A5021501440- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
- Congenital Heart Disease Studies
- Cardiovascular Effects of Exercise
- Ion channel regulation and function
- Cardiovascular Function and Risk Factors
- Emergency and Acute Care Studies
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Coronary Artery Anomalies
- Hospital Admissions and Outcomes
- Cardiac Structural Anomalies and Repair
- Acute Myocardial Infarction Research
- Congenital heart defects research
- Health Systems, Economic Evaluations, Quality of Life
- Liver Disease Diagnosis and Treatment
- Sepsis Diagnosis and Treatment
- ECG Monitoring and Analysis
- Cardiac, Anesthesia and Surgical Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Respiratory Support and Mechanisms
- Primary Care and Health Outcomes
- Diabetes Treatment and Management
University of Chicago
2016-2025
The University of Melbourne
2015-2024
Murdoch Children's Research Institute
2014-2024
Royal Children's Hospital
2015-2024
University of Chicago Medical Center
2010-2024
NHS Greater Glasgow and Clyde
2024
American College of Physicians
2020-2024
Emory University
2024
National Institute of Research in Tuberculosis
2022
Mongolian University of Life Sciences
2022
Sudden cardiac death among children and young adults is a devastating event. We performed prospective, population-based, clinical genetic study of sudden adults.
The incidence and age distribution of primary cardiomyopathy in children are not well defined. We undertook a population-based, retrospective cohort study Australia to document the epidemiology childhood cardiomyopathy.
Gut microflora-mucosal interactions may be involved in the pathogenesis of irritable bowel syndrome (IBS).To investigate efficacy a novel prebiotic trans-galactooligosaccharide changing colonic microflora and improve symptoms IBS sufferers.In all, 44 patients with Rome II positive completed 12-week single centre parallel crossover controlled clinical trial. Patients were randomized to receive either 3.5 g/d prebiotic, 7 or placebo. monitored weekly scored according 7-point Likert scale....
Mervyn Singer, MD, FRCP; Clifford S. Deutschman, MS; Christopher Warren Seymour, MSc; Manu Shankar-Hari, MSc, FFICM; Djillali Annane, PhD; Michael Bauer, MD; Rinaldo Bellomo, Gordon R. Bernard, Jean-Daniel Chiche, Craig M. Coopersmith, Richard Hotchkiss, Mitchell Levy, John C. Marshall, Greg Martin, Steven Opal, D. Rubenfeld, Tom van der Poll, Jean-Louis Vincent, Derek Angus, MPH
Background— Despite considerable mortality, population-based prognostic factors for childhood dilated cardiomyopathy are lacking. Methods and Results— A cohort study was undertaken of all children in Australia who presented with at age 0 to 10 years between January 1, 1987, December 31, 1996. single cardiologist analyzed cardiac investigations, a pathologist histopathological material. There were 184 subjects cardiomyopathy. Positive viral identification or lymphocytic myocarditis found 30...
Background— Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic disorder causing life-threatening arrhythmias whenever sympathetic activity increases. β-Βlockers are the mainstay of therapy; when they fail, implantable cardioverter-defibrillators (ICDs) used but often cause multiple shocks. Preliminary results with flecainide appear encouraging. We proposed left cardiac denervation (LCSD) as useful additional therapy, evidence remains anecdotal. Methods and Results—...
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This JAMA Guidelines Synopsis summarizes the American Thoracic Society (ATS)/Infectious Diseases of America (IDSA) 2019 recommendations on diagnosis and treatment adults with community-acquired pneumonia.
The effect of osteopathic manual therapy (i.e., spinal manipulation) in patients with chronic and subchronic back pain is largely unknown, its use such controversial. Nevertheless, a frequently used method treatment this group patients.
Background— Population-based studies have provided insight into the natural history of adult hypertrophic cardiomyopathy, but comparable information for affected children is lacking. Methods and Results— All Australian who presented with primary cardiomyopathy at 0 to 10 years age between January 1, 1987, December 31, 1996, were enrolled in a longitudinal cohort study. A single cardiologist reviewed serial cardiac investigations on each subject. total 80 subjects identified. An underlying...
Background— Existing studies of childhood dilated cardiomyopathy deal mainly with early survival. This population-based study examines long-term outcomes for children cardiomyopathy. Methods and Results— The diagnosis was based on clinical, echocardiographic, pathological findings. primary end point included time to the combined outcome death or cardiac transplantation. There were 175 patients 0 <10 years age at diagnosis. Survival free from transplantation 74% (95% confidence interval,...
Abstract BACKGROUND: Communication and coordination with primary care physicians (PCPs) is recommended to ensure safe transitions for hospitalized older patients. Understanding patient experiences of problems after discharge can help clinical teams design more patient‐centered transitions. OBJECTIVE: To report patients' hospital investigate whether PCPs were aware their hospitalization. DESIGN: Prospective mixed methods study. SETTING: Single academic medical center. PATIENTS: Hospitalized...
Background: Late survival and symptomatic status of children with hypertrophic cardiomyopathy have not been well defined. We examined long-term outcomes for pediatric cardiomyopathy. Methods: The National Australian Childhood Cardiomyopathy Study is a longitudinal population-based cohort study (0–10 years age) diagnosed between 1987 1996. primary end point was time to death or cardiac transplantation. Results: There were 80 patients cardiomyopathy, median age at diagnosis 0.48 (interquartile...
This Clinical Guideline Synopsis discusses updated guidelines from the Centers for Disease Control and Prevention on prevention, diagnosis, management of sexually transmitted infections, specifically gonorrhea, chlamydia, Mycoplasma genitalium, syphilis.
<h3>Importance</h3> Patients with catecholaminergic polymorphic ventricular tachycardia (CPVT) may experience life-threatening arrhythmic events (LTAEs) despite β-blocker treatment. Further complicating management, the role of implantable cardioverter defibrillator (ICD) in CPVT is debated. <h3>Objective</h3> To investigate long-term outcomes patients with<i>RYR2</i>CPVT treated β-blockers only and cost to benefit ratio ICD. <h3>Design, Settings, Participants</h3> This prospective cohort...
This JAMA Clinical Guidelines Synopsis summarizes the American Association of Endocrinology’s 2022 clinical practice guideline for diagnosis and management nonalcoholic fatty liver disease.