A5072328509- Viral Infections and Immunology Research
- Cardiomyopathy and Myosin Studies
- Eosinophilic Disorders and Syndromes
- Parvovirus B19 Infection Studies
- Cardiac Fibrosis and Remodeling
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Pericarditis and Cardiac Tamponade
- Cardiac Imaging and Diagnostics
- SARS-CoV-2 and COVID-19 Research
- Cytomegalovirus and herpesvirus research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- COVID-19 Clinical Research Studies
- Infective Endocarditis Diagnosis and Management
- Heart Failure Treatment and Management
- Sarcoidosis and Beryllium Toxicity Research
- Virus-based gene therapy research
- Cardiac Valve Diseases and Treatments
- Whipple's Disease and Interleukins
- Aortic Thrombus and Embolism
- Systemic Lupus Erythematosus Research
- Long-Term Effects of COVID-19
- RNA regulation and disease
- Ultrasound in Clinical Applications
German Centre for Cardiovascular Research
2015-2025
CS Diagnostics
2015-2025
Charité - Universitätsmedizin Berlin
2015-2024
Deutsches Herzzentrum der Charité
2023-2024
LMU Klinikum
2020-2023
Ludwig-Maximilians-Universität München
2008-2023
Freie Universität Berlin
2003-2022
Humboldt-Universität zu Berlin
2021-2022
Institut Kardiale Diagnostik und Therapie
2014-2020
Innsbruck Medical University
2019
Coronavirus disease 2019 (COVID-19) continues to cause considerable morbidity and mortality worldwide. Case reports of hospitalized patients suggest that COVID-19 prominently affects the cardiovascular system, but overall impact remains unknown.To evaluate presence myocardial injury in unselected recently recovered from illness.In this prospective observational cohort study, 100 illness were identified University Hospital Frankfurt Registry between April June 2020.Recent recovery severe...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be documented in various tissues, but the frequency of cardiac involvement as well possible consequences are unknown.To evaluate presence SARS-CoV-2 myocardial tissue from autopsy cases and to document a response that infection.This cohort study used data consecutive Germany between April 8 18, 2020. All patients had tested positive for pharyngeal swab tests.Patients who died disease 2019.Incidence positivity CD3+, CD45+, CD68+...
Background— The pathophysiology of heart failure with normal ejection fraction (HFNEF) is still under discussion. Here we report the influence cardiac inflammation on extracellular matrix (ECM) remodeling in patients HFNEF. Methods and Results— We investigated left ventricular systolic diastolic function 20 HFNEF 8 control by conductance catheter methods echocardiography. Endomyocardial biopsy samples were also obtained, ECM proteins as well inflammatory cells investigated. Primary human...
Abstract Aims Since December 2019, the novel coronavirus SARS‐CoV‐2 has spread rapidly throughout China and keeps world in suspense. Cardiovascular complications with myocarditis embolism due to COVID‐19 have been reported. genome detection heart muscle not demonstrated so far, underlying pathophysiological mechanisms remain be investigated. Methods results Endomyocardial biopsies (EMBs) of 104 patients (mean age: 57.90 ± 16.37 years; left ventricular ejection fraction: 33.7 14.6%, sex: n =...
Inflammation is a key driver of atherosclerosis and myocardial infarction (MI), beyond proteins microRNAs (miRs), long noncoding RNAs (lncRNAs) have been implicated in inflammation control. To obtain further information on the possible role lncRNAs context atherosclerosis, we obtained comprehensive transcriptome maps circulating immune cells (peripheral blood mononuclear cells, PBMCs) early onset MI patients. One lncRNA significantly suppressed post-MI patients was investigated murine...
Myocarditis in response to COVID-19 vaccination has been reported since early 2021. In particular, young male individuals have identified exhibit an increased risk of myocardial inflammation following the administration mRNA-based vaccines. Even though first epidemiological analyses and numerous case reports investigated potential relationships, endomyocardial biopsy (EMB)-proven cases are limited. Here, we present a comprehensive histopathological analysis EMBs from 15 patients with reduced...
We investigated the effect of pharmacological inhibition interleukin converting enzyme (ICE) on cardiac inflammation, apoptosis, fibrosis, and left ventricular function in an animal model diabetes.Diabetes was induced 24 Sprague-Dawley rats by injection streptozotozin (STZ) (70 mg/kg). Diabetic animals were treated with inhibitor (ICEI) (n = 12) or a placebo 12). Nondiabetic served as controls Left documented 6 weeks after induction diabetes. Cardiac tissue analyzed for expression cytokines,...
Abstract Left ventricular (LV) remodeling is known to contribute morbidity and mortality after myocardial infarction (MI). Because LV strongly associated with an inflammatory response, we investigated whether or not TLR-4 influences survival in a mice model of MI. Six days MI induction, TLR4 knockout (KO)-MI showed improved function 32 reduced as indexed by levels atrial natriuretic factor total collagen well heart weight body ratio when compared WT-MI mice. This was reduction protein the...
The mechanisms contributing to diabetic cardiomyopathy, as well the protective pathways of kallikrein-kinin-system (KKS), are incompletely understood. In a kallikrein-overexpressing rat model streptozotocin (STZ)-induced we investigated involvement inflammatory pathways, endothelial dysfunction, and oxidative stress. Six weeks after STZ injection, impairment left ventricular (LV) function parameters measured by Millar-tip catheter (peak LV systolic pressure; dP/dtmax; dP/dtmin) was...
OBJECTIVE Diabetic cardiomyopathy is associated with increased mortality in patients diabetes. The underlying pathology of this disease still under discussion. We studied the role kinin B1 receptor on development experimental diabetic cardiomyopathy. RESEARCH DESIGN AND METHODS utilized knockout mice and investigated cardiac inflammation, fibrosis, oxidative stress after induction streptozotocin (STZ)-induced Furthermore, left ventricular function was measured by pressure-volume loops 8...
The hallmarks of diabetic cardiomyopathy are cardiac oxidative stress, intramyocardial inflammation, fibrosis, and apoptosis. Given the antioxidative, antiinflammatory, antiapoptotic potential high-density lipoprotein (HDL), we evaluated hypothesis that increased HDL via gene transfer (GT) with human apolipoprotein (apo) A-I, principal HDL, may reduce development cardiomyopathy.Intravenous GT 3x10(12) particles/kg E1E3E4-deleted vector Ad.hapoA-I, expressing apoA-I, or Ad.Null, containing no...
Myocarditis is an important cause for cardiac failure, especially in younger patients, followed by the development of dysfunction and death. The present study investigated whether gene deletion matrix metalloproteinase-2 influences inflammation function murine coxsackievirus B3 (CVB3)-induced myocarditis.Matrix knockout mice (MMP-2(-/-)) their wild-type controls (WT) were infected with CVB3 to induce myocarditis. Three days after infection, increased invasion CD4(+)-activated T cells into...
Background Variants of the desmosomal protein desmoplakin are associated with arrhythmogenic cardiomyopathy, an important cause ventricular arrhythmias in children and young adults. Disease penetrance variants is incomplete variant carriers may display noncardiac, dermatologic phenotypes. We describe a novel cardiac phenotype truncating variant, likely causing mechanical instability myocardial desmosomes. Methods Results In 2 brothers recurrent myocarditis triggered by physical exercise,...
Abstract Aims Cardiac involvement in COVID-19 is associated with adverse outcome. However, it unclear whether cell-specific consequences are cardiac SARS-CoV-2 infection. Therefore, we investigated heart tissue utilizing situ hybridization, immunohistochemistry, and RNA-sequencing consecutive autopsy cases to quantify virus load characterize COVID-19. Methods results In this study, 95 SARS-CoV-2-positive were included. A relevant the was detected 41/95 deceased (43%). Massive analysis of...
Cardiac amyloidosis (CA) is an underappreciated cause of morbidity and mortality. Light-chain (AL) transthyretin (ATTR) have different disease trajectories. No data are available on subtype-specific modes death (MOD) in patients with CA.We retrospectively investigated 66 AL 48 wild-type ATTR (ATTRwt) from 2000 to 2018. ATTRwt differed by age (74.6 ± 5.4 years vs. 63 10.8 years), posterior wall thickness (16.8 3.3 mm 14.3 2.2 mm), left ventricular mass index (180.7 63.2 g/m2 133.5 42.2 g/m2),...
Abstract Plasminogen activator inhibitor-1 (PAI-1) has a cardioprotective function in mice by repressing cardiac fibrosis through TGF-β and plasminogen-mediated pathways. In addition it is known to be involved the recruitment polarization of monocytes/macrophages towards M2 phenotype cancer. Here, we investigated expression PAI-1 human dilated cardiomyopathy (DCM) inflammatory (DCMi) its effect on macrophage polarization. We retrospectively analyzed endomyocardial biopsies (EMBs) patients...
Diabetic cardiomyopathy includes fibrosis. Kallikrein (KLK) can inhibit collagen synthesis and promote breakdown. We investigated cardiac fibrosis left ventricular (LV) function in transgenic rats (TGR) expressing the human kallikrein 1 (hKLK1) gene streptozotocin (STZ) -induced diabetic conditions. Six weeks after STZ injection, LV was determined male Sprague-Dawley (SD) TGR(hKLK1) (n=10/group) by a Millar tip catheter. Total content (Sirius Red staining) expression of types I, III, VI were...