A5009649796- Gut microbiota and health
- Microbial Metabolites in Food Biotechnology
- Probiotics and Fermented Foods
- Digestive system and related health
- Gastrointestinal motility and disorders
- Infant Nutrition and Health
- Diet and metabolism studies
- Food composition and properties
- Infant Health and Development
- Diet, Metabolism, and Disease
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Therapeutic Uses of Natural Elements
- Viral gastroenteritis research and epidemiology
- Pediatric health and respiratory diseases
- Child Nutrition and Water Access
- Clostridium difficile and Clostridium perfringens research
- Child Nutrition and Feeding Issues
- Nutrition, Genetics, and Disease
- Cancer Research and Treatments
- Medicinal Plants and Bioactive Compounds
- Tea Polyphenols and Effects
- Helicobacter pylori-related gastroenterology studies
- Biochemical Analysis and Sensing Techniques
- Asthma and respiratory diseases
- Congenital gastrointestinal and neural anomalies
University of Reading
2004-2021
Clasado BioSciences (United Kingdom)
2008-2018
University of Southampton
2016
Nottingham Trent University
2016
University of Nottingham
2016
Cambridge University Press
2016
New York University Press
2016
Food & Nutrition
2013
Quadram Institute
2008
Gut microflora-mucosal interactions may be involved in the pathogenesis of irritable bowel syndrome (IBS).To investigate efficacy a novel prebiotic trans-galactooligosaccharide changing colonic microflora and improve symptoms IBS sufferers.In all, 44 patients with Rome II positive completed 12-week single centre parallel crossover controlled clinical trial. Patients were randomized to receive either 3.5 g/d prebiotic, 7 or placebo. monitored weekly scored according 7-point Likert scale....
We have investigated the bacterial-dependent metabolism of ( − )-epicatechin and (+)-catechin using a pH-controlled, stirred, batch-culture fermentation system reflective distal region human large intestine. Incubation or (150 mg/l 1000 mg/l) with faecal bacteria, led to generation 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone, 5-phenyl-γ-valerolactone phenylpropionic acid. However, formation these metabolites from required its initial conversion (+)-epicatechin. The both flavanols occurred in...
Different dietary approaches, such as gluten and casein free diets, or the use of probiotics prebiotics have been suggested in autistic spectrum disorders order to reduce gastrointestinal (GI) disturbances. GI symptoms are particular interest this population due prevalence correlation with severity behavioural traits. Nowadays, there is lack strong evidence about effect interventions on these problems, particularly prebiotics. Therefore, we assessed impact exclusion diets a 6-week Bimuno®...
It is recognised that ageing induces various changes to the human colonic microbiota. Most relevant a reduction in bifidobacteria, which health-positive genus. Prebiotics, such as galacto-oligosaccharides (GOS), are dietary ingredients selectively fortify beneficial gut microbial groups. Therefore, they have potential reverse age-related decline bifidobacteria and modulate associated health parameters. We assessed effect of GOS mixture (Bimuno (B-GOS)) on microbiota, markers immune function...
Children with autism spectrum disorders (ASD) often suffer gastrointestinal problems consistent imbalances in the gut microbial population. Treatment antibiotics or pro/prebiotics has been postulated to regulate microbiota and improve symptoms, but there is a lack of evidence for such approaches, especially prebiotics. This study assessed influence prebiotic galactooligosaccharide (B-GOS) on ecology metabolic function using faecal samples from autistic non-autistic children an vitro model...
Prebiotics are nondigestible carbohydrates that beneficially affect the host by selectively stimulating growth and/or activity of one, or a limited number of, bacteria present in colon. The selected genera should have capacity to improve health (e.g. Bifidobacterium, Lactobacillus). To help identify preferred types, for inclusion into diet, quantitative equation [measure prebiotic effect (MPE)] is suggested. This will evaluate, vitro, fermentation dietary and compare their effect. Although...
Prebiotics are nondigestible carbohydrates that beneficially affect the host by selectively stimulating growth and/or activity of one, or a limited number of, bacteria present in colon. The selected genera should have capacity to improve health (e.g. Bifidobacterium, Lactobacillus). To help identify preferred types, for inclusion into diet, quantitative equation [measure prebiotic effect (MPE)] is suggested. This will evaluate, vitro, fermentation dietary and compare their effect. Although...
The gut microbiota plays an important role in the development of immune and gastrointestinal systems infants. In present study, we investigated whether increased salmon consumption during pregnancy, maternal weight gain pregnancy or mode infant feeding alter markers defence inflammation. Women ( n 123) who rarely ate oily fish were randomly assigned to continue consuming their habitual diet consume two 150 g portions farmed per week from 20 weeks delivery. Faecal samples collected mothers...
Abstract Background Prebiotics exert beneficial effects upon gastrointestinal (GI) environment, but this is not always accompanied with a positive effect on GI symptoms. B‐GOS® prebiotic high selectivity toward bifidobacteria and variety of other in humans. Here, we investigated its symptoms adults who suffer bloating, abdominal pain, flatulence. Methods In double‐blind, placebo‐controlled, crossover study, 83 subjects from the general population presented during screening period had...
Prebiotics have been shown to reduce abdominal symptoms in patients with functional gut disorders, despite that they are fermented by colonic bacteria and may induce gas-related symptoms.To investigate changes the metabolic activity of microbiota induced a recognised prebiotic.Healthy subjects (n = 20) were given prebiotic (2.8 g/day HOST-G904, HOST Therabiomics, Jersey, Channel Islands) for 3 weeks. During 3-day periods immediately before, at beginning end administration put on standard...
Gut microbes have a substantial influence on systemic immune function and allergic sensitisation. Manipulation of the gut microbiome through prebiotics may provide potential strategy to immunopathology asthma. This study investigated effects prebiotic Bimuno-galactooligosaccharide (B-GOS) supplementation hyperpnoea-induced bronchoconstriction (HIB), surrogate for exercise-induced bronchoconstriction, airway inflammation. A total ten adults with asthma HIB eight controls without were...
Abstract Prebiotic oligosaccharides have the ability to generate important changes in gut microbiota composition that may confer health benefits host. Reducing impurities prebiotic mixtures could expand their applications food industries and improve selectivity effect on potential beneficial bacteria such as bifidobacteria lactobacilli. This study aimed determine vitro fermentation properties of a 65 % galacto-oligosaccharide (GOS) content Bimuno ® GOS (B-GOS) metabolites. Fermentation B-GOS...
Abstract Background We have shown that a galactooligosaccharide prebiotic administration ( HOST ‐G904) initially increased intestinal gas production and this increase declined back to baseline after 2 week administration. Our aim was determine the mechanism of microbiota adaptation; i.e., whether net reduction is due decreased overall or consumption. Methods In 10 healthy subjects, intraluminal disposal measured before, at beginning ‐G904 Anal collected for 4 hour probe meal. Paired studies...
A three-stage continuous fermentative colonic model system was used to monitor in vitro the effect of different orange juice formulations on prebiotic activity. Three juices with and without Bimuno, a GOS mixture containing galactooligosaccharides (B-GOS) were assessed terms their ability induce bifidogenic microbiota. The recipe development based incorporating 2.75g B-GOS into 250 ml serving (65°Brix concentrate juice). Alongside production juice, control – any additional Bimuno positive...
The complex interactions between intestinal microbiota and metabolic disorders are well-documented, with implications for glucose metabolism, energy expenditure, permeability. Prebiotics induce beneficial changes in gut composition prediabetes, while postbiotics can enhance barrier function, complementing each other to improve metabolism insulin sensitivity. This study investigated the effects of a 12-week dietary fibre (DF) supplement on health, diet. contained konjac glucomannan (KGM),...
Prebiotics are dietary carbohydrates that favourably modulate the gut microbiota. The aims of present study were to develop a functional prebiotic bread using Bimuno®, (galactooligosaccharide (B-GOS) mixture), for modulation microbiota in vitro individuals at risk metabolic syndrome. A control bread, (no added prebiotic) and positive (containing equivalent carbohydrate B-GOS bread) also developed. 3-stage continuous colonic model was used assess functionality breads. Bacteria quantified by...