A5028926625- Pulmonary Hypertension Research and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Congenital Heart Disease Studies
- Cardiac Imaging and Diagnostics
- Cardiovascular Issues in Pregnancy
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Vascular Anomalies and Treatments
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Coronary Artery Anomalies
- Liver Disease and Transplantation
- Cardiac, Anesthesia and Surgical Outcomes
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac pacing and defibrillation studies
- Cardiovascular Conditions and Treatments
- Cardiac Arrhythmias and Treatments
- Tracheal and airway disorders
- Coronary Interventions and Diagnostics
- Heart rate and cardiovascular health
- Cardiomyopathy and Myosin Studies
The Heart Research Institute
2021-2025
The University of Notre Dame Australia
2016-2025
The University of Sydney
2021-2025
Royal Prince Alfred Hospital
2013-2024
Prince Charles Hospital
2024
University of Notre Dame
2014-2024
University of Glasgow
2024
Torrens University Australia
2022
Royal Darwin Hospital
2019
National Heart Foundation of Australia
2018
<h3>Background</h3> Pulmonary hypertension (PHT) lacks community prevalence and outcome data. <h3>Objective</h3> To characterise minimum ‘indicative’ prevalences mortality data for all forms of PHT in a selected population with an elevated estimated pulmonary artery systolic pressure (ePASP) on echocardiography. <h3>Design</h3> Observational cohort study. <h3>Setting</h3> Residents Armadale the surrounding region Western Australia (population 165 450) referred to our unit transthoracic...
Survival rates for patients with idiopathic pulmonary arterial hypertension (IPAH) have improved the introduction of PAH-specific therapies. However, time between patient-reported onset symptoms and a definitive diagnosis IPAH is consistently delayed. We conducted retrospective, multi-center, descriptive investigation in order to (a) understand what factors contribute persistent diagnostic delays, (b) examine from initial symptom IPAH. Between January 2007 December 2008, we enrolled...
We investigated the sex-based risk of mortality across spectrum left ventricular ejection fraction (LVEF) in a large cohort patients Australia.Quantified levels LVEF from 237 046 women (48.1%) and 256 109 men undergoing first-time, routine echocardiography (2000-2019) were linked to 119 232 deaths (median 5.6 years follow-up). Overall, 17.6% vs. 8.3% had an <50%. An <40% was associated with highest crude cardiovascular-related all-cause at 5 (∼20-30% ∼ 40-50%, respectively). Thereafter,...
Abstract Aims To examine the characteristics/prognostic impact of diastolic dysfunction (DD) according to 2016 American Society Echocardiography (ASE) and European Cardiovascular Imaging (ESCVI) guidelines, individual parameters DD. Methods results Data were derived from a large multicentre mortality-linked echocardiographic registry comprising 436 360 adults with ≥1 function measurement linked 100 597 deaths during 2.2 million person-years follow-up. ASE/European Association (EACVI)...
The mortality risk attributable to moderate aortic stenosis (AS) remains incompletely characterized and has historically been underestimated. We aim evaluate the association between AS all-cause death, comparing it with no/mild (in a general referral population in patients heart failure reduced ejection fraction).
Early diagnosis of PAH is clinically challenging. Patterns diagnostic delay in Australian and New Zealand populations have not been explored large-scale studies. We aimed to evaluate the magnitude, risk factors survival impact patients.A cohort study patients from PHSANZ Registry diagnosed 2004 2017 was performed. Diagnostic interval time symptom onset right heart catheterization as recorded registry. Factors associated with were analysed a multivariate logistic regression model. Survival...
Aims Atrial functional mitral regurgitation (AFMR) is characterised by left atrial and consequent annular dilatation causing regurgitation. AFMR likely to become more common with population ageing, alongside increases in fibrillation heart failure preserved ejection fraction; conditions dilatation. Here, we aim define the prevalence characterise patient survival characteristics of National Echocardiographic Database Australia (NEDA). Methods results 14 004 adults moderate or severe FMR were...
We sought to determine the prevalence of pulmonary complications and especially arterial hypertension (PAH) in an Australian scleroderma population.Between July 2005 June 2007, physicians Western Australia were asked refer patients with specifically for screening. All assessed PAH other respiratory conditions using echocardiography, lung function testing clinical assessments. Right heart catheterization was carried out evidence increased right ventricular systolic pressure.Of 184 analysed,...
OBJECTIVESThis study evaluated the safety, efficacy and clinical performance of tissue-engineered ADAPT® bovine pericardial patch (ABPP) in paediatric patients with a range congenital cardiac anomalies.
Background Current risk stratification tools in pulmonary arterial hypertension (PAH) are limited their discriminatory abilities, partly due to the assumption that prognostic clinical variables have an independent and linear relationship outcomes. We sought demonstrate utility of Bayesian network-based machine learning enhancing predictive ability existing state-of-the-art tool, REVEAL 2.0. Methods derived a tree-augmented naïve Bayes model (titled PHORA) predict 1-year survival PAH patients...
Objective To estimate the population prevalence and treatable burden of severe aortic stenosis (AS) in UK. Methods We adapted a contemporary model profile symptomatic asymptomatic AS Europe North America to number people aged ≥55 years UK who might benefit from surgical valve replacement (SAVR) or transcatheter implantation (TAVI). Results With point 1.48%, we that 291 448 men women had 2019. Of these, 68.3% (199 059, 95% CI 1 77 201 221 355 people) would have been and, therefore, more...
Objective The significance of pulmonary hypertension (PHT) complicating aortic stenosis (AS) is poorly characterised. In a large cohort adults with at least moderate AS, we aimed to describe the prevalence and prognostic importance PHT in such patients. Methods this retrospective study, analysed National Echocardiography Database Australia (data from 2000 2019). Adults an estimated right ventricular systolic pressure (eRVSP), left ejection fraction (LVEF) >50% or greater AS were included...
There is a paucity of data describing the underlying prevalence hypertrophic cardiomyopathy (HCM), primary genetic disorder characterised by progressive left ventricular (LV) hypertrophy and sudden death, from both clinical population perspective.
Background A quantitative estimate of pulmonary artery wedge pressures (PAWP) can be obtained using echocardiography, but including left atrial (LA) volume (ePAWP-LA) in the estimation may misleading. We aimed to derive and validate a new without LA information (ePAWP-NOLA) compare its performance ASE/EACVI algorithms for diastolic dysfunction. Methods ePAWP-NOLA was derived validated separate datasets patients who had undergone right heart catheterization echocardiography. Prognosis...
ObjectiveThis paper aims to identify and describe legislative administrative barriers hospital participation national data linkage for the National Australian Congenital Heart Disease (CHD) Registry.MethodsA narrative review based on CHD Registry experience of establishing participating sites linkages associated with each jurisdiction.ResultsThere were numerous identified that could be overcome additional resources/time, not overcome, reported by jurisdiction.ConclusionsThere is a pressing...
There remains a paucity of data to describe how many people worldwide are affected by pulmonary hypertension (PH), an insidious condition associated with adverse vascular remodelling, progressive heart failure, and death without proactive diagnosis management. We combined on the population rate echocardiographic investigations tricuspid regurgitant velocity (TRV) levels observed within clinical cohort >500 000 people, conservatively estimate number adults mild (TRV 2.5-2.8 m/s), moderate...
Background and objectives Left ventricular diastolic dysfunction (LVDD) is commonly associated with pulmonary hypertension (PHT); however, the factors presence severity of PHT in patients LVDD have not been well characterised. Methods We analysed profiles echo characteristics 16 058 adults preserved left ejection fraction (LVEF, >50%) from National Echocardiography Database Australia. Peak tricuspid regurgitation velocity (TRV) was used to determine PHT. Univariate multivariate analyses...
We investigated long-term mortality associated with changes in left ventricular ejection fraction (LVEF) a large, real-world patient cohort.A total of 117 275 adults (63 ± 16 years, 46% women) had LVEF quantified by the same method ≥6 months apart. This included 17 343 cases (66 15 48% being initially for heart failure (HF). During 3.3 [interquartile range (IQR) 1.7-6.0] years from first to last echocardiogram, median change was -1 (IQR -8 +5) units baseline 62% 54-69%). subsequent 7.6...