A5056316951- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Cardiac Health and Mental Health
- Cardiovascular Effects of Exercise
- Cardiac pacing and defibrillation studies
- Cardiovascular and exercise physiology
- Chemotherapy-induced cardiotoxicity and mitigation
- Atrial Fibrillation Management and Outcomes
- Heart Rate Variability and Autonomic Control
- Congenital Heart Disease Studies
- Helicobacter pylori-related gastroenterology studies
- Cardiac electrophysiology and arrhythmias
- Medication Adherence and Compliance
- Acute Myocardial Infarction Research
- Diabetes Treatment and Management
- Cardiac Valve Diseases and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Disease and Adiposity
- Mobile Health and mHealth Applications
- Congenital heart defects research
- Ultrasound in Clinical Applications
- Venous Thromboembolism Diagnosis and Management
- Blood Pressure and Hypertension Studies
Royal Brisbane and Women's Hospital
2016-2025
The University of Queensland
2016-2025
The Christie NHS Foundation Trust
2023-2025
University of Manchester
1992-2025
National Heart Centre Singapore
2024
British Heart Foundation
1999-2024
National Heart Hospital
2024
Queensland University of Technology
2011-2024
Nepean Hospital
2024
University of the Sunshine Coast
2018-2024
Important progress has been made in the management of Helicobacter pylori infection and this fifth edition Maastricht Consensus Report, key aspects related to clinical role H. were re-evaluated 2015. In V/Florence Conference, 43 experts from 24 countries examined new data five subdivided workshops: (1) Indications/Associations, (2) Diagnosis, (3) Treatment, (4) Prevention/Public Health, (5) Gastric Microbiota. The results individual workshops presented a final consensus voting that included...
Management of Helicobacter pylori infection is evolving and in this 4th edition the Maastricht consensus report aspects related to clinical role H were looked at again 2010. In Maastricht/Florence Consensus Conference 44 experts from 24 countries took active part examined key three subdivided workshops: (1) Indications contraindications for diagnosis treatment, focusing on dyspepsia, non-steroidal anti-inflammatory drugs or aspirin use, gastro-oesophageal reflux disease extraintestinal...
Inherited mutations cause approximately 35 percent of cases dilated cardiomyopathy; however, few genes associated with this disease have been identified. Previously, we located a gene defect that was responsible for autosomal dominant cardiomyopathy and conduction-system on chromosome 1p1–q21, where nuclear-envelope proteins lamin A C are encoded by the LMNA (lamin A/C) gene. Mutations in head or tail domain Emery–Dreifuss muscular dystrophy, childhood-onset characterized joint contractures...
Sudden cardiac death among children and young adults is a devastating event. We performed prospective, population-based, clinical genetic study of sudden adults.
Abstract Randomized clinical trials initially used heart failure (HF) patients with low left ventricular ejection fraction (LVEF) to select study populations high risk enhance statistical power. However, this use of LVEF in has led oversimplification the scientific view a complex syndrome. Descriptive terms such as ‘HFrEF’ (HF reduced LVEF), ‘HFpEF’ preserved and more recently ‘HFmrEF’ mid-range assigned on arbitrary cut-off points, have gradually arisen separate diseases, implying distinct...
To explore temporal trends in antidiabetes drug (ADD) prescribing and intensification patterns, along with glycemic levels comorbidities, possible benefits of novel ADDs delaying the need for insulin initiation patients diagnosed type 2 diabetes.Patients diabetes aged 18-80 years, who initiated any ADD, were selected (n = 1,023,340) from U.S. Centricity Electronic Medical Records. Those second-line ADD after first-line metformin identified (subcohort 1, n 357,482); third-line therapy choices...
Yield of causative variants in hypertrophic cardiomyopathy (HCM) is increased some probands, suggesting different clinical subgroups disease occur. We hypothesized that a negative family history and no sarcomere mutations represent nonfamilial subgroup HCM. sought to determine the prevalence, natural history, potential implications this HCM.Four hundred thirteen unrelated probands with HCM seen specialized center between 2002 2015 genetic testing performed were included retrospective cohort...
BackgroundSteroidal mineralocorticoid receptor antagonists reduce morbidity and mortality among patients with heart failure reduced ejection fraction, but their efficacy in those mildly or preserved fraction has not been established. Data regarding the safety of nonsteroidal antagonist finerenone are needed.MethodsIn this international, double-blind trial, we randomly assigned a left ventricular 40% greater, 1:1 ratio, to receive (at maximum dose 20 mg 40 once daily) matching placebo,...
Aims To describe the baseline characteristics of participants in FINEARTS‐HF trial, contextualized with prior trials including patients heart failure (HF) mildly reduced and preserved ejection fraction (HFmrEF/HFpEF). The trial is comparing effects non‐steroidal mineralocorticoid receptor antagonist finerenone placebo reducing cardiovascular death total worsening HF events HFmrEF/HFpEF. Methods results Patients symptomatic HF, left ventricular (LVEF) ≥40%, estimated glomerular filtration...
Background Coronary heart disease (CHD) remains a leading cause of mortality and disability worldwide. Approximately half the patients who have had prior hospital admission for CHD will recurrent coronary event, with majority these occurring within 12 months. Despite well-established evidence-based therapies, medication non-adherence is highly prevalent reasons are poorly understood. This study evaluates factors influencing adherence to secondary prevention medications in people acute...
Chronic heart failure (CHF) is found in 1.5%–2.0% of Australians. Considered rare people aged less than 45 years, its prevalence increases to over 10% ≥ 65 years. CHF one the most common reasons for hospital admission and general practitioner consultation elderly (≥ 70 years). Common causes are ischaemic disease (present > 50% new cases), hypertension (about two-thirds cases) idiopathic dilated cardiomyopathy (around 5%–10% cases). Diagnosis based on clinical features, chest x-ray objective...
The aims of the study were to describe magnified endoscopic findings in gastric body, correlate these with histology, and evaluate their reproducibility assessment patterns seen.A total 95 consecutive dyspeptic patients underwent upper gastrointestinal endoscopy a magnifying endoscope. endoscopists classified correlated them histological findings. In second part study, 200 images shown five order examine inter- intraobserver variability image assessment.The body categorized into four types:...
Chronic heart failure (CHF) is a complex and lethal clinical syndrome accounting for an increasing number of Australian hospital separations more than 2700 deaths in 2008. In 2006, the National Heart Foundation Australia Cardiac Society New Zealand published Guidelines prevention, detection management chronic Australia, 2006. Results from recently trials provide additional information to be considered CHF. some cases, this new evidence strengthens recommendations previously made 2006...
<h3>Background</h3> Traditional management of families with hypertrophic cardiomyopathy (HCM) involves periodic lifetime clinical screening family members, an approach that does not identify all gene carriers owing to incomplete penetrance and significant heterogeneity. Limitations in availability cost have meant genetic testing is part routine for many HCM families. <h3>Objective</h3> To determine the cost-effectiveness addition management, compared alone. <h3>Methods</h3> A probabilistic...