A5103239092- Plant Reproductive Biology
- Polysaccharides and Plant Cell Walls
- Plant Molecular Biology Research
- Technology Use by Older Adults
- Invertebrate Immune Response Mechanisms
- Insect Resistance and Genetics
- Cancer-related molecular mechanisms research
- Hair Growth and Disorders
- Single-cell and spatial transcriptomics
- RNA and protein synthesis mechanisms
- Zebrafish Biomedical Research Applications
- Studies on Chitinases and Chitosanases
- Aquaculture disease management and microbiota
- Chromosomal and Genetic Variations
- vaccines and immunoinformatics approaches
- Seed and Plant Biochemistry
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Circular RNAs in diseases
- Bioinformatics and Genomic Networks
- Skin Protection and Aging
- Genomics and Rare Diseases
- Plant Genetic and Mutation Studies
- Congenital heart defects research
- Machine Learning in Bioinformatics
First Affiliated Hospital Zhejiang University
2023-2024
Zhejiang University
2008-2024
Wuhan Polytechnic University
2024
Jiangsu University
2023
Heilongjiang University
2021
Pathways Behavioral Services
2017
Abstract Background Cashmere goat is famous for its high-quality fibers. The growth of cashmere in secondary hair follicles exhibits a seasonal pattern arising from circannual changes the natural photoperiod. Although several studies have compared and analyzed differences gene expression between different follicle stages, selection samples these relies on research experience or morphological evidence. Distinguishing cycle according to patterns may help explore regulation mechanisms related...
Clb2 is the major B-type mitotic cyclin required for entry into mitosis in budding yeast Saccharomyces cerevisiae. We showed that accumulation of CLB2 transcripts G2 cells controlled at transcriptional level and identified a 55-bp upstream activating sequence (UAS) containing an Mcm1 binding site as being necessary sufficient cell cycle regulation. Sequences within cycle-regulated UAS were shown to bind vitro, mutation which abolished Mcm1-dependent DNA activity eliminated transcription...
Abstract Aim This study aimed to establish a risk model of hub genes evaluate the prognosis patients with cervical cancer. Methods Based on TCGA and GTEx databases, differentially expressed (DEGs) were screened then analyzed using GO KEGG analyses. The weighted gene co-expression network (WGCNA) was used perform modular analysis DEGs. Univariate Cox regression combined LASSO Cox-pH select prognostic genes. Then, multivariate screen established based evaluated by curve, survival state,...
Abstract Background The endothelial-to-hematopoietic transition (EHT) process during definitive hematopoiesis is highly conserved in vertebrates. Stage-specific expression of transposable elements (TEs) has been detected zebrafish EHT and may promote hematopoietic stem cell (HSC) formation by activating inflammatory signaling. However, little known about how TEs contribute to the human mouse. Results We reconstructed single-cell trajectories mouse resolved dynamic patterns EHT. Most...
RNAi is broadly used to map gene regulatory networks, but the identification of genes that are responsible for observed phenotypes challenging, as small interfering RNAs (siRNAs) simultaneously downregulate intended on targets and many partially complementary off targets. Additionally, scarcity publicly available control datasets hinders development comparative evaluation computational methods analyzing data. Here, we introduce PheLiM (https://github.com/andreariba/PheLiM), a method uses...
Abstract Motivation Quantifying the similarity of human diseases provides guiding insights to discovery micro-scope mechanisms from a macro scale. Previous work demonstrated that better performance can be gained by integrating multiview data sources or applying machine learning techniques. However, designing an efficient framework extract and incorporate information different biological using deep models remains unexplored. Results We present CoGO, Contrastive predict disease based on Gene...
Abstract Human aging is a natural and inevitable biological process that leads to an increased risk of aging-related diseases. Developing anti-aging therapies for diseases requires comprehensive understanding the mechanisms effects longevity from multi-modal multi-faceted perspective. However, most relevant knowledge scattered in biomedical literature, volume which reached 36 million PubMed. Here, we presented HALD, text mining-based human dataset graph all published literature related HALD...
Abstract Hematopoietic stem and progenitor cells generate all the lineages of blood throughout lifespan vertebrates. The emergence hematopoietic is finely tuned by a variety signaling pathways. Previous studies have revealed roles pattern-recognition receptors such as Toll-like RIG-I-like in hematopoiesis. In this study, we find that Nlrc3 , nucleotide-binding domain leucine-rich repeat containing family gene, highly expressed differentiation stages vivo vitro required hematopoiesis...
Hematopoietic stem cells (HSC) reside within specialized microenvironments that undergo dynamic changes throughout development and aging to support HSC function. However, the evolving cell-cell communication networks these niches remain largely unexplored. This study integrates single-cell RNA sequencing datasets systematically characterize niche interactome from ontogeny aging. We reconstructed atlases of at different developmental stages, revealing stage-specific cellular compositions...
Abstract Outbreaks of COVID-19 caused by the novel coronavirus SARS-CoV-2 is still a threat to global human health. In order understand biology and developing drug against COVID-19, vast amount genomic, proteomic, interatomic, clinical data being generated, bioinformatics researchers produced databases, webservers tools gather those publicly available provide an opportunity analyzing such data. However, these resources are scattered need find them from different discretely. To facilitate in...
DNA repeats are abundant in eukaryotic genomes and have been proved to play a vital role genome evolution regulation. A large number of approaches proposed identify various the genome. Some de novo repeat identification tools can efficiently generate sequence repetitive scores based on k-mer counting for detection. However, we noticed that these still be improved terms score calculation, sensitivity segmental duplications detection specificity. Therefore, here, present new computational...
<title>Abstract</title> Background Plant development and environmental adaptation are intricately regulated by hormones, with auxins playing a pivotal role in these processes. Within the auxin response family, Small Auxin Up-regulated RNAs (SAURs) family holds significant position controlling plant responding to abiotic stress. However, investigations into this tartary buckwheat (<italic>Fagopyrum tataricum</italic>)are still lacking. The whole genome sequence of offers precious opportunity...
Background:Fagopyrum tataricum, commonly referred to as tartary buckwheat, is a cultivated medicinal and edible crop renowned for its economic nutritional significance. Following the publication of buckwheat genome, research on functional genomics across various growth environments has gradually begun. Auxin plays crucial role in many life processes. Analyzing expression changes after IAA treatment great significance understanding environmental adaptability. Methods: This study investigated...
Abstract Background The endothelial-to-hematopoietic transition (EHT) process during definitive hematopoiesis in vertebrate is highly conserved. Stage-specific expression of transposable elements (TEs) has been detected zebrafish EHT and may promote hematopoietic stem cell formation by activating inflammatory signaling. However, little known about how TEs contribute to the human mouse. Results We reconstructed single-cell trajectories mouse, resolved dynamic patterns EHT. Most presented a...