A5051442723- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Phytochemical Studies and Bioactivities
- Immune Cell Function and Interaction
- Urinary Tract Infections Management
- Autophagy in Disease and Therapy
- Natural Compounds in Disease Treatment
- Prostate Cancer Treatment and Research
- Zebrafish Biomedical Research Applications
- Chronic Myeloid Leukemia Treatments
- Cell death mechanisms and regulation
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Acute Lymphoblastic Leukemia research
- Calcium signaling and nucleotide metabolism
- Pelvic floor disorders treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical Analysis and Sensing Techniques
- Kidney Stones and Urolithiasis Treatments
- Immune Response and Inflammation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- T-cell and B-cell Immunology
- Platelet Disorders and Treatments
- HIV Research and Treatment
Peking University People's Hospital
2024-2025
Peking University
2024-2025
Tianjin Medical University General Hospital
2022-2024
Shanghai University of Traditional Chinese Medicine
2024
Shanghai Traditional Chinese Medicine Hospital
2024
Tianjin Medical University
2022
Tianjin University of Traditional Chinese Medicine
2022
ORCID
2022
The treatment paradigm of metastatic bladder cancer has remained largely unchanged for decades and the prognosis is extremely poor. This study aimed to evaluate role cystectomy in patients with single-site oligometastatic cancer. Patients distant metastasis at time diagnosis from 2010-2017 were identified Surveillance, Epidemiology, End Results (SEER) database. Cohorts defined by target organ [bone, brain, lung, liver, lymph nodes (DLNs)] then stratified local received [no surgery,...
Cisplatin-based combination chemotherapy alone is currently considered the standard of care for patients with metastatic upper tract urothelial carcinoma (mUTUC). However, less research has been done on efficacy other combinations. In this study, we explored role cytoreductive surgery in mUTUC receiving different types systemic therapy.
The immune-induced aplastic anemia (AA) mouse model has been used for the study of AA. However, there were no uniform conditions establishing a and assessment immunological homeostasis. Our aimed to identify assess AA in immunology pathology.We induced an by combination between sublethal irradiation spleen-thymus lymphocyte infusion. success was identified blood routine tests pathology bone marrow. frequency Th17 Treg cells measured flow cytometry. CD34+ CD41+ detected immunohistochemical...
Objectives: Aplastic anemia (AA) is one of the immune-mediated bone marrow failure disorders caused by multiple factors, including inability CD4 + CD25 regulatory T cells (Tregs) to negatively regulate cytotoxic lymphocytes (CTLs). Dioscin a natural steroid saponin that has similar structure hormones. The purpose this study look into effect on functions CD25+ Tregs in AA mouse model and explore its underlying mechanism.
Aplastic anemia (AA), a disease of bone marrow failure, is caused by CD8+T mediated apoptosis hematopoietic cells. However, traditional immunosuppressive therapy (IST) has severe liver and kidney toxicity even cannot achieve the expected therapeutic effect in some patients.Our study aimed to investigate mechanism dioscin (DNS) for treating AA.Briefly, we established evaluated AA mouse model, DNS positive control drugs were used intervention treatment. After 14 days intervention, femoral...
Abstract Kidney stones and infections significantly affect patients’ health-related quality of life (HRQOL); however, the relationship between urinary tract (UTIs) HRQOL in patients with kidney remains unclear. This study aimed to investigate using validated Chinese version Wisconsin Stone Quality Life questionnaire (C-WISQOL). We prospectively recruited 307 complete C-WISQOL before after stone removal. The participants were diagnosed UTI based on presence pyuria or bacteriuria without...
Objective Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease. The immune imbalance of T cells essential pathological mechanism ITP, more specific, the balance Effector (Teff)/Regulatory cell (Treg) maintains homeostasis. Dendritic (DC), largest antigen-presenting cell, interfere with differentiation pathways and exert regulatory functions. Our team created applied “ NingXueShengBan” (NXSB) decoction. According to our prior studies, we found that NXSB decoction could restore...
<title>Abstract</title> Objective This study aimed to compare the clinical characteristics of urosepsis patients with those having other types sepsis, extract key insights, and identify potential future research avenues. Material Methods Data from 32,971 anonymized records in MIMIC-IV database were analyzed. Among these, 6,141 met inclusion criteria for sepsis. A comparative analysis was conducted, followed by univariate multivariate Cox regression analyses assess in-hospital mortality....
Bladder cancer (BCa) is one of the most common tumors urinary system, imposing a significant societal burden. BCa categorized into muscle-invasive (MIBC) and non-MIBC (NMIBC) types. Radical cystoprostatectomy (RCP) standard treatment for MIBC refractory NMIBC, but it can lead to serious side effects. Incidental prostate (IPCa) frequently found in RCP specimens, with varying incidence rates across ethnic groups, ranging from 7.3% 60%. The clinical significance unclear, disparities tumor...
<title>Abstract</title> Macroautophagy is the mainly regulated form of autophagy that maintains cellular homeostasis and degraded transported cargoes. It initiated by protein kinase complex which initiation receiving two signals pathway mTORC1-AMPK-ULK1 ULK1-PI3K-PI3P. Currently, autolysosomes accumulate during in vitro CD8<sup>+</sup> T cells aging may participate inducing death sensitization senescent cells. Aplastic Anemia a hyperimmune disease mechanism AA subsets imbalance such as...
Abstract Background : Aplastic anemia (AA) is an immune-mediated disease of bone marrow failure owing to activated cytotoxic T lymphocytes (CTLs). CD4+CD25+ regulatory cells (Tregs) could negatively regulate CTLs maintain self-tolerance and avoid excessive immune responses. This study aims investigate the effect Dioscin on functions Tregsin AA mouse model, which were induced by total body irradiation allogeneic lymphocyte infusion. Methods Results The collected CD4+CD25+Tregs randomly...