A5103033755- Transplantation: Methods and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Cardiac Ischemia and Reperfusion
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Viral Infections and Immunology Research
- Advanced MRI Techniques and Applications
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
- Cardiac Arrest and Resuscitation
- Heart Failure Treatment and Management
- Diabetes Treatment and Management
- Cardiovascular Health and Disease Prevention
- Infective Endocarditis Diagnosis and Management
- Frailty in Older Adults
- Congenital Heart Disease Studies
- Polyomavirus and related diseases
- Cardiovascular Effects of Exercise
- Atherosclerosis and Cardiovascular Diseases
- Viral-associated cancers and disorders
St Vincent's Hospital Sydney
2016-2025
Victor Chang Cardiac Research Institute
2015-2024
St Vincent's Hospital
2013-2024
UNSW Sydney
2015-2024
St Vincent's Clinic
2014-2023
St Vincent's Health
2014-2023
St. Vincent's Birmingham
2009-2020
Royal Brompton Hospital
2011-2020
Imperial College London
2011-2020
National Health and Medical Research Council
2016
<h3>Importance</h3>Risk stratification of patients with nonischemic dilated cardiomyopathy is primarily based on left ventricular ejection fraction (LVEF). Superior prognostic factors may improve patient selection for implantable cardioverter-defibrillators (ICDs) and other management decisions.<h3>Objective</h3>To determine whether myocardial fibrosis (detected by late gadolinium enhancement cardiovascular magnetic resonance [LGE-CMR] imaging) an independent incremental predictor mortality...
Cardiovascular magnetic resonance is the gold-standard technique for assessment of ventricular function. Although left volumes and ejection fraction are strong predictors outcome in dilated cardiomyopathy (DCM), there limited data regarding prognostic significance right (RV) systolic dysfunction (RVSD). We investigated whether cardiovascular RV function has value DCM.We prospectively studied 250 consecutive DCM patients with use resonance. RVSD, defined by fraction≤45%, was present 86 (34%)...
T1 mapping is a robust and highly reproducible application to quantify myocardial relaxation of longitudinal magnetisation. Available methods are presently site vendor specific, with variable accuracy precision values between the systems sequences. We assessed transferability method determined reference healthy human myocardium in multicenter setting.
The differential diagnosis of left ventricular (LV) hypertrophy remains challenging in clinical practice, particular, between hypertrophic cardiomyopathy (HCM) and increased LV wall thickness because systemic hypertension. Diffuse myocardial disease is a characteristic feature HCM, an early manifestation sarcomere-gene mutations subexpressed family members (G+P- subjects). This study aimed to investigate whether detecting diffuse by T1 mapping can discriminate HCM versus hypertensive heart...
This study investigated whether T1 mapping by cardiac magnetic resonance (CMR) reflects the clinical evolution of disease in myocarditis and supports its diagnosis independently stages. Acute viral is characterized a range intracellular changes due to replication extracellular spill debris within days infection. Convalescence may be chronic low-grade inflammation leading ventricular remodelling, but also complete resolution myocardial changes. Patients with (N = 165) underwent routine CMR...
Frailty is a clinically recognized syndrome of decreased physiological reserve. The heightened state vulnerability in these patients confers greater risk adverse outcomes after even minor stressors. Our aim was to assess the prevalence and prognostic significance frailty phenotype referred for heart transplantation.Consecutive or on waiting list transplantation from March 2013 underwent assessment. defined as positive response 3 more following 5 components: weak grip strength, slowed walking...
As the inflammatory enzyme myeloperoxidase (MPO) is abundant in ruptured human atherosclerotic plaques, we aimed to investigate role of MPO as a potential diagnostic and therapeutic target for high-risk plaque.We employed tandem stenosis model plaque instability apolipoprotein E gene knockout (Apoe-/-) mice. To test MPO, used Mpo-/-Apoe-/- mice 2-thioxanthine inhibitor AZM198. In vivo activity was assessed by liquid chromatography-tandem mass spectrometry detection 2-chloroethidium...
We recently reported that frailty is independently predictive of increased mortality in patients with advanced heart failure referred for transplantation (HTx). The aim this study was to assess the impact on short-term outcomes after bridge-to-transplant ventricular assist device (BTT-VAD) implantation and/or HTx and determine if reversible these procedures.Between August 2013 2016, 100 126 consecutive underwent assessment using Fried's Frailty Phenotype before surgical intervention: 40 (21...
Heart transplantation from donation after circulatory death (DCD) donors has the potential to substantially increase overall heart transplant activity. The aim of this report is review first 8 y our clinical program at St Vincent’s Hospital Sydney, describe how evolved and impact that changes retrieval protocols have had on posttransplant outcomes. Since 2014, we performed 74 DCD transplants utilizing a direct procurement protocol followed by normothermic machine perfusion. Changes resulted...
Background: Endomyocardial biopsy (EMB) is the gold standard method for surveillance of acute cardiac allograft rejection (ACAR) despite its invasive nature. Cardiovascular magnetic resonance (CMR)–based myocardial tissue characterization allows detection myocarditis. The feasibility CMR-based ACAR-induced myocarditis in first year after heart transplantation currently undescribed. Methods: multiparametric mapping was initially assessed a prospective cross-sectional fashion to establish...
Purpose: To compare myocardial T1 against T2 and T2* in patients with thalassemia major (TM) for iron characterization. Materials Methods: A total of 106 TM (29 ± 10 years; 58 males) were studied on a 1.5 Tesla scanner using dedicated T1, T2*, relaxometry sequences. single mid‐ventricular short axis slice was acquired within breath‐hold. Results: In overload (T2* < 20 ms; n = 52), there linear correlations between (r 0.82; P 0.0), 0.83; 0.0). no (n 54), values scattered significant...
Donation after circulatory death (DCD) provides an alternative pathway to deceased organ transplantation. Although clinical DCD lung, liver, and kidney transplantation are well established, of hearts retrieved from donors has reached translation only recently. Progress been limited by concern regarding the viability hearts. The aim this study was document pathophysiological changes that occur in heart circulation during withdrawal life (WLS) support.In a porcine asphyxia model, we...