A5069464036- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Viral Infections and Immunology Research
- Cardiomyopathy and Myosin Studies
- Cardiovascular Disease and Adiposity
- Coronary Interventions and Diagnostics
- Long-Term Effects of COVID-19
- Cardiovascular Effects of Exercise
- COVID-19 Clinical Research Studies
- Cardiac electrophysiology and arrhythmias
- Systemic Lupus Erythematosus Research
- Cardiovascular Health and Disease Prevention
- Cardiac Valve Diseases and Treatments
- HIV-related health complications and treatments
- Cardiac Fibrosis and Remodeling
- Atherosclerosis and Cardiovascular Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Acute Myocardial Infarction Research
- Infective Endocarditis Diagnosis and Management
- Pulmonary Hypertension Research and Treatments
- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging Techniques and Applications
- Transplantation: Methods and Outcomes
Goethe University Frankfurt
2016-2025
German Centre for Cardiovascular Research
2019-2025
Cardio-Pulmonary Institute
2025
University Hospital Frankfurt
2015-2024
National Heart Institute
2022
Cardiovascular Center Frankfurt
2019
Guy's Hospital
2016-2018
Guy's and St Thomas' NHS Foundation Trust
2011-2018
Goethe Institut
2018
King's College London
2010-2017
Coronavirus disease 2019 (COVID-19) continues to cause considerable morbidity and mortality worldwide. Case reports of hospitalized patients suggest that COVID-19 prominently affects the cardiovascular system, but overall impact remains unknown.To evaluate presence myocardial injury in unselected recently recovered from illness.In this prospective observational cohort study, 100 illness were identified University Hospital Frankfurt Registry between April June 2020.Recent recovery severe...
In patients with stable angina, two strategies are often used to guide revascularization: one involves myocardial-perfusion cardiovascular magnetic resonance imaging (MRI), and the other invasive angiography measurement of fractional flow reserve (FFR). Whether a MRI-based strategy is noninferior an FFR-based respect major adverse cardiac events has not been established.We performed unblinded, multicenter, clinical-effectiveness trial by randomly assigning 918 typical angina either or more...
T1 mapping is a robust and highly reproducible application to quantify myocardial relaxation of longitudinal magnetisation. Available methods are presently site vendor specific, with variable accuracy precision values between the systems sequences. We assessed transferability method determined reference healthy human myocardium in multicenter setting.
The differential diagnosis of left ventricular (LV) hypertrophy remains challenging in clinical practice, particular, between hypertrophic cardiomyopathy (HCM) and increased LV wall thickness because systemic hypertension. Diffuse myocardial disease is a characteristic feature HCM, an early manifestation sarcomere-gene mutations subexpressed family members (G+P- subjects). This study aimed to investigate whether detecting diffuse by T1 mapping can discriminate HCM versus hypertensive heart...
Background— After myocardial ischemia, extracellular matrix (ECM) deposition occurs at the site of focal injury and border region. Methods Results— We have applied a novel proteomic method for analysis ECM in cardiovascular tissues to porcine model ischemia/reperfusion injury. proteins were sequentially extracted identified by liquid chromatography tandem mass spectrometry. For first time, such as cartilage intermediate layer protein 1, matrilin-4, adipocyte enhancer binding collagen...
This study investigated whether T1 mapping by cardiac magnetic resonance (CMR) reflects the clinical evolution of disease in myocarditis and supports its diagnosis independently stages. Acute viral is characterized a range intracellular changes due to replication extracellular spill debris within days infection. Convalescence may be chronic low-grade inflammation leading ventricular remodelling, but also complete resolution myocardial changes. Patients with (N = 165) underwent routine CMR...
Cardiac symptoms are increasingly recognized as late complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in previously well individuals with mild initial illness, but the underlying pathophysiology leading to long-term cardiac remains unclear. In this study, we conducted serial assessments a selected population Coronavirus Disease 2019 (COVID-19) no previous disease or notable comorbidities by measuring blood biomarkers heart injury dysfunction and...
Hematopoietic mutations in epigenetic regulators like DNA methyltransferase 3 alpha (DNMT3A), play a pivotal role driving clonal hematopoiesis of indeterminate potential (CHIP), and are associated with unfavorable outcomes patients suffering from heart failure (HF). However, the precise interactions between CHIP-mutated cells other cardiac cell types remain unknown. Here, we identify fibroblasts as partners monocytes. We used combined transcriptomic data derived peripheral blood mononuclear...
Increased systemic inflammation has been linked to myocardial dysfunction and heart failure in patients with lupus erythematosus (SLE). Accurate detection of early changes may be able guide preventive intervention. We investigated whether multiparametric imaging by cardiovascular magnetic resonance can detect differences between controls asymptomatic SLE patients.A total 33 predominantly female (mean age, 40±9 years) underwent for routine assessment perfusion, function, late gadolinium...
Background: Cardiopulmonary bypass (CPB) is associated with a significant risk of postoperative renal dysfunction. We studied the utility novel biomarker in predicting acute kidney injury (AKI) adult patients undergoing cardiac surgery. Methods and Results: Blood urine were obtained from 50 CPB-requiring Patients divided into group A (n = 41) normal creatinine pre-bypass post-bypass B 9) who developed an increase serum >0.5 mg/dL within first 48 hours post CPB. Plasma urinary neutrophil...
T1 imaging based on pixel-wise quantification of longitudinal relaxation has the potential to differentiate between normal and abnormal myocardium. The accuracy measurement not been established nor systematically tested in presence health disease.
Purpose To determine whether quantitative tissue characterization with T1 and T2 mapping supports recognition of myocardial involvement in patients systemic sarcoidosis. Materials Methods Fifty-three consecutive a biopsy-proven extracardiac diagnosis sarcoidosis (21 men; median age, 45 years; interquartile range, 22 years) 36 normotensive previously healthy control subjects (14 43 18 underwent cardiovascular magnetic resonance imaging, which was performed to assess cardiac function late...
Background: Endomyocardial biopsy (EMB) is the gold standard method for surveillance of acute cardiac allograft rejection (ACAR) despite its invasive nature. Cardiovascular magnetic resonance (CMR)–based myocardial tissue characterization allows detection myocarditis. The feasibility CMR-based ACAR-induced myocarditis in first year after heart transplantation currently undescribed. Methods: multiparametric mapping was initially assessed a prospective cross-sectional fashion to establish...