A5060738714- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Mechanical Circulatory Support Devices
- Renal Transplantation Outcomes and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Cardiac Ischemia and Reperfusion
- Aortic Disease and Treatment Approaches
- Heart Failure Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Fuel Cells and Related Materials
- Aortic aneurysm repair treatments
- Diabetes Treatment and Management
- Peripheral Artery Disease Management
- Hemodynamic Monitoring and Therapy
- Hip and Femur Fractures
- Nutrition and Health in Aging
- Pancreatic function and diabetes
- Cardiac and Coronary Surgery Techniques
- Frailty in Older Adults
- Ion Transport and Channel Regulation
- Viral Infections and Immunology Research
- Coronary Interventions and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Membrane-based Ion Separation Techniques
Victor Chang Cardiac Research Institute
2021-2024
St Vincent's Hospital Sydney
2020-2024
UNSW Sydney
2021-2024
St Vincent's Clinic
2021-2024
St Vincent's Health
2024
St Vincent's Hospital
2020-2024
Western Sydney University
2021
Macquarie University
2020
Collaborative Research Group
2020
Hôpital Européen Georges-Pompidou
2019
Background: Ischemia–reperfusion injury (IRI) is one of the major risk factors implicated in morbidity and mortality associated with cardiovascular disease. During cardiac ischemia, buildup acidic metabolites results decreased intracellular extracellular pH, which can reach as low 6.0 to 6.5. The resulting tissue acidosis exacerbates ischemic significantly affects function. Methods: We used genetic pharmacologic methods investigate role acid-sensing ion channel 1a (ASIC1a) IRI at cellular...
Heart transplantation from donation after circulatory death (DCD) donors has the potential to substantially increase overall heart transplant activity. The aim of this report is review first 8 y our clinical program at St Vincent’s Hospital Sydney, describe how evolved and impact that changes retrieval protocols have had on posttransplant outcomes. Since 2014, we performed 74 DCD transplants utilizing a direct procurement protocol followed by normothermic machine perfusion. Changes resulted...
Acute renal failure (ARF) is the most common major complication following cardiac surgery for acute aortic syndrome (AAS) and worsens postoperative prognosis. Our aim was to establish a machine learning prediction model ARF occurrence in AAS patients.We included patient data from nine medical centers (n = 1,637) analyzed incidence of risk factors ARF. We used six compare performance four models performed internal validation identify patients who developed The area under curve (AUC) receiver...
In the current era of heart transplantation, machine perfusion strategies are emerging as potential additions to armamentarium a transplant unit. Donation after circulatory death (DCD) donor hearts assessed through normothermic (NMP) has helped expand pool. Hypothermic (HMP) is an alternative strategy traditional static cold storage (SCS) when prolonged ischemic time anticipated in brain dead (BD) donors, this important Australia where long distant procurement vital. study we examine...
Surgical mortality and long-term outcomes are important considerations when determining strategies for multiple reoperations on the aortic valve (AV). With rise of percutaneous valve-in-valve, we sought to evaluate current conventional surgery AV reoperation, focusing first effect number previous interventions with a subsequent analysis risk factors adverse outcomes.From January 2007 December 2016, 316 consecutive patients underwent an open redo operation (replacement) their at single...
Heart transplantation remains the gold standard treatment for end-stage heart failure. With an increasing population and improving medical therapy there is number of patients who would benefit from but are unable to receive one due a shortage suitable donor organs. This ongoing need, significant limitations with traditional cold static storage (CSS), have driven development machine perfusion technology that expanded pool. Machine divided into hypothermic normothermic, both technologies...
Abstract Purpose of Review Recent advances in donor heart preservation have allowed the utilization hearts that would typically be discarded due to prolonged ischemic times or donation via circulatory death pathway. This review will discuss recent including optimization machine perfusion technologies and future strategies potential benefit for transplant outcomes. Findings Improvements organ enabled retrieval were not ideal static cold storage. Machine (normothermic hypothermic) normothermic...
Right ventricular failure after left assist device (LVAD) insertion is associated with significant mortality and morbidity. Mechanical support options include right devices, venoarterial extracorporeal membrane oxygenation (ECMO) venopulmonary artery ECMO, the latter often involving central cannulation. We sought to evaluate feasibility early outcomes of a truly percutaneous (pVPA) ECMO strategy, potential advantage bedside removal once weaned.Data from single tertiary centre were reviewed...
There has been growing interest in heart transplantation from donation after circulatory death (DCD) donors since the first report of distant procurement and successful 3 adult DCD hearts 2014.1 In that initial series, all were explanted arrest, then reanimated, transported using normothermic machine perfusion, a retrieval technique is now known as direct perfusion (DPP). Until then, few reports had limited to cases wherein donor recipient colocated same hospital.2 For next 8 y, 2 pioneering...