A5091151702- Pulmonary Hypertension Research and Treatments
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Renal Transplantation Outcomes and Treatments
- Viral Infections and Immunology Research
- Cardiovascular Issues in Pregnancy
- Cardiac pacing and defibrillation studies
- Organ Transplantation Techniques and Outcomes
- Cardiac Arrest and Resuscitation
- Congenital Heart Disease Studies
- Vascular Anomalies and Treatments
- Hemodynamic Monitoring and Therapy
- Cardiac Valve Diseases and Treatments
- Diabetes Treatment and Management
- Polyomavirus and related diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Liver Disease and Transplantation
- Frailty in Older Adults
- Cytomegalovirus and herpesvirus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
St Vincent's Hospital Sydney
2016-2025
UNSW Sydney
2016-2025
St Vincent's Health
2014-2025
St Vincent's Clinic
2013-2025
Victor Chang Cardiac Research Institute
2007-2024
St Vincent's Hospital
2013-2024
The University of Notre Dame Australia
2022-2023
University of Notre Dame
2023
St Vincent’s Private Hospital Sydney
2020
Coffs Harbour City Council
2017
Background— Although aldosterone, acting via mineralocorticoid receptors, causes left ventricular (LV) hypertrophy in experimental models of high-aldosterone hypertension, little is known about the role aldosterone or receptors mediating adverse remodeling response to chronic pressure overload. Methods and Results— We used receptor–selective antagonist eplerenone (EPL) test transition from failure mice with overload caused by ascending aortic constriction (AAC). One week after AAC, were...
Primary graft failure (PGF) is a devastating complication that occurs in the immediate postoperative period following heart transplantation. It manifests as severe ventricular dysfunction of donor and carries significant mortality morbidity. In last decade, advances pharmacological treatment mechanical circulatory support have improved outlook for transplant recipients who develop this complication. Despite these treatment, PGF still leading cause death first 30 days after today's climate...
We recently reported that frailty is independently predictive of increased mortality in patients with advanced heart failure referred for transplantation (HTx). The aim this study was to assess the impact on short-term outcomes after bridge-to-transplant ventricular assist device (BTT-VAD) implantation and/or HTx and determine if reversible these procedures.Between August 2013 2016, 100 126 consecutive underwent assessment using Fried's Frailty Phenotype before surgical intervention: 40 (21...
Heart transplantation from donation after circulatory death (DCD) donors has the potential to substantially increase overall heart transplant activity. The aim of this report is review first 8 y our clinical program at St Vincent’s Hospital Sydney, describe how evolved and impact that changes retrieval protocols have had on posttransplant outcomes. Since 2014, we performed 74 DCD transplants utilizing a direct procurement protocol followed by normothermic machine perfusion. Changes resulted...
Background: Endomyocardial biopsy (EMB) is the gold standard method for surveillance of acute cardiac allograft rejection (ACAR) despite its invasive nature. Cardiovascular magnetic resonance (CMR)–based myocardial tissue characterization allows detection myocarditis. The feasibility CMR-based ACAR-induced myocarditis in first year after heart transplantation currently undescribed. Methods: multiparametric mapping was initially assessed a prospective cross-sectional fashion to establish...
Early diagnosis of PAH is clinically challenging. Patterns diagnostic delay in Australian and New Zealand populations have not been explored large-scale studies. We aimed to evaluate the magnitude, risk factors survival impact patients.A cohort study patients from PHSANZ Registry diagnosed 2004 2017 was performed. Diagnostic interval time symptom onset right heart catheterization as recorded registry. Factors associated with were analysed a multivariate logistic regression model. Survival...
BACKGROUND Cardiomyopathy associated with thymoma is thought to be a cardiac manifestations of myasthenia gravis (MG). However, there are case reports newly diagnosed presenting cardiomyopathy without MG, and the mechanism remains unclear. The purpose this report explore tachycardia-induced (TIC) as potential for in features MG. CASE REPORT A 31-year-old man presented atrial flutter right bundle branch block severe biventricular heart failure. Echocardiogram revealed left ventricle ejection...
Exercise-based rehabilitation interventions can improve functional outcomes in pulmonary arterial hypertension (PAH), but barriers to participation are common and little is known about the patient-reported experience. This study evaluated patient experience of participating structured, outpatient exercise for PAH, explored how may impact knowledge, attitudes engagement physical activity. A mixed-methods evaluation was conducted alongside a pilot trial (ExPAH). Semi-structured interviews were...
Nonpulsatile left ventricular assist devices (LVADs) are increasingly used for treatment of refractory heart failure. A majority such patients have implanted cardiac devices, namely implantable cardioverter-defibrillators (ICDs) or resynchronization therapy-pacemaker (CRT-P) therapy-defibrillator (CRT-D) devices. However, potential interactions between LVADs and in this category remain unknown.We reviewed case records device logs 15 with ICDs CRT-P CRT-D who subsequently had implantation a...