A5001018887- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Issues in Pregnancy
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Coronary Artery Anomalies
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- Aortic Disease and Treatment Approaches
- Tracheal and airway disorders
- Cardiovascular and Diving-Related Complications
- Renal and Vascular Pathologies
- Heart Failure Treatment and Management
- Mechanical Circulatory Support Devices
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Conditions and Treatments
- Congenital Anomalies and Fetal Surgery
- Cardiovascular and exercise physiology
- Fetal and Pediatric Neurological Disorders
- Vascular anomalies and interventions
- Cardiac electrophysiology and arrhythmias
- Advanced MRI Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
The University of Sydney
2016-2025
Royal Prince Alfred Hospital
2016-2025
Murdoch Children's Research Institute
2019-2024
The Heart Research Institute
2014-2024
The Royal Melbourne Hospital
2022
Australia and New Zealand Dialysis and Transplant Registry
2021
Institute of Cardiology
2020
Royal Children's Hospital
2019
Royal Brompton Hospital
2016-2018
GTx (United States)
2018
Cardiovascular disease is a leading cause of morbidity and mortality in individuals with Down syndrome. Congenital heart the most common cardiovascular condition this group, present up to 50% people syndrome contributing poor outcomes. Additional factors outcomes include pulmonary hypertension; coexistent pulmonary, endocrine, metabolic diseases; risk for atherosclerotic disease. Moreover, disparities care compared general population, which vary across different geographies health systems,...
<h3>Objectives</h3> The peripheral muscle pump is key in promoting cardiac filling during exercise, especially subjects who lack a subpulmonary ventricle (the Fontan circulation). A muscle-wasting syndrome exists acquired heart failure but has not been assessed subjects. We sought to investigate whether adults with the circulation exhibit reduced skeletal mass and/or metabolic abnormalities. <h3>Design and patients</h3> Sixteen New York Heart Association Class I/II (30±2 years) underwent...
Abstract Aims The Fontan operation has resulted in improved survival patients with single‐ventricle congenital heart disease. As a result, there is growing population of teenagers and adults circulation. Many co‐morbidities have been increasingly recognized this due to the unique features Standardization how co‐morbid conditions are defined will help facilitate understanding, consistency interpretability research clinical experience. Unifying common language usage critical precursor step for...
Objective The life expectancy of patients with congenital heart disease (CHD) has significantly improved advances in their paediatric medical care. Mortality patterns are changing as a result. Our study aims to describe survival and causes death contemporary cohort adult CHD. Methods We reviewed 3068 our CHD database (age ≥16 years, seen at least once centre between 2000 2015), documented the number death, via Australia’s National Death Index. Survival mortality were analysed by complexity...
Improved survival has resulted in increasing numbers and complexity of adults with congenital heart disease (ACHD). International guidelines recommend specialized care but many patients are still not managed at dedicated ACHD centres. This study analysed referral sources appropriateness management for referred to our tertiary Centre over the past 3 years.We compared differences between from paediatric/ACHD-trained vs. general adult cardiologists, according Adherence (A) or Non-Adherence (NA)...
Objective Survival of patients with repaired tetralogy Fallot (rToF) into young adulthood is very good. Concerns exist, however, over long-term morbidity and mortality as these subjects reach middle age. We aimed to assess survival the prevalence complications in rToF seen our Adult Congenital Heart Disease (ACHD) service. Methods One hundred sixty-eight consecutive ‘simple rToF’, aged 16 years, followed up at tertiary-level ACHD service Sydney, Australia since 2000, were included....
Background We sought to characterize body composition abnormalities in young patients living with a Fontan circulation and explore potential pathophysiologic associations. Methods Results Twenty-eight were prospectively recruited this cross-sectional study. Participants underwent cardiopulmonary exercise testing, dual-energy X-ray absorptiometry, echocardiography, biochemical assessment. Mean age was 26±7 years. Skeletal muscle mass, estimated by appendicular lean mass index Z score, reduced...
Background Adults with a Fontan circulation tend to have myopenia and elevated adiposity when measured by dual energy x-ray absorptiometry. Bioelectrical impedance analysis is an alternative validated approach assess body composition. We used bioelectrical compare composition between pediatric patients control individuals without heart disease. Methods Results A retrospective chart review identified all aged <22 years who presented for cardiopulmonary exercise testing from April 2019 January...
Abstract Purpose To examine global and health-related quality of life (QOL) among parents individuals with Fontan physiology determine associations sociodemographic, parent child-related health, psychological, relational factors. Methods Parents participating in the Australian New Zealand Registry (ANZFR) QOL Study ( N = 151, Parent Mean age 47.9 ± 10.2 years, range: 31.6–79.6 66% women; child 16.3 8.8, 6.9–48.7 40% female) completed a series validated measures. Health-related was assessed...