A5050653047- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Autopsy Techniques and Outcomes
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Forensic and Genetic Research
- Palliative Care and End-of-Life Issues
- Forensic Fingerprint Detection Methods
- Infection Control and Ventilation
- Restraint-Related Deaths
- COVID-19 epidemiological studies
- Psychopathy, Forensic Psychiatry, Sexual Offending
- SARS-CoV-2 detection and testing
- Spectroscopy Techniques in Biomedical and Chemical Research
- Venous Thromboembolism Diagnosis and Management
- Hepatitis B Virus Studies
- Injury Epidemiology and Prevention
- Alcohol Consumption and Health Effects
- Climate Change and Health Impacts
- Genital Health and Disease
- Liver Disease Diagnosis and Treatment
- COVID-19 diagnosis using AI
- Healthcare cost, quality, practices
- Hepatitis C virus research
- Viral Infections and Immunology Research
Universität Hamburg
2012-2024
University Medical Center Hamburg-Eppendorf
2012-2024
Corvid Technologies (United States)
2022
RWTH Aachen University
2022
Universitätsklinikum Gießen und Marburg
2022
Bundeswehrkrankenhaus
2015-2020
Gesundheitsamt
2017
The new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused more than 210 000 deaths worldwide. However, little is known about the causes of death and virus's pathologic features.To validate compare clinical findings with data from medical autopsy, virtual virologic tests.Prospective cohort study.Autopsies performed at a single academic center, as mandated by German federal state Hamburg for patients dying polymerase chain reaction-confirmed diagnosis...
Prominent clinical symptoms of COVID-19 include CNS manifestations. However, it is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent COVID-19, gains access to and causes neuropathological changes. We investigated brain tissue patients who died from for glial responses, inflammatory changes, presence SARS-CoV-2 in CNS.In this post-mortem case series, we features brains between March 13 April 24, 2020, Hamburg, Germany. Inclusion criteria...
Autopsies of deceased with a confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can provide important insights into the novel disease and its course. Furthermore, autopsies are essential for correct statistical recording 2019 (COVID-19) deaths. In northern German Federal State Hamburg, all deaths Hamburg citizens ante- or postmortem PCR-confirmed SARS-CoV-2 have been autopsied since outbreak pandemic in Germany. Our evaluation provides systematic overview first...
Extrapulmonary manifestations of COVID-19 have gained attention due to their links clinical outcomes and potential long-term sequelae1. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) displays tropism towards several organs, including the heart kidney. Whether it also directly affects liver has been debated2,3. Here we provide clinical, histopathological, molecular bioinformatic evidence for hepatic SARS-CoV-2. We find that injury, indicated by a high frequency abnormal function...
Autopsies are an important tool in medicine, dissecting disease pathophysiology and causes of death. In COVID-19, autopsies revealed e.g., the effects on pulmonary (micro)vasculature or nervous system, systemic viral spread, interplay with immune system. To facilitate multicentre autopsy-based studies provide a central hub supporting autopsy centres, researchers, data analyses reporting, April 2020 German COVID-19 Autopsy Registry (DeRegCOVID) was launched. The electronic registry uses...
Abstract Aims Cardiac involvement in COVID-19 is associated with adverse outcome. However, it unclear whether cell-specific consequences are cardiac SARS-CoV-2 infection. Therefore, we investigated heart tissue utilizing situ hybridization, immunohistochemistry, and RNA-sequencing consecutive autopsy cases to quantify virus load characterize COVID-19. Methods results In this study, 95 SARS-CoV-2-positive were included. A relevant the was detected 41/95 deceased (43%). Massive analysis of...
Forensic medicine and pathology involve specific health risks, whereby workers are dealing with microorganisms, cells or parasites, which referred to as biological agents. Biological agents divided into four categories according § 3 of the Agents Ordinance. The newly identified coronavirus, severe acute respiratory syndrome, coronavirus 2 (SARS-CoV-2) that has spread rapidly around world is placed category Ordinance, meaning pathogens can cause serious illnesses in humans may pose a risk...
Confronted with an emerging infectious disease at the beginning of COVID-19 pandemic, medical community faced concerns regarding safety autopsies on those who died disease. This attitude has changed, and are now recognized as indispensable tools for understanding COVID-19, but true risk infection to autopsy staff is nevertheless still debated. To clarify rate SARS-CoV-2 contamination in personal protective equipment (PPE), swabs were taken nine points PPE one physician assistant after each...
Abstract The body of a deceased with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is considered infectious. In this study, we present the results infectivity testing and mortuary staff for SARS-CoV-2. We performed real-time quantitative polymerase chain reaction (RT-qPCR) SARS-CoV-2 on 33 decedents ante mortem confirmed infection. Swabs surface from five different regions bag or coffin were examined. A subset swabs was brought into cell culture. addition, screening...
In severe cases, SARS-CoV-2 infection leads to acute respiratory distress syndrome (ARDS), often treated by extracorporeal membrane oxygenation (ECMO). During ECMO therapy, anticoagulation is crucial prevent device-associated thrombosis and device failure, however, it associated with bleeding complications. COVID-19, additional pathologies, such as endotheliitis, may further increase the risk of To assess frequency events, we analyzed data from German COVID-19 autopsy registry (DeRegCOVID).
Differentiating homicidal or suicidal deaths in presence of a singular stab wound to the anterior lateral trunk is still challenge forensic practice. There are numerous criteria literature and current textbooks distinguish between self-inflicted injuries homicide. The applicability these single will be examined by elucidating 12 suicides 33 homicides, each with injury were largely confirmed. An instrumentality stuck corpse was always associated suicide given cohort. In summary, final...
The transmission of viral and non-viral infectious pathogens continues to be the most serious potential adverse effects allogenic tissue transplantations. EU Directive 2006/17/EC stipulates that cadaveric blood specimens for serology testing in context post-mortem donation must taken not later than 24 h post-mortem. An expanded time slot would significantly improve availability donations, but there are no significant data on stability assays anti-human immunodeficiency virus (HIV),...
Injury-related asphyxia is one of the most common causes death in children Germany. However, only a few systematic studies have analyzed and circumstances adolescents.All cases adolescents (0-21 years age) among Hamburg Legal Medical Department's autopsy from 1998 to 2017 were retrospectively with special focus on how often external findings completely absent.Among 249 fatal asphyxia, 68% accidents, 14% suicides, 13% homicides. Most involved boys. Adolescents young adults aged 15-21...
Objective: According to EU regulations (EU directive 2006/17/EC), blood specimens for virologic testing in the context of post-mortal tissue donation must be taken not later than 24 h post mortem. Methods: To verify validity NAT collected later, viral nucleic acid concentrations were monitored samples deceased persons infected with HIV (n = 7), HBV 5), and HCV 17) upon admission at 12 h, 36 48 RNA quantified using Cobas TaqMan (Roche), DNA was measured by in-house PCR. Results: A more...