021
China Pharmaceutical University
2012-2019
Nanjing Tech University
2014-2018
Nanjing General Hospital of Nanjing Military Command
2017
The present study describes for the first time, a metabolic profile reflecting osteoporosis progression in 364 pre- and postmenopausal Chinese women using GC-MS.
1. A comprehensive method for the simultaneous characterization of xenobiotic compound inhibition nine major CYP enzymes in human liver microsomes was established by using 16 CYP-catalyzed reactions 14 probe substrates with three cocktail incubation sets and a single LC/MS/MS analysis. 2. The subgroups were developed to minimize effects organic solvents, polyunsaturated fatty acids mutual substrate interactions: Group I composed tolbutamide (CYP2C9), S-mephenytoin (CYP2C19), testosterone...
Abstract Transcriptome analysis based on high-throughput sequencing of a cDNA library has been widely applied to functional genomic studies. However, the dependence most RNA techniques constrains their ability detect base modifications RNA, which is an important element for post-transcriptional regulation gene expression. To comprehensively profile N 6 -methyladenosine (m6A) and 5 -methylcytosine (m5C) direct (DRS) using latest Oxford Nanopore Technology was analyze transcriptome six tissues...
The mechanism of asthenozoospermia remains unclear. knowledge the metabolism fatty acids in seminal plasma is important and meaningful for pathological study asthenozoospermia. We present an optimised assay extraction derivatisation followed by GC/MS to analyse metabolites, especially acids, from healthy asthenozoospermic men. Eighty-nine peaks including 17 kinds were analysed identified chromatogram. data using t test, fold change partial least squares discriminant analysis explore...
Abstract Objective: In the present study, we aimed to characterize pathological development of menopausal osteoporosis, as well explore potential biomarkers and metabolic pathways involved in osteoporosis. Methods: Urine samples from 322 female participants categorized by menopause status different bone conditions were collected analyzed based on a gas chromatography–mass spectrometry (GC–MS) approach. Multivariate univariate statistical analyses carried out for urinary metabolomic profile...
Raddeanin A, one of the triterpenoid saponins extracted from Anemone raddeana rhizome Ranunculaceae family, has demonstrated ability to inhibit growth human hepatic and gastric cancer cells. However, effects A on colon cells have not been investigated extensively. The present study aimed examine antiproliferative apoptosis-inducing HCT-116 cell line in vitro, evaluate pharmacokinetic biodistribution properties mice following a single oral administration....
Maize is an important cereal crop worldwide and sensitive to abiotic stresses in fluctuant environments that seriously affect its growth, yield, quality. The small heat shock protein (HSP20) plays a crucial role protecting plants from stress. However, little known about HSP20 maize (ZmHSP20). In this study, 44 ZmHSP20s were identified, which unequally distributed over 10 chromosomes, 6 pairs of tandemly presented. gene structure was highly conserved, with 95% (42) the genes having no more...
Guanfu base A (GFA) is a novel heterocyclic antiarrhythmic drug isolated from <i>Aconitum coreanum</i> (Lèvl.) rapaics and currently in phase IV clinical trial China. However, no study has investigated the influence of GFA on cytochrome P450 (P450) metabolism. We characterized potency specificity CYP2D inhibition based dextromethorphan <i>O</i>-demethylation, CYP2D6 probe substrate activity human, mouse, rat, dog, monkey liver microsomes. In addition, (+)-bufuralol 1′-hydroxylation was used...
A reliable and sensitive HPLC-MS/MS method was firstly developed for the simultaneous determination of hyperoside astragalin in rat plasma. The plasma sample prepared by protein precipitation using 300 μL acetonitrile containing 0.1% formic acid. Chromatographic separation achieved on a C8 column gradient elution program with water 0.05% acid as mobile phase. flow rate 0.2 mL min−1. detection performed triple quadrupole tandem mass spectrometer MRM mode, negative ionization. transitions...
A new meroditerpenoid, igeumone (1), together with 18 known compounds (2-19), were isolated from ethanolic extract of the bark Mayodendron igeum. Their structures determined by analysis spectral data or comparison authentic samples. X-ray crystallographic was employed to unambiguously determine structure 1.
Lotus (Nelumbo nucifera) seeds are widely consumed as functional food or herbal medicine, of which cotyledon (CL) is the main edible part, and lotus plumule (LP) commonly utilized in traditional Chinese medicine. However, few studies have been conducted to investigate chemical components CL LP dry seeds, not mention comparison between wild domesticated varieties. In this study, a targeted metabolomics approach based on Ultra Performance Liquid Chromatography-electrospray ionization-Tandem...
We reported the pharmacokinetic/pharmacodynamic (PK/PD) targets of a biosimilar generic product amphotericin B colloidal dispersion (G-ABCD) againstCandida albicans (MIC 1-2 μg/mL) in rat model invasive candidiasis (IC) to facilitate its precision administration.Single-dose plasma PKs G-ABCD was studied IC following intravenous administration at doses 0.0625-10 mg/kg. Amphotericin concentrations were determined and PK parameters calculated based on plasma. The efficacy evaluated after single...
In this article, we review a recently published article to explore the significance of foot reflexology in modern medical practice. With advancement medicine, are increasingly committed finding specific physiological mechanisms reflexes treat diseases, thereby better proving therapy's effectiveness. It has been reported that can activate cerebral cortex and organs corresponding feet, stimulating blood flow, nutrition nerves through neural endocrine regulation achieve purpose treating...
<title>Abstract</title> Background Plant development and environmental adaptation are intricately regulated by hormones, with auxins playing a pivotal role in these processes. Within the auxin response family, Small Auxin Up-regulated RNAs (SAURs) family holds significant position controlling plant responding to abiotic stress. However, investigations into this tartary buckwheat (<italic>Fagopyrum tataricum</italic>)are still lacking. The whole genome sequence of offers precious opportunity...
ABSTRACT Amphotericin B (AmB) has been a cornerstone in the treatment of invasive fungal infections for over 6 decades. Compared with conventional amphotericin deoxycholate (AmB‐DOC), liposomal comparable efficacy but less nephrotoxicity. The main purpose this study was to investigate reason why similar therapeutic effects lower toxicity and differences distribution humans between AmB‐DOC. To compare AmB‐DOC humans, physiologically based pharmacokinetic (PBPK) model established by bottom‐up...