A5080362476- Gut microbiota and health
- Inflammatory Bowel Disease
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Diverticular Disease and Complications
- Microscopic Colitis
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Testicular diseases and treatments
- Autoimmune and Inflammatory Disorders
- Colorectal Cancer Surgical Treatments
- Sexual Differentiation and Disorders
- Stress Responses and Cortisol
- Microbial Community Ecology and Physiology
- Machine Learning in Healthcare
- Ovarian cancer diagnosis and treatment
- Women's cancer prevention and management
- Healthcare during COVID-19 Pandemic
- Thyroid Cancer Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Liver Disease and Transplantation
- Genomics and Phylogenetic Studies
APC Microbiome Institute
2020-2023
University College Cork
2020-2023
Vall d'Hebron Institut de Recerca
2016-2020
Fundación Chile
2018
Clinica Santa Maria
2018
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2017
Universitat Autònoma de Barcelona
2017
<h3>Objective</h3> A decade of microbiome studies has linked IBD to an alteration in the gut microbial community genetically predisposed subjects. However, existing profiles dysbiosis adult patients are inconsistent among published studies, and did not allow identification signatures for CD UC. Here, we aimed compare faecal with having UC non-IBD subjects a longitudinal study. <h3>Design</h3> We analysed cohort 2045 samples from four countries (Spain, Belgium, UK Germany), applied 16S rRNA...
Abstract To date, meta-omic approaches use high-throughput sequencing technologies, which produce a huge amount of data, thus challenging modern computers. Here we present MetaTrans, an efficient open-source pipeline to analyze the structure and functions active microbial communities using power multi-threading The is designed perform two types RNA-Seq analyses: taxonomic gene expression. It performs quality-control assessment, rRNA removal, maps reads against functional databases also...
Social anxiety disorder (SAD) is a crippling psychiatric characterized by intense fear or in social situations and their avoidance. However, the underlying biology of SAD unclear better treatments are needed. Recently, gut microbiota has emerged as key regulator both brain behaviour, especially those related to function. Moreover, increasing data supports role for immune function oxytocin signalling responses. To investigate whether plays causal modulating behaviours relevant SAD, we...
The progression of cirrhosis is associated with alterations in the composition gut microbiome. To assess microbial translocation, we compared serum patients and without ascites characterized ascitic fluid microbiome using 16S rDNA high-throughput sequencing data. A complex specific community was detected but barely detectable healthy controls. presented higher levels lipopolysaccharide binding protein, a marker diversity relative abundance Clostridiales an unknown genus belonging to...
Autism spectrum disorder (ASD) is a neurodevelopmental characterised by deficits in social behaviour, increased repetitive anxiety and gastrointestinal symptoms. The aetiology of ASD complex involves an interplay genetic environmental factors. Emerging pre-clinical clinical studies have documented potential role for the gut microbiome ASD, consequently, microbiota represents target development novel therapeutics this disorder. In study, we investigate efficacy live biotherapeutic strain,...
Abstract Background and Aims Intestinal microbiota dysbiosis is implicated in Crohn’s disease [CD] may play an important role triggering postoperative recurrence [POR]. We prospectively studied faecal mucosal microbial recolonisation following ileocaecal resection to identify the predictive value of recurrence-related microbiota. Methods Mucosal and/or samples from 121 CD patients undergoing were collected at predefined time points before after surgery. Ileal biopsies 39 healthy controls....
Targeting the gut microbiome as an effective therapeutic strategy for psychological disorders has shown promise in recent years. Variation composition of microbiota and restoration a stable using targeted interventions (psychobiotics) including Bifidobacteria have pre-clinical studies, but more human data is required on potential health benefits these live microorganisms. Bifidobacterium Bif. longum 1714 been to dampen effects acute stress humans. However, its over period prolonged not...
Prebiotics have been shown to reduce abdominal symptoms in patients with functional gut disorders, despite that they are fermented by colonic bacteria and may induce gas-related symptoms.To investigate changes the metabolic activity of microbiota induced a recognised prebiotic.Healthy subjects (n = 20) were given prebiotic (2.8 g/day HOST-G904, HOST Therabiomics, Jersey, Channel Islands) for 3 weeks. During 3-day periods immediately before, at beginning end administration put on standard...
BackgroundThe remission of Crohn's disease (CD) can be accomplished by faecal microbiota transplantation (FMT). However, this procedure has a low success rate, which could attributed to mis-communication between recipient intestinal mucosa and donor microbiota.MethodsHere we used human explant tissue model an in vivo mouse examine changes upon contact with suspension (FS) obtained from healthy donor. CD patients provided resected inflamed non-inflamed mucosal tissues, whereas control colonic...
The gut microbiota is a key factor in the maintenance of physiological homeostasis and immunity. Correlational studies have demonstrated that alterations composition been associated with addiction. Moreover, animal confirmed link between reward social processes, which may be shaped by thus influencing neurodevelopment programming behaviors across diverse species. However, whether there an interaction processes context drug remains unclear. To this end, we explored influence regulating...
Background: Dysbiosis of the intestinal microbiota is implicated in Crohn's disease (CD) and may play an important role triggering postoperative recurrence (POR). We hypothesized that fecal microbial recolonization process after ileocecal resection differs between patients developing remaining remission, further aimed to identify other factors influencing composition. Methods: Fecal samples from 54 CD undergoing were prospectively collected before surgery at month 1, 3 6 surgery. POR -...
Background: Mucosa-associated bacteria are believed to play a more prominent role in the pathogenesis of Crohn's disease (CD) as they closer contact gut immune system. Our aim was study temporal changes microbiota CD patients undergoing ileocecal resection and identify predictive value recurrence-related microbiota. Methods: A total 204 samples from were prospectively collected: biopsies taken resected intestine (histologically inflamed (N=63) non-inflamed ileum (N=56)) neoterminal (N=85)...
We report a 72-years-old male patient with extensive differentiated thyroid cancer (DTC), who required tracheostomy and gastrostomy. Considering his clinical condition, risk of aspiration management the ostomies, radioiodine (131I) was administered intravenously, using recombinant human thyrotropin (rhTSH) levothyroxine. The procedure successful, both clinically in terms radioprotection.